Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H20O12 |
Molecular Weight | 464.3763 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1O[C@@H](OC2=C(OC3=C(C(O)=CC(O)=C3)C2=O)C4=CC(O)=C(O)C(O)=C4)[C@H](O)[C@H](O)[C@H]1O
InChI
InChIKey=DCYOADKBABEMIQ-OWMUPTOHSA-N
InChI=1S/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-27,29-30H,1H3/t6-,14-,17+,18+,21-/m0/s1
Myricitrin is a naturally occurring polyphenol hydroxy flavonoid. Myricitrin has a variety of beneficial properties, such as antiviral, antimicrobial, antinociceptive, and anticarcinogenic activities. In particular, myricitrin possesses stronger oxidative resistance and free radical scavenging activity than other flavonol rhamnosides or quercetin. Myricitrin showed antipsychotic-like effects in animal models at doses that did not induce catalepsy or alter locomotor activity, suggesting that myricitrin may be a potential drug treatment for the positive symptoms of schizophrenia.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2023 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24716406 |
0.5 µM [Ki] | ||
Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12972054 |
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Target ID: CHEMBL2567 |
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Target ID: CHEMBL4366 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Inhibitory activity of flavonoids and tannins against HIV-1 protease. | 2000 Sep |
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Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. | 2007 Mar |
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[A new flavonol glycoside from Baeckea Frutescens L]. | 2008 Oct |
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Isolated flavonoids against mammary tumour cells LM2. | 2009 Jan-Feb |
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Gmelinoside I, a new flavonol glycoside from Limonium gmelinii. | 2010 Jul |
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Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. | 2014 Nov 1 |
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Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. | 2015 Mar 25 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21689712
Mice: 5, 10, and 30 mg/kg
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28751937
RAW264.7 cells were pretreated with 400 ug/ml myricitrin for 2 h or not and then were incubated with LPS (100 ng/ml) for 15 min. Noncytotoxic level of myricitrin inhibited p47phox which was transferred to the membrane and suppressed the interaction between p47phox and gp91phox.
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17912-87-7
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DTXSID40170771
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5281673
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70082
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2180
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MYRICITRIN
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241-856-7
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19803
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C008577
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SUBSTANCE RECORD