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Details

Stereochemistry ACHIRAL
Molecular Formula C15H23NO3.ClH
Molecular Weight 301.809
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARETHOXYCAINE HYDROCHLORIDE

SMILES

Cl.CCOC1=CC=C(C=C1)C(=O)OCCN(CC)CC

InChI

InChIKey=SFLZPZAKIKUJKP-UHFFFAOYSA-N
InChI=1S/C15H23NO3.ClH/c1-4-16(5-2)11-12-19-15(17)13-7-9-14(10-8-13)18-6-3;/h7-10H,4-6,11-12H2,1-3H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C15H23NO3
Molecular Weight 265.348
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created using several sources including: http://www.ncbi.nlm.nih.gov/pubmed/5755894 https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA215&lpg=PA215&dq=PARETHOXYCAINE+was+developed+by&source=bl&ots=R3QAjHIrB5&sig=Qf1Lc12DBhPI8GED195f8oYqv3A&hl=en&sa=X&ved=0ahUKEwjG9ZnS6q7LAhUEcz4KHaX1DwEQ6AEIHjAB#v=onepage&q=PARETHOXYCAINE%20was%20developed%20by&f=false; http://www.annualreviews.org/doi/abs/10.1146/annurev.pa.09.040169.002443?journalCode=pharmtox.1&; http://journals.lww.com/anesthesia-analgesia/Citation/1952/11000/Intracaine_in_Oil_for_Caudal_Anesthesia_and.20.aspx

Parethoxycaine (Intracaine) is an ester series local anesthetic agent. It has been used by topical application mainly for mouth and throat.

Originator

Squibb
11
Curator's Comment: Squibb Laboratories were producing Introcaine since 1944.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Intracaine

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
5 % 3 times / week multiple, topical
Studied dose
Dose: 5 %, 3 times / week
Route: topical
Route: multiple
Dose: 5 %, 3 times / week
Sources:
https://pubmed.ncbi.nlm.nih.gov/18892064/
healthy, 34 years
Health Status: healthy
Age Group: 34 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/18892064/
Other AEs: Pruritus...
Other AEs:
Pruritus
Sources:
https://pubmed.ncbi.nlm.nih.gov/18892064/
AEs

AEs

AESignificanceDosePopulation
Pruritus
5 % 3 times / week multiple, topical
Studied dose
Dose: 5 %, 3 times / week
Route: topical
Route: multiple
Dose: 5 %, 3 times / week
Sources:
https://pubmed.ncbi.nlm.nih.gov/18892064/
healthy, 34 years
Health Status: healthy
Age Group: 34 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/18892064/
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L1O71
Alfa Chemistry
94-23-5
https://www.alfa-chemistry.com/cas_94-23-5.htm
Ambinter
Amb1817122
http://www.ambinter.com/reference/1817122
AsisChem
G00475
Aurora Fine Chemicals LLC
A12.865.000
http://online.aurorafinechemicals.com/info?ID=A12.865.000
Aurora Fine Chemicals LLC
K02.232.516
http://online.aurorafinechemicals.com/info?ID=K02.232.516
BOC Sciences
136-46-9
ChemBridge
6771521
Chemieliva Pharmaceutical Co., Ltd
PBCM1008192
Chemspace
CSSS00025767298
https://chem-space.com/CSSS00025767298
ChemTik
CTK5H6001
eMolecules
2415457
eMolecules
300058689
eMolecules
4471674
Enamine
Z252849086
IBScreen
STOCK2S-96942
Lab Network
LN00541670
Lab Network
LN01214070
mcule
MCULE-8009544048
https://mcule.com/MCULE-8009544048/
MolPort
MolPort-000-743-709
MolPort
MolPort-002-221-761
MuseChem
M070671
MuseChem
M214997
NovoSeek
7183
Parchem
102183
https://www.parchem.com/chemical-supplier-distributor/2-Diethylaminoethyl-4-Ethoxybenzoate-102183.aspx
Pharmeks
PHAR058781
Princeton BioMolecular Research
OSSK_579829
Scientific Exchange
F-033683
Sigma Aldrich
PH014090
Sigma Aldrich
PH014090|ALDRICH
Smolecule
S584930
https://www.smolecule.com/products/s584930
Specs
AO-365/40892107
Vitas-M Laboratory
STK095500
ZINC
ZINC000001833029
http://zinc15.docking.org/substances/ZINC000001833029
PubMed

PubMed

TitleDatePubMed
[Relation between the physical-chemical properties, chemical reactivity and local anesthetic effect in the parethoxycaine series. 22].
1968-05
Patents

Patents

US2431553
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 5 % intracaine in oil.
5% rectal intracaine-oil mixture for caudal anesthesia and analgesia in rectal surgery
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:23:01 GMT 2025
Edited
by admin
on Mon Mar 31 18:23:01 GMT 2025
Record UNII
414P5USJ7F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARETHOXYCAINE HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
PARETHOXYCAINE HYDROCHLORIDE [MI]
Preferred Name English
PARETHOXYCAINE HCL
Common Name English
Parethoxycaine hydrochloride [WHO-DD]
Common Name English
PARETHOXYCAINE HYDROCHLORIDE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C245
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
Code System Code Type Description
SMS_ID
100000079748
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
EPA CompTox
DTXSID80159621
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
NCI_THESAURUS
C81398
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
PUBCHEM
8694
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
FDA UNII
414P5USJ7F
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
ChEMBL
CHEMBL421669
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
EVMPD
SUB14777MIG
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
ECHA (EC/EINECS)
205-246-4
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
MERCK INDEX
m866
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY Merck Index
RXCUI
236250
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY RxNorm
CAS
136-46-9
Created by admin on Mon Mar 31 18:23:01 GMT 2025 , Edited by admin on Mon Mar 31 18:23:01 GMT 2025
PRIMARY
Related Record Type Details
Structure of PARETHOXYCAINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of PARETHOXYCAINE
ACTIVE MOIETY
NIH
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