Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H22NOS2.Br.H2O |
| Molecular Weight | 418.412 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[Br-].COC1CC(C[N+](C)(C)C1)=C(C2=CC=CS2)C3=CC=CS3
InChI
InChIKey=LESIBJVNNLJUOA-UHFFFAOYSA-M
InChI=1S/C17H22NOS2.BrH.H2O/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;;/h4-9,14H,10-12H2,1-3H3;1H;1H2/q+1;;/p-1
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL216 |
34.0 nM [Ki] | ||
Target ID: CHEMBL211 |
7.7 nM [Ki] | ||
Target ID: CHEMBL245 |
31.0 nM [Ki] | ||
Target ID: CHEMBL1821 |
18.0 nM [Ki] | ||
Target ID: CHEMBL2035 |
11.0 nM [Ki] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Sesden Approved UseVisceral spasms |
Doses
| Dose | Population | Adverse events |
|---|---|---|
15 mg single, intravenous Highest studied dose Dose: 15 mg Route: intravenous Route: single Dose: 15 mg Sources: |
unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: |
|
30 mg 3 times / day multiple, oral Recommended Dose: 30 mg, 3 times / day Route: oral Route: multiple Dose: 30 mg, 3 times / day Sources: |
unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: |
Disc. AE: Eosinophilic pustular folliculitis... AEs leading to discontinuation/dose reduction: Eosinophilic pustular folliculitis Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Eosinophilic pustular folliculitis | Disc. AE | 30 mg 3 times / day multiple, oral Recommended Dose: 30 mg, 3 times / day Route: oral Route: multiple Dose: 30 mg, 3 times / day Sources: |
unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010-12 |
|
| Multiple granulomatous inflammation in the minor salivary glands: a proposed new entity, allergic granulomatous sialadenitis. | 2004-11 |
|
| Eosinophilic pustular folliculitis induced by allopurinol and timepidium bromide. | 2002 |
Patents
Sample Use Guides
Timepidium inhibited dose-dependently
the contraction of isolated guinea pig gallbladder evoked by stimulation at 5 Hz. The mean dose producing a 50 % decrease
in the electrically induced contraction (ID50 value) was 2.4 x 10(-8) g/ml. Timepidium (10(-6) g/ml)
also inhibited, for the most part, the contraction induced by stimulation at 30 Hz.
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| Code System | Code | Type | Description | ||
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11954250
Created by
admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
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PRIMARY | |||
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5X58HSG8LX
Created by
admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
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116383-38-1
Created by
admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
