PARGOLOL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H23NO3
Molecular Weight	277.3587
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PARGOLOL

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=C(OCC#C)C=CC=C1

InChI

InChIKey=UFNAECVCKNHAKN-UHFFFAOYSA-N

InChI=1S/C16H23NO3/c1-5-10-19-14-8-6-7-9-15(14)20-12-13(18)11-17-16(2,3)4/h1,6-9,13,17-18H,10-12H2,2-4H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6110251

Pargolol (also Kö 1400) is a beta-adrenergic receptor blocking agent that was developed as an antiarrhythmic agent. However, information about the further development of this drug is not available.

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Drug effects on blood pressure and heart rate in unanesthetized animals. (1). Effects of beta-blocking agents (author's transl)].	1977 May	20392
Antiarrhythmic effect of oxprenolol on halothane-epinephrine and coronary ligation induced ventricular arrhythmias in beagle dogs.	1978 Aug	32416

Name

Type

Language

PARGOLOL

Official Name

English

2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-(2-(2-PROPYN-1-YLOXY)PHENOXY)-

Systematic Name

English

1-(TERT-BUTYLAMINO)-3-(O-(2-PROPYNYLOXY)PHENOXY)-2-PROPANOL

Common Name

English

pargolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

Code System Code Type Description

PUBCHEM

68673

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SMS_ID

100000082816

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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EPA CompTox

DTXSID80866126

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EVMPD

SUB09625MIG

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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FDA UNII

5OPO851W5L

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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NCI_THESAURUS

C66321

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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CAS

47082-97-3

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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INN

4070

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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ChEMBL

CHEMBL1742410

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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MESH

C013364

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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WIKIPEDIA

Pargolol

Created by admin on Fri Dec 15 16:37:26 GMT 2023 , Edited by admin on Fri Dec 15 16:37:26 GMT 2023

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ACTIVE MOIETY


					5OPO851W5L

PARGOLOL