Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H23NO3.ClH |
Molecular Weight | 301.809 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCOC1=CC=C(C=C1)C(=O)OCCN(CC)CC
InChI
InChIKey=SFLZPZAKIKUJKP-UHFFFAOYSA-N
InChI=1S/C15H23NO3.ClH/c1-4-16(5-2)11-12-19-15(17)13-7-9-14(10-8-13)18-6-3;/h7-10H,4-6,11-12H2,1-3H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C15H23NO3 |
Molecular Weight | 265.348 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/6681975Curator's Comment: Description was created using several sources including:
http://www.ncbi.nlm.nih.gov/pubmed/5755894
https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA215&lpg=PA215&dq=PARETHOXYCAINE+was+developed+by&source=bl&ots=R3QAjHIrB5&sig=Qf1Lc12DBhPI8GED195f8oYqv3A&hl=en&sa=X&ved=0ahUKEwjG9ZnS6q7LAhUEcz4KHaX1DwEQ6AEIHjAB#v=onepage&q=PARETHOXYCAINE%20was%20developed%20by&f=false;
http://www.annualreviews.org/doi/abs/10.1146/annurev.pa.09.040169.002443?journalCode=pharmtox.1&;
http://journals.lww.com/anesthesia-analgesia/Citation/1952/11000/Intracaine_in_Oil_for_Caudal_Anesthesia_and.20.aspx
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6681975
Curator's Comment: Description was created using several sources including:
http://www.ncbi.nlm.nih.gov/pubmed/5755894
https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA215&lpg=PA215&dq=PARETHOXYCAINE+was+developed+by&source=bl&ots=R3QAjHIrB5&sig=Qf1Lc12DBhPI8GED195f8oYqv3A&hl=en&sa=X&ved=0ahUKEwjG9ZnS6q7LAhUEcz4KHaX1DwEQ6AEIHjAB#v=onepage&q=PARETHOXYCAINE%20was%20developed%20by&f=false;
http://www.annualreviews.org/doi/abs/10.1146/annurev.pa.09.040169.002443?journalCode=pharmtox.1&;
http://journals.lww.com/anesthesia-analgesia/Citation/1952/11000/Intracaine_in_Oil_for_Caudal_Anesthesia_and.20.aspx
Parethoxycaine (Intracaine) is an ester series local anesthetic agent. It has been used by topical application mainly for mouth and throat.
Originator
Sources: http://www.ncbi.nlm.nih.gov/pubmed/20285898
Curator's Comment: Squibb Laboratories were producing Introcaine since 1944.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sources: http://www.google.com.tj/patents/US2431553 |
Primary | Intracaine Approved UseUnknown |
Doses
Dose | Population | Adverse events |
---|---|---|
5 % 3 times / week multiple, topical Studied dose Dose: 5 %, 3 times / week Route: topical Route: multiple Dose: 5 %, 3 times / week Sources: |
healthy, 34 years n = 1 Health Status: healthy Age Group: 34 years Sex: M Population Size: 1 Sources: |
Other AEs: Pruritus... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Pruritus | 5 % 3 times / week multiple, topical Studied dose Dose: 5 %, 3 times / week Route: topical Route: multiple Dose: 5 %, 3 times / week Sources: |
healthy, 34 years n = 1 Health Status: healthy Age Group: 34 years Sex: M Population Size: 1 Sources: |
Sample Use Guides
In Vivo Use Guide
Sources: http://journals.lww.com/anesthesia-analgesia/Citation/1952/11000/Intracaine_in_Oil_for_Caudal_Anesthesia_and.20.aspx
Curator's Comment: 5 % intracaine in oil.
5% rectal intracaine-oil mixture for caudal anesthesia and analgesia in rectal surgery
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:14:55 GMT 2023
by
admin
on
Fri Dec 15 16:14:55 GMT 2023
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Record UNII |
414P5USJ7F
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C245
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100000079748
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DTXSID80159621
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C81398
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8694
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414P5USJ7F
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CHEMBL421669
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SUB14777MIG
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205-246-4
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m866
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236250
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136-46-9
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |