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Details

Stereochemistry ACHIRAL
Molecular Formula C18H22N7O10.Na
Molecular Weight 519.3979
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM GLYCIDIDAZOLE

SMILES

[Na+].CC1=NC=C(N1CCOC(=O)CN(CC([O-])=O)CC(=O)OCCN2C(C)=NC=C2[N+]([O-])=O)[N+]([O-])=O

InChI

InChIKey=FWYUJENICVGSJH-UHFFFAOYSA-M
InChI=1S/C18H23N7O10.Na/c1-12-19-7-14(24(30)31)22(12)3-5-34-17(28)10-21(9-16(26)27)11-18(29)35-6-4-23-13(2)20-8-15(23)25(32)33;/h7-8H,3-6,9-11H2,1-2H3,(H,26,27);/q;+1/p-1

HIDE SMILES / InChI
Sodium glycididazole (CMNA), a nitroimidazole compound that has a radiation-enhancing effect. This drug was studied in the treatment of patients with various tumors, such as non-small-cell lung cancer, esophageal carcinoma. CMNA combined with chemoradiotherapy participated in phase II clinical trials in patients with locally recurrent squamous cell esophageal carcinoma. It was shown, that CMNA improved curative effects without increasing adverse reactions, and significantly increase survival rates of the patients. The precise mechanism of action CMNA is not clear but is known that it acts through downregulation of ATM signaling pathway.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency

Sample Use Guides

Sodium Glycididazole (CMNa) 800mg/m2.Three times a week (once every other one day),before radiation therapy, total 5-6 weeks.
Route of Administration: Intravenous
Name Type Language
SODIUM GLYCIDIDAZOLE
WHO-DD  
Common Name English
GLYCINE, N,N-BIS(2-(2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHOXY)-2-OXOETHYL)-, SODIUM SALT
Systematic Name English
Sodium glycididazole [WHO-DD]
Common Name English
SGDD
Common Name English
GLYCINE, N,N-BIS(2-(2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHOXY)-2-OXOETHYL)-, SODIUM SALT (1:1)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C798
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
Code System Code Type Description
SMS_ID
300000037464
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY
CAS
298688-44-5
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
SUPERSEDED
PUBCHEM
9914614
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY
CAS
173357-17-0
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID60432742
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY
FDA UNII
5YV419FIJS
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY
NCI_THESAURUS
C77889
Created by admin on Sat Dec 16 09:21:55 GMT 2023 , Edited by admin on Sat Dec 16 09:21:55 GMT 2023
PRIMARY