Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H10N4S |
Molecular Weight | 170.235 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=N)SCCC1=CN=CN1
InChI
InChIKey=PEHSVUKQDJULKE-UHFFFAOYSA-N
InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
Approval Year
PubMed
Title | Date | PubMed |
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Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. | 1997 Feb |
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Genomic organization and characterization of splice variants of the human histamine H3 receptor. | 2001 Apr 15 |
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Histaminergic modulation of GABAergic transmission in rat ventromedial hypothalamic neurones. | 2001 Aug 1 |
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Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. | 2001 Dec |
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Cloning and characterization of a novel human histamine receptor. | 2001 Mar |
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Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. | 2001 Mar |
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Pharmacological analysis of immepip and imetit homologues. Further evidence for histamine H(3) receptor heterogeneity? | 2001 Oct 15 |
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Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors. | 2002 Jan |
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Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway. | 2002 Jan |
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Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. | 2002 Jun |
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Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor. | 2002 Jun |
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The role of transmembrane helix 5 in agonist binding to the human H3 receptor. | 2002 May |
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Characteristics of recombinantly expressed rat and human histamine H3 receptors. | 2002 Oct 18 |
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Histaminergic modulation of the intact respiratory network of adult mice. | 2003 Feb |
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Generation and characterization of highly constitutive active histamine H3 receptors. | 2003 Oct |
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Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. | 2004 May |
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Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. | 2004 Sep |
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H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways. | 2005 Jan |
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G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. | 2005 Jul |
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Regulation of norepinephrine release from isolated bovine irides by histamine. | 2006 Jul |
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Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. | 2007 Apr 15 |
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Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. | 2008 Aug |
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Cloning and characterization of the monkey histamine H3 receptor isoforms. | 2008 Dec 28 |
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Histamine depolarizes neurons in the dorsal vagal complex. | 2008 Feb 13 |
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Distinctive role of central histamine H3 receptor in various orexigenic pathways. | 2008 Jan 28 |
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Participation of histamine H3 receptors in experimental allergic rhinitis of mice. | 2008 Oct |
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Effects of histamine H(3) receptor activation on the behavioral-stimulant effects of methamphetamine and cocaine in mice and squirrel monkeys. | 2009 |
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The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster. | 2009 Mar |
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Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. | 2010 Nov 1 |
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Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | 2011 Dec 8 |
Patents
Sample Use Guides
mice: 10 mg/kg i.p.
rats: 5 or 10 mg/kg i.p.
rsts: 10 umol/kg i.a
rats: 10 nmol/side (injection into basolateral amygdala)
rats: 10 ug/side (injection into hippocampus)
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15131002
Imetit (EC50 25 nm) could mimic histamine effect in inducing eosinophil shape change.
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677MJ4VPZC
Created by
admin on Fri Dec 15 18:20:31 GMT 2023 , Edited by admin on Fri Dec 15 18:20:31 GMT 2023
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IMETIT
Created by
admin on Fri Dec 15 18:20:31 GMT 2023 , Edited by admin on Fri Dec 15 18:20:31 GMT 2023
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3692
Created by
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102203-18-9
Created by
admin on Fri Dec 15 18:20:31 GMT 2023 , Edited by admin on Fri Dec 15 18:20:31 GMT 2023
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DTXSID8043737
Created by
admin on Fri Dec 15 18:20:31 GMT 2023 , Edited by admin on Fri Dec 15 18:20:31 GMT 2023
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PRIMARY |
SUBSTANCE RECORD