Rhodamine B is a fluorescent dye whose quantum yield is strongly dependent on temperature in the range of 0°C to 100°C, making it ideal for liquid based systems. It is a cell-permeant fluorogenic dye most often used as a conjugate to antibodies and proteins for fluorescence detection in microscopy. Rhodamine B is widely used in industrial purposes, such as printing and dyeing in textile, paper, paints, leathers etc. Rhodamine B was tested for use as a biomarker in oral rabies vaccines for raccoons, to identify animals that have eaten a vaccine bait. It has also been used as an anterograde and retrograde tracer in neurons and in nanoparticles to detect apoptosis.