Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H10N4S.2ClH |
| Molecular Weight | 243.157 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC(=N)SCCC1=CN=CN1
InChI
InChIKey=YWGSVJQHOIKXEG-UHFFFAOYSA-N
InChI=1S/C6H10N4S.2ClH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H10N4S |
| Molecular Weight | 170.235 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | 2011-12-08 |
|
| Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. | 2011-06 |
|
| Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. | 2010-11-01 |
|
| [Substance P and its receptors are involved in the effect of histamine H3 receptor agonist, IMETIT on nasal allergic symptoms in guinea pigs]. | 2010-06 |
|
| [Effect of H3R agonist, IMETIT on allergic rhinitis in guinea pigs]. | 2010-06 |
|
| Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release. | 2009-12-15 |
|
| Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. | 2009-11-12 |
|
| The ameliorating effects of NMDA receptor agonists on histamine H1 antagonist-induced memory and hippocampal theta disruptions are prevented by the H3 receptor agonist in rats. | 2009-08-14 |
|
| Urethane, but not pentobarbitone, attenuates presynaptic receptor function in rats: a contribution to the choice of anaesthetic. | 2009-08 |
|
| JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. | 2009-06 |
|
| The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster. | 2009-03 |
|
| Effects of histamine H(3) receptor activation on the behavioral-stimulant effects of methamphetamine and cocaine in mice and squirrel monkeys. | 2009 |
|
| Cloning and characterization of the monkey histamine H3 receptor isoforms. | 2008-12-28 |
|
| Participation of histamine H3 receptors in experimental allergic rhinitis of mice. | 2008-10 |
|
| Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. | 2008-08 |
|
| Autoregulation of McA-RH7777 hepatoma cell proliferation by histamine H3 receptors. | 2008-08 |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008-06-06 |
|
| Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa derived extracellular dopamine in dopamine-denervated rat striatum. | 2008-06-05 |
|
| Histamine depolarizes neurons in the dorsal vagal complex. | 2008-02-13 |
|
| Distinctive role of central histamine H3 receptor in various orexigenic pathways. | 2008-01-28 |
|
| Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. | 2007-04-15 |
|
| Modification of formalin-induced nociception by different histamine receptor agonists and antagonists. | 2007-01-15 |
|
| Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate dopamine levels. | 2006-12-15 |
|
| Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP. | 2006-10-10 |
|
| Homologous down-regulation of histamine H3 receptors in rat striatal slices. | 2006-08 |
|
| Regulation of norepinephrine release from isolated bovine irides by histamine. | 2006-07 |
|
| Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease. | 2006-06 |
|
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | 2006-04 |
|
| G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. | 2005-07 |
|
| Significance of Conversation between Mast Cells and Nerves. | 2005-06-15 |
|
| H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways. | 2005-01 |
|
| Histamine H3 receptors modulate reactive hyperemia in rat gut. | 2004-09 |
|
| Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. | 2004-09 |
|
| Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. | 2004-05 |
|
| Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. | 2004-05 |
|
| Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat. | 2004-03 |
|
| Role of histamine receptors in the regulation of edema and circulation postburn. | 2003-12 |
|
| Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. | 2003-11 |
|
| Generation and characterization of highly constitutive active histamine H3 receptors. | 2003-10 |
|
| Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats. | 2003-09-15 |
|
| An in vitro study of histamine on the pulmonary artery of the Wistar-Kyoto and spontaneously hypertensive rats. | 2003-05-30 |
|
| Molecular and pharmacological characterization of the mouse histamine H3 receptor. | 2003-04-25 |
|
| Histaminergic modulation of the intact respiratory network of adult mice. | 2003-02 |
|
| Characteristics of recombinantly expressed rat and human histamine H3 receptors. | 2002-10-18 |
|
| Functional analysis of histamine receptor subtypes involved in endothelium-mediated relaxation of the human uterine artery. | 2002-08 |
|
| Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. | 2002-06 |
|
| Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor. | 2002-06 |
|
| The role of transmembrane helix 5 in agonist binding to the human H3 receptor. | 2002-05 |
|
| Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors. | 2002-01 |
|
| Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. | 1997-02 |
Patents
Sample Use Guides
mice: 10 mg/kg i.p.
rats: 5 or 10 mg/kg i.p.
rsts: 10 umol/kg i.a
rats: 10 nmol/side (injection into basolateral amygdala)
rats: 10 ug/side (injection into hippocampus)
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 19:21:05 GMT 2025
by
admin
on
Wed Apr 02 19:21:05 GMT 2025
|
| Record UNII |
BLP29DZ4YA
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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32471-18-4
Created by
admin on Wed Apr 02 19:21:05 GMT 2025 , Edited by admin on Wed Apr 02 19:21:05 GMT 2025
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PRIMARY | |||
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BLP29DZ4YA
Created by
admin on Wed Apr 02 19:21:05 GMT 2025 , Edited by admin on Wed Apr 02 19:21:05 GMT 2025
|
PRIMARY |
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PARENT -> SALT/SOLVATE |
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