TERLAKIREN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H48N4O7S
Molecular Weight	620.8
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)N2CCOCC2)C(=O)N[C@@H](CC3CCCCC3)[C@@H](O)C(=O)OC(C)C

InChI

InChIKey=UZQBKCWYZBHBOW-YIPNQBBMSA-N

InChI=1S/C31H48N4O7S/c1-21(2)42-30(39)27(36)24(18-22-10-6-4-7-11-22)32-29(38)26(20-43-3)33-28(37)25(19-23-12-8-5-9-13-23)34-31(40)35-14-16-41-17-15-35/h5,8-9,12-13,21-22,24-27,36H,4,6-7,10-11,14-20H2,1-3H3,(H,32,38)(H,33,37)(H,34,40)/t24-,25-,26-,27+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9323544 | https://www.ncbi.nlm.nih.gov/pubmed/9231029 | https://www.ncbi.nlm.nih.gov/pubmed/1383634

Terlakiren (also known as CP80794) is a cysteinamide derivative patented by Pfizer Inc. as potent renin inhibitor. Terlakirens inhibitory potency against plasma renin of guinea pigs, dogs, and monkeys ranges from 0.3 to 0.7 nM. In preclinical models, Terlakiren caused significantly greater increases in renal blood flow and suppressed renin activity to a greater degree than captopril.

Originator

Approval Year

PubMed

Title	Date	PubMed
Quantitation of 4-cyclohexyl-2-hydroxy-3-(3-methylsulfanyl-2- [2-[(morpholine-4-carbonyl)amino]-3-phenylpropionylamino]propi onylamino ) butyric acid isopropyl ester (CP-80,794), a renin inhibitor, and its hydrolytic cleavage metabolite 2-[(morpholine-4-carbonyl)amino]-3-phenylpropionic acid (CP-84,364) in dog and human plasma by high-performance liquid chromatography.	1997 Aug 29	9323544

Patents

Name

Type

Language

TERLAKIREN

Official Name

English

CP-80,794

Code

English

terlakiren [INN]

Common Name

English

TERLAKIREN [USAN]

Common Name

English

CP-80794

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C270