SODIUM GLYCIDIDAZOLE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H22N7O10.Na
Molecular Weight	519.3979
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CC1=NC=C(N1CCOC(=O)CN(CC([O-])=O)CC(=O)OCCN2C(C)=NC=C2[N+]([O-])=O)[N+]([O-])=O

InChI

InChIKey=FWYUJENICVGSJH-UHFFFAOYSA-M

InChI=1S/C18H23N7O10.Na/c1-12-19-7-14(24(30)31)22(12)3-5-34-17(28)10-21(9-16(26)27)11-18(29)35-6-4-23-13(2)20-8-15(23)25(32)33;/h7-8H,3-6,9-11H2,1-2H3,(H,26,27);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C18H22N7O10
Molecular Weight	496.4082
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26550375 | https://www.ncbi.nlm.nih.gov/pubmed/26586399

Sodium glycididazole (CMNA), a nitroimidazole compound that has a radiation-enhancing effect. This drug was studied in the treatment of patients with various tumors, such as non-small-cell lung cancer, esophageal carcinoma. CMNA combined with chemoradiotherapy participated in phase II clinical trials in patients with locally recurrent squamous cell esophageal carcinoma. It was shown, that CMNA improved curative effects without increasing adverse reactions, and significantly increase survival rates of the patients. The precise mechanism of action CMNA is not clear but is known that it acts through downregulation of ATM signaling pathway.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATM Signaling Pathway 2 Target ID: WP2516 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26586399	Inhibitor 8297

Sample Use Guides

In Vivo Use Guide

Sodium Glycididazole (CMNa) 800mg/m2.Three times a week (once every other one day),before radiation therapy, total 5-6 weeks.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:21:55 GMT 2023` Edited by `admin` on `Sat Dec 16 09:21:55 GMT 2023`
Record UNII	5YV419FIJS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SODIUM GLYCIDIDAZOLE

Common Name

English

GLYCINE, N,N-BIS(2-(2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHOXY)-2-OXOETHYL)-, SODIUM SALT

Systematic Name

English

Sodium glycididazole [WHO-DD]

Common Name

English

SGDD

Common Name

English

GLYCINE, N,N-BIS(2-(2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHOXY)-2-OXOETHYL)-, SODIUM SALT (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C798