Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H22N7O10.Na |
| Molecular Weight | 519.3979 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC1=NC=C(N1CCOC(=O)CN(CC([O-])=O)CC(=O)OCCN2C(C)=NC=C2[N+]([O-])=O)[N+]([O-])=O
InChI
InChIKey=FWYUJENICVGSJH-UHFFFAOYSA-M
InChI=1S/C18H23N7O10.Na/c1-12-19-7-14(24(30)31)22(12)3-5-34-17(28)10-21(9-16(26)27)11-18(29)35-6-4-23-13(2)20-8-15(23)25(32)33;/h7-8H,3-6,9-11H2,1-2H3,(H,26,27);/q;+1/p-1
Sodium glycididazole (CMNA), a nitroimidazole compound that has a radiation-enhancing effect. This drug was studied in the treatment of patients with various tumors, such as non-small-cell lung cancer, esophageal carcinoma. CMNA combined with chemoradiotherapy participated in phase II clinical trials in patients with locally recurrent squamous cell esophageal carcinoma. It was shown, that CMNA improved curative effects without increasing adverse reactions, and significantly increase survival rates of the patients. The precise mechanism of action CMNA is not clear but is known that it acts through downregulation of ATM signaling pathway.
Approval Year
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NCI_THESAURUS |
C798
Created by
admin on Mon Mar 31 22:37:33 GMT 2025 , Edited by admin on Mon Mar 31 22:37:33 GMT 2025
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300000037464
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298688-44-5
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9914614
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173357-17-0
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DTXSID60432742
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admin on Mon Mar 31 22:37:33 GMT 2025 , Edited by admin on Mon Mar 31 22:37:33 GMT 2025
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5YV419FIJS
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admin on Mon Mar 31 22:37:33 GMT 2025 , Edited by admin on Mon Mar 31 22:37:33 GMT 2025
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C77889
Created by
admin on Mon Mar 31 22:37:33 GMT 2025 , Edited by admin on Mon Mar 31 22:37:33 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
