Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C16H19N3O5 |
Molecular Weight | 333.3392 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H](CCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O)C(O)=O
InChI
InChIKey=CATMPQFFVNKDEY-YPMHNXCESA-N
InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13+/m1/s1
Golotimod (SCV-07) is compound that has been investigated as a medicine for the treatment of tuberculosis, and various other viral and bacterial infections. Golotimod acts broadly on the Toll-like receptor (TLR) pathway. It stimulates the T-helper 1 (Th1) type immune response and blocks signal transducers and activator of transcription 3 (STAT3) mediated signaling. Treatment of tuberculosis with golotimod improves clearance of mycobacteria, cavity healing, and immune parameters and also reduced symptoms (such as fever, weakness, sweating, dry cough, productive cough, dyspnea, chest pain, tachycardia) without adverse effects. Phase II clinical trials have been completed to assess its safety and tolerability.
Approval Year
PubMed
Title | Date | PubMed |
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Immune system stimulator shows promise against tuberculosis. | 2002 Dec |
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Gateways to clinical trials. | 2003 Jun |
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Development of an efficient enzymatic production of gamma-D-glutamyl-L-tryptophan (SCV-07), a prospective medicine for tuberculosis, with bacterial gamma-glutamyltranspeptidase. | 2004 Aug 5 |
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SCV-07 (SciClone Pharmaceuticals/Verta). | 2006 Feb |
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Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). | 2010 Oct |
Patents
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C129820
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300000034186
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2367440
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637C487Y09
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C470075
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6992140
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DB05475
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C76497
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CHEMBL2103812
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229305-39-9
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SS-36
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DTXSID10177474
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ACTIVE MOIETY