U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H15O2.Na
Molecular Weight 166.1933
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VALPROATE SODIUM

SMILES

[Na+].CCCC(CCC)C([O-])=O

InChI

InChIKey=AEQFSUDEHCCHBT-UHFFFAOYSA-M
InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://psychopharmacologyinstitute.com/mood-stabilizers/valproate-in-psychiatry-approved-indications-and-off-label-uses/ | https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022152s002lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/12847559 | https://www.ncbi.nlm.nih.gov/pubmed/11742974 | https://www.ncbi.nlm.nih.gov/pubmed/11473107

Valproic acid (VPA; valproate; di-n-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton. FDA approved valproic acid for the treatment of manic episodes associated with bipolar disorder, for the monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures and adjunctive therapy in patients with multiple seizure types that include absence seizures and for the prophylaxis of migraine headaches. The mechanisms of VPA which seem to be of clinical importance in the treatment of epilepsy include increased gamma-aminobutyric acid (GABA)-ergic activity, reduction in excitatory neurotransmission, and modification of monoamines. Recently, it was discovered that the VPA is a class I selective histone deacetylase inhibitor. This activity can be distinguished from its therapeutically exploited antiepileptic activity.

Originator

Sources: Burton B.S. (1882) On the propyl derivatives and decomposition products of ethylacetoacetate. Am Chem J3: 385–395
Curator's Comment: reference retrieved from https://link.springer.com/chapter/10.1007%2F978-3-0348-8759-5_1

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DEPAKENE

Approved Use

Depakene (valproic acid) is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. Depakene (valproic acid) is indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types which include absence seizures. Simple absence is defined as very brief clouding of the sensorium or loss of consciousness accompanied by certain generalized epileptic discharges without other detectable clinical signs. Complex absence is the term used when other signs are also present.
Preventing
STAVZOR

Approved Use

Stavzor (valproic acid) delayed release capsules is indicated for: • Acute treatment of manic episodes associated with bipolar disorder • Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures • Prophylaxis of migraine headaches

Launch Date

2008
Primary
STAVZOR

Approved Use

Stavzor (valproic acid) delayed release capsules is indicated for: • Acute treatment of manic episodes associated with bipolar disorder • Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures • Prophylaxis of migraine headaches

Launch Date

2008
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
107.2 mg/L
500 mg 2 times / day multiple, oral
dose: 500 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
VALPROIC ACID plasma
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: FEMALE / MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1951 mg × h/L
500 mg 2 times / day multiple, oral
dose: 500 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
VALPROIC ACID plasma
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: FEMALE / MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
16 h
1000 mg 1 times / day steady-state, oral
dose: 1000 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
VALPROIC ACID unknown
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
150 mg/kg single, intravenous
Highest studied dose
Dose: 150 mg/kg
Route: intravenous
Route: single
Dose: 150 mg/kg
Sources: Page: p.6
healthy, 30.2 ± 11.7
n = 3
Health Status: healthy
Age Group: 30.2 ± 11.7
Sex: M+F
Population Size: 3
Sources: Page: p.6
DLT: Headache, Nausea...
Dose limiting toxicities:
Headache
Nausea
Sources: Page: p.6
140 mg/kg single, intravenous
MTD
Dose: 140 mg/kg
Route: intravenous
Route: single
Dose: 140 mg/kg
Sources: Page: p.6
healthy, 30.2 ± 11.7
n = 6
Health Status: healthy
Age Group: 30.2 ± 11.7
Sex: M+F
Population Size: 6
Sources: Page: p.6
25 g single, oral
Overdose
Dose: 25 g
Route: oral
Route: single
Dose: 25 g
Sources: Page: p.1
unhealthy, 37
n = 1
Health Status: unhealthy
Condition: Seizures |Bipolar disorder
Age Group: 37
Sex: M
Population Size: 1
Sources: Page: p.1
Disc. AE: Somnolence...
AEs leading to
discontinuation/dose reduction:
Somnolence
Sources: Page: p.1
100 g single, oral
Overdose
Dose: 100 g
Route: oral
Route: single
Dose: 100 g
Sources: Page: 110000
unhealthy, 41
n = 1
Health Status: unhealthy
Condition: Epilepsy
Age Group: 41
Sex: M
Population Size: 1
Sources: Page: 110000
Disc. AE: Coma...
AEs leading to
discontinuation/dose reduction:
Coma
Sources: Page: 110000
120 mg/kg 1 times / day multiple, intravenous
Highest studied dose
Dose: 120 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 120 mg/kg, 1 times / day
Sources: Page: p.179
unhealthy, 62.5
n = 5
Health Status: unhealthy
Condition: Cancer
Age Group: 62.5
Sex: M+F
Population Size: 5
Sources: Page: p.179
DLT: Somnolence...
Dose limiting toxicities:
Somnolence (40%)
Sources: Page: p.179
60 mg/kg 1 times / day multiple, intravenous
MTD
Dose: 60 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 60 mg/kg, 1 times / day
Sources: Page: p.178
unhealthy, 62.5
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 62.5
Sex: M+F
Population Size: 3
Sources: Page: p.178
60 mg/kg 1 times / day multiple, oral
Recommended
Dose: 60 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 60 mg/kg, 1 times / day
Sources: Page: p.1
unhealthy
Health Status: unhealthy
Condition: Seizures
Sources: Page: p.1
Disc. AE: Hepatotoxicity, Pancreatitis...
AEs leading to
discontinuation/dose reduction:
Hepatotoxicity
Pancreatitis
Sources: Page: p.1
AEs

AEs

AESignificanceDosePopulation
Headache DLT
150 mg/kg single, intravenous
Highest studied dose
Dose: 150 mg/kg
Route: intravenous
Route: single
Dose: 150 mg/kg
Sources: Page: p.6
healthy, 30.2 ± 11.7
n = 3
Health Status: healthy
Age Group: 30.2 ± 11.7
Sex: M+F
Population Size: 3
Sources: Page: p.6
Nausea DLT
150 mg/kg single, intravenous
Highest studied dose
Dose: 150 mg/kg
Route: intravenous
Route: single
Dose: 150 mg/kg
Sources: Page: p.6
healthy, 30.2 ± 11.7
n = 3
Health Status: healthy
Age Group: 30.2 ± 11.7
Sex: M+F
Population Size: 3
Sources: Page: p.6
Somnolence Disc. AE
25 g single, oral
Overdose
Dose: 25 g
Route: oral
Route: single
Dose: 25 g
Sources: Page: p.1
unhealthy, 37
n = 1
Health Status: unhealthy
Condition: Seizures |Bipolar disorder
Age Group: 37
Sex: M
Population Size: 1
Sources: Page: p.1
Coma Disc. AE
100 g single, oral
Overdose
Dose: 100 g
Route: oral
Route: single
Dose: 100 g
Sources: Page: 110000
unhealthy, 41
n = 1
Health Status: unhealthy
Condition: Epilepsy
Age Group: 41
Sex: M
Population Size: 1
Sources: Page: 110000
Somnolence 40%
DLT
120 mg/kg 1 times / day multiple, intravenous
Highest studied dose
Dose: 120 mg/kg, 1 times / day
Route: intravenous
Route: multiple
Dose: 120 mg/kg, 1 times / day
Sources: Page: p.179
unhealthy, 62.5
n = 5
Health Status: unhealthy
Condition: Cancer
Age Group: 62.5
Sex: M+F
Population Size: 5
Sources: Page: p.179
Hepatotoxicity Disc. AE
60 mg/kg 1 times / day multiple, oral
Recommended
Dose: 60 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 60 mg/kg, 1 times / day
Sources: Page: p.1
unhealthy
Health Status: unhealthy
Condition: Seizures
Sources: Page: p.1
Pancreatitis Disc. AE
60 mg/kg 1 times / day multiple, oral
Recommended
Dose: 60 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 60 mg/kg, 1 times / day
Sources: Page: p.1
unhealthy
Health Status: unhealthy
Condition: Seizures
Sources: Page: p.1
Overview

Overview

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
minimal
minimal
minimal
no
weak [Ki 7975 uM]
weak [Ki 8553 uM]
weak [Ki 9150 uM]
yes [Ki 600 uM]
likely (co-administration study)
Comment: competitive inhibition; risk of pharmacokinetic drug–drug interactions should be taken into account during concomitant use of valproic acid and CYP2C9 substrates
Drug as victim
PubMed

PubMed

TitleDatePubMed
Hepatic encephalopathy associated with combined clozapine and divalproex sodium treatment.
1997 Apr
Assessment of colour vision in epileptic patients exposed to single-drug therapy.
1999
Clumsiness, confusion, coma, and valproate.
1999 Apr 24
Phenelzine-induced sexual dysfunction treated with sildenafil.
1999 Apr-Jun
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
1999 Aug
Adverse effects of pindolol augmentation in patients with bipolar depression.
1999 Aug
[Encephalopathies caused by valproate].
1999 Jan
N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs.
1999 Jan
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
1999 Jul
Elimination of oxcarbazepine-induced oculogyric crisis following vagus nerve stimulation.
1999 Jun 10
Risperidone-induced mania.
1999 Mar
Anticonvulsants for soman-induced seizure activity.
1999 Mar-Apr
Extrapyramidal symptoms associated with the adjunct of nortriptyline to a venlafaxine-valproic acid combination.
1999 May
Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.
2000 Feb
A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.
2000 Feb
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.
2000 Jan 11
Valproic acid-induced alterations in growth and neurotrophic factor gene expression in murine embryos [corrected].
2000 Jan-Feb
Phenytoin poisoning after using Chinese proprietary medicines.
2000 Jul
Visual and auditory hallucinations with the association of bupropion and valproate.
2000 Mar
Testosterone abuse and affective disorders.
2000 Mar
Gabapentin prophylaxis of clozapine-induced seizures.
2000 Mar
Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism.
2000 May-Jun
Acute hepatitis after lamotrigine administration.
2000 Sep
Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study.
2000 Sep
Action of valproic acid on Xenopus laevis development: teratogenic effects on eyes.
2001
Probenecid-associated alterations in valproate glucuronide hepatobiliary disposition: mechanistic assessment using mathematical modeling.
2001 Apr
Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
2001 Apr
Determination of the antiepileptics vigabatrin and gabapentin in dosage forms and biological fluids using Hantzsch reaction.
2001 Feb
Valproate and the risk of hyperandrogenism.
2001 Feb
Collaborative study on rat sperm motion analysis using CellSoft Series 4000 semen analyzer.
2001 Feb
A case of chronic pancreatic insufficiency due to valproic acid in a child.
2001 Feb
Recommendations for the management of behavioral and psychological symptoms of dementia.
2001 Feb
Treatment of impulsivity and aggression in a patient with vascular dementia.
2001 Feb
Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line.
2001 Jan
Clozapine therapy for a patient with a history of Hodgkin's disease.
2001 Jan
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
2001 Jan 15
[Febrile pleuropericarditis during valproic acid treatment].
2001 Jan 20
A 25-year-old woman with bipolar disorder.
2001 Jan 24-31
Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.
2001 Jan 9
Does genomic imprinting contribute to valproic acid teratogenicity?
2001 Jan-Feb
Naltrexone as a treatment of self-injurious behavior--a case report.
2001 Mar
Patents

Sample Use Guides

Usual Adult Dose for Epilepsy Complex partial seizures: Initial dose: 10 to 15 mg/kg orally or intravenously per day as an IV infusion in divided doses, increased by 5 to 10 mg/kg per week if necessary according to clinical response Maintenance dose: 10 to 60 mg/kg per day in divided doses Maximum dose: 60 mg/kg per day Simple and complex absence seizures: Initial dose: 15 mg/kg orally or intravenously per day as an IV infusion in divided doses, increased at one week intervals by 5 to 10 mg/kg/day according to seizure control and tolerability Maximum dose: 60 mg/kg per day Comments: -If the total daily dose exceeds 250 mg, it should be given in 2 to 3 divided doses. -Use of IV valproate sodium for periods longer than 14 days has not been studied; patients should be converted to oral valproate as soon as clinically feasible. -When switching from oral to IV valproate, the total daily dose of IV valproate should be equivalent to the total daily dose of oral valproate, and administered at the same frequency as the oral product. -Equivalence between IV and oral valproate products at steady state has only been evaluated in a 6-hourly dosing regimen. Trough plasma level monitoring may be required if IV valproate is administered 2 to 3 times a day. -Complex partial seizures: When converting patients to valproate monotherapy, concomitant antiepileptic drug dosage can generally be reduced by approximately 25% every 2 weeks, commencing either at the start of valproate therapy or delayed by 1 to 2 weeks. Patients should be monitored closely during this period for increased seizure frequency. Uses: Monotherapy and adjunctive therapy in the treatment of complex partial seizures; sole and adjunctive therapy for simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures. Usual Adult Dose for Mania Delayed-release capsules : Initial dose: 750 mg orally per day in divided doses Maximum dose: 60 mg/kg orally per day Duration: Safety and efficacy beyond 3 weeks has not been established Comments: -The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effect or the desired range of plasma concentrations. -In placebo-controlled clinical trials of acute mania, patients were dosed to a clinical response with a trough plasma concentration of 50 to 125 mcg/mL. -Maximum concentrations were generally achieved within 14 days. -Safety and efficacy for longer term use in the maintenance of the initial response and prevention of new manic episodes has not been systematically evaluated in clinical trials. Use for extended periods should be accompanied by regular review for the long-term usefulness of the drug for the individual patient. Use: Treatment of manic episodes associated with bipolar disorder. Usual Adult Dose for Migraine Prophylaxis Delayed release oral capsules: Initial dose: 250 mg orally twice a day Comments: -Some patients may benefit from doses up to 1000 mg per day. -In clinical trials, there was no evidence that higher doses led to greater efficacy. Usual Pediatric Dose for Epilepsy 10 years of age or older: Complex partial seizures: Initial dose: 10 to 15 mg/kg orally or intravenously per day as an IV infusion in divided doses, increased by 5 to 10 mg/kg per week if necessary according to clinical response Maintenance dose: 10 to 60 mg/kg per day in divided doses Maximum dose: 60 mg/kg per day Simple and complex absence seizures: Initial dose: 15 mg/kg orally or intravenously per day as an IV infusion in divided doses, increased at one week intervals by 5 to 10 mg/kg/day according to seizure control and tolerability Maximum dose: 60 mg/kg per day Comments: -If the total daily dose exceeds 250 mg, it should be given in 2 to 3 divided doses. -Use of IV valproate sodium for periods longer than 14 days has not been studied; patients should be converted to oral valproate as soon as clinically feasible. -When switching from oral to IV valproate, the total daily dose of IV valproate should be equivalent to the total daily dose of oral valproate, and administered at the same frequency as the oral product. -Equivalence between IV and oral valproate products at steady state has only been evaluated in a 6-hourly dosing regimen. Trough plasma level monitoring may be required if IV valproate is administered 2 to 3 times a day. -Complex partial seizures: When converting patients to valproate monotherapy, concomitant antiepileptic drug dosage can generally be reduced by approximately 25% every 2 weeks, commencing either at the start of valproate therapy or delayed by 1 to 2 weeks. Patients should be monitored closely during this period for increased seizure frequency. Uses: Monotherapy and adjunctive therapy in the treatment of complex partial seizures; sole and adjunctive therapy for simple and complex absence seizures; adjunctive therapy in patients with multiple seizure types that include absence seizures.
Route of Administration: Other
H9C2 cells were cultured and allotted to the blank, vehicle, and valproic acid (VPA)-treated groups: the VPA treated group received VPA exposure at concentrations of 2.0, 4.0 and 8.0 mmol/L. VPA might result in acetylation/deacetylation imbalances by inhibiting HDAC1-3 protein expression and total HDAC activity, leading to the down-regulation of mRNA and protein expression of Vangl2 and Scrib.
Name Type Language
VALPROATE SODIUM
ORANGE BOOK   USAN   USP   VANDF   WHO-DD  
USAN  
Official Name English
SODIUM VALPROATE [WHO-IP]
Common Name English
PENTANOIC ACID, 2-PROPYL-, SODIUM SALT
Common Name English
DEPACON
Brand Name English
NSC-732626
Code English
VALPROIC ACID SODIUM SALT (1:1)
MI  
Common Name English
VALPROIC ACID SODIUM SALT (1:1) [MI]
Common Name English
SODIUM VALPROATE
EP   MART.   WHO-IP  
Systematic Name English
ABBOTT-44090
Code English
Valproate sodium [WHO-DD]
Common Name English
NATRII VALPROAS [WHO-IP LATIN]
Common Name English
VALPROIC ACID, SODIUM
Common Name English
KW-6066N
Code English
SODIUM VALPROATE [MART.]
Common Name English
SELENICA
Brand Name English
VALPROATE SODIUM [USAN]
Common Name English
SODIUM VALPROATE [JAN]
Common Name English
A-44090
Code English
SODIUM 2-PROPYLPENTANOATE [WHO-IP]
Common Name English
SODIUM VALPROATE [EP MONOGRAPH]
Common Name English
NSC-757376
Code English
Sodium 2-propylvalerate
Systematic Name English
VALPROATE SODIUM [USP IMPURITY]
Common Name English
VALPROATE SODIUM [VANDF]
Common Name English
VALPROIC ACID, SODIUM SALT
Common Name English
VALPROATE SODIUM [ORANGE BOOK]
Common Name English
ABBOTT 44090
Code English
Classification Tree Code System Code
EU-Orphan Drug EU/3/04/246
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
NCI_THESAURUS C264
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
FDA ORPHAN DRUG 486515
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
FDA ORPHAN DRUG 200705
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
FDA ORPHAN DRUG 729920
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C48029
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
NSC
757376
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
CHEBI
9925
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
ECHA (EC/EINECS)
213-961-8
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
RXCUI
9919
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m11369
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY Merck Index
WHO INTERNATIONAL PHARMACOPEIA
VALPROATE SODIUM
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Freely soluble in water and ethanol (~750 g/l) TS. Category: Antiepileptic drug. Storage: Sodium valproate should be kept in a well-closed container. Additional information: Sodium valproate is deliquescent. Definition: Sodium valproate contains not less than 98.0% and not more than 101.0% of C8H15NaO2, calculated with reference to the dried substance.
DRUG BANK
DBSALT001257
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
NSC
732626
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
EPA CompTox
DTXSID5037072
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
SMS_ID
100000091448
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
FDA UNII
5VOM6GYJ0D
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
WIKIPEDIA
SODIUM VALPROATE
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
CAS
1069-66-5
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
DAILYMED
5VOM6GYJ0D
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
ChEMBL
CHEMBL109
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
PUBCHEM
16760703
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY
EVMPD
SUB12318MIG
Created by admin on Fri Dec 15 15:35:11 GMT 2023 , Edited by admin on Fri Dec 15 15:35:11 GMT 2023
PRIMARY