2-DIETHYLAMINOETHYL 4-BUTYLAMINOBENZOATE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H28N2O2.ClH
Molecular Weight	328.877
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 2-DIETHYLAMINOETHYL 4-BUTYLAMINOBENZOATE HYDROCHLORIDE

Structure Search

SMILES

Cl.CCCCNC1=CC=C(C=C1)C(=O)OCCN(CC)CC

InChI

InChIKey=XTIUAXFQEAMQRU-UHFFFAOYSA-N

InChI=1S/C17H28N2O2.ClH/c1-4-7-12-18-16-10-8-15(9-11-16)17(20)21-14-13-19(5-2)6-3;/h8-11,18H,4-7,12-14H2,1-3H3;1H

HIDE SMILES / InChI

Description
Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01967https://www.ncbi.nlm.nih.gov/pubmed/26302690
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/10551118

p-Butylaminobenzoyldiethylaminoethyl hydrochloride (T-cain) was the most frequently used local anesthetic for spinal anesthesia in Japan in the 1940s–1960s. The market for spinally administered T-cain is almost ended. T-cain is still used for topical/infiltrative anesthesia in some specialties. T-cain may also be used as an alternative in patients who are allergic to lidocaine or bupivacaine. The side effects reported for spinal use of Neo Percamin S (T-cain with dibucaine) were hypotension, bradycardia, respiratory arrest, and allergy.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26302690	Palliative		Approved 8429	Neo-Percamin S Approved Use T-cain was approved in May 1950 for spinal use. the use of T-cain for topical and/or infiltrative use has been expanding in otorhynolaryngology and ophthalmology.

PubMed

Title	Date	PubMed
[Postoperative pain control after thoracic surgery with depolipone].	1955 Jan	14382373
[Clinical results on pulp devitalization of the deciduous teeth with Neoarsen Black].	1967 Jun	5236121
Fluid behavior of root canal paste (Part 2). Fluid behavior of Calvital.	1985 Jun	3879997
Determination of ester-type local anesthetic drugs (procaine, tetracaine, and T-caine) in human serum by wide-bore capillary gas chromatography with nitrogen-phosphorus detection.	1996 Sep	8872242
Calcium hydroxide pastes: classification and clinical indications.	1999 Aug	10551118
History of T-cain: a local anesthetic developed and manufactured in Japan.	2015 Oct	26302690

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

2-DIETHYLAMINOETHYL 4-BUTYLAMINOBENZOATE HYDROCHLORIDE

Systematic Name

English

P-BUTYLAMINOBENZOYLDIETHYLAMINOETHYL HCL

Common Name

English

DIETHYLAMINOETHYL P-BUTYLAMINOBENZOATE HYDROCHLORIDE [JAN]

Common Name

English

TEECAINE

Brand Name

English

4-(BUTYLAMINO)-2(DIETHYLAMINO)ETHYL ESTER BENZOIC ACID MONOCHLORIDE

Common Name

English

2-(DIETHYLAMINO)ETHYL P-(BUTYLAMINO)BENZOATE HYDROCHLORIDE

Common Name

English

4-Diethylaminoethyl 4-butylaminobenzoate hydrochloride [WHO-DD]

Common Name

English

P-BUTYLAMINOBENZOYLDIETHYLAMINOETHYL HYDROCHLORIDE

Common Name

English

T CAIN

Brand Name

English

T-CAIN

Brand Name

English

DIETHYLAMINOETHYL P-BUTYLAMINOBENZOATE HYDROCHLORIDE

Common Name

English

FARMODENT

Brand Name

English

DEPOLIPON

Brand Name

English

CALVITAL LIQUID

Brand Name

English

Code System Code Type Description

PUBCHEM

27891