BENDACALOL MESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H23NO6.CH4O3S
Molecular Weight	469.505
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.O[C@@H](CNC[C@@H](O)[C@@H]1COC2=CC=CC=C2O1)[C@H]3COC4=CC=CC=C4O3

InChI

InChIKey=TWESTNYMJIMXRF-AIMMJYJASA-N

InChI=1S/C20H23NO6.CH4O3S/c22-13(19-11-24-15-5-1-3-7-17(15)26-19)9-21-10-14(23)20-12-25-16-6-2-4-8-18(16)27-20;1-5(2,3)4/h1-8,13-14,19-23H,9-12H2;1H3,(H,2,3,4)/t13-,14+,19+,20-;

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2863983 | https://www.ncbi.nlm.nih.gov/pubmed/2874174

Bendacalol (also known as CGS 10078B) is an alpha- and beta-adrenergic receptor inhibitor with calcium entry blocking effect was studied for the treatment of hypertension. Animal experiments have sown some positive results. However, information about further studies is not available.

Approval Year

PubMed

Title	Date	PubMed
Protection of CGS 10078B against ouabain-induced arrhythmia in the cat.	1987	2888137
The effect of prolonged administration of CGS 10078B on systemic and regional haemodynamics in normotensive and spontaneously hypertensive rats.	1986-06	2874174
Hemodynamic effects of a new alpha- and beta-adrenergic receptor inhibitor with calcium entry blocking effects (CGS 10078B) in WKY and SHR rats.	1985-08	2863983

Patents

Name

Type

Language

BENDACALOL MESYLATE

Official Name

English

CGS 10078B

Preferred Name

English

BENDACALOL MESYLATE [USAN]

Common Name

English

1,4-BENZODIOXIN-2-METHANOL, .ALPHA.,.ALPHA.'-(IMINOBIS(METHYLENE))BIS(2,3-DIHYDRO-, (2R*(S*(R*(S*))))-, METHANESULPHONATE (SALT)

Common Name

English

CGS-10078B

Code

English

1,4-BENZODIOXIN-2-METHANOL, .ALPHA.,.ALPHA.'-(IMINOBIS(METHYLENE))BIS(2,3-DIHYDRO-, (2R*(S*(R*(S*))))-, METHANESULFONATE (SALT)

Common Name

English

BENDACALOL MESILATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C72900