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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H44NO6S.Na
Molecular Weight 521.6875
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM TAURODEOXYCHOLATE

SMILES

C[C@]([H])(CCC(=NCCS(=O)(=O)O)[O-])[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@@]([H])(CC[C@]4(C)[C@@]3([H])C[C@@]([H])([C@]12C)O)O.[Na+]

InChI

InChIKey=YXHRQQJFKOHLAP-FVCKGWAHSA-M
InChI=1S/C26H45NO6S.Na/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;/m1./s1

HIDE SMILES / InChI

Description
Curator's Comment:: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/25664595 | https://www.ncbi.nlm.nih.gov/pubmed/23592128 | https://www.ncbi.nlm.nih.gov/pubmed/20522594

Sodium taurodeoxycholate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It is formed by the conjugation of ursodeoxycholic acid (UDCA) with taurine. Sodium taurodeoxycholate and ursodeoxycholic acid are major constituents of black bear bile, which has been used in traditional Chinese medicine for thousands of years. Bear bile was historically employed to treat a number of diseases including jaundice, summer diarrhea, abdominal pain due to hepatobiliary diseases and gastric malfunction, biliary ascariasis, infectious skin diseases, the common cold, intestinal worms, and inflammation of the throat. Sodium taurodeoxycholate has been shown to inhibit apoptosis by modulating mitochondrial membrane perturbation and pore formation, B cell lymphoma 2 (Bcl-2)-associated protein X (BAX) translocation, cytochrome c release, and caspase activation. Sodium taurodeoxycholate inhibits amyloid beta (Ab)-induced apoptosis and attenuates the endoplasmic reticulum (ER) stress, which are thought to be key components of the pathological process in certain diseases. In clinical studies, Sodium taurodeoxycholate is shown to be very safe with oral administration of 1500 mg/day for up to 6 months. In a more recent clinical study, a dose of 1750 mg/day for up to 4 weeks was well tolerated in healthy obese persons. One of the major adverse effects of Sodium taurodeoxycholate is diarrhea. Based on the related information from ursodeoxycholic acid, other gastrointestinal side effects are possible including abdominal pain, flatulence, nausea, dyspepsia, and anorexia.

Originator

Sources: Z. physiol. Chem. (1919), 106, 181-90.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
680.0 nM [EC50]
60.0 µM [IC50]
Target ID: gallbladder eicosanoid release
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [Ki 17.2 uM]
Drug as victim
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Inhibition of MRP1-mediated efflux in human erythrocytes by mono-anionic bile salts.
2005 Sep-Oct
Purification and characterization of the first reptile pancreatic lipase: the turtle.
2008 Apr
Store-operated Ca(2+) channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells.
2008 May
Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability.
2011 Dec
Patents

Patents

Sample Use Guides

Tauroursodeoxycholic acid 1 g twice daily by mouth
Route of Administration: Oral
In Vitro Use Guide
Isolated rat hepatocytes were cultured in uncoated culture dishes (1x10^6 cells per plate) and treated with bile acids for 4 to 24 h. After treatment, the tissue-culture supernatant was harvested and assayed for enzymatic activity of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST). Enzymatic activity was determined in accordance with standard techniques, using commercially available standard kits (Boehringer Mannheim, Germany).
Name Type Language
SODIUM TAURODEOXYCHOLATE
Common Name English
TAURODEOXYCHOLIC ACID SODIUM SALT
Common Name English
ETHANESULFONIC ACID, 2-(((3.ALPHA.,5.BETA.,12.ALPHA.)-3,12-DIHYDROXY-24-OXOCHOLAN-24-YL)AMINO)-, MONOSODIUM SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
Code System Code Type Description
PUBCHEM
23664773
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY
NCI_THESAURUS
C80659
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY
CAS
1180-95-6
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY
FDA UNII
5PE424S83L
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY
RXCUI
1364852
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY RxNorm
ECHA (EC/EINECS)
214-652-0
Created by admin on Fri Jun 25 23:08:00 UTC 2021 , Edited by admin on Fri Jun 25 23:08:00 UTC 2021
PRIMARY