U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H23NO6
Molecular Weight 373.3997
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENDACALOL

SMILES

O[C@@H](CNC[C@@H](O)[C@@H]1COC2=CC=CC=C2O1)[C@H]3COC4=CC=CC=C4O3

InChI

InChIKey=JMVGSDHINNGCAC-GOFCXKROSA-N
InChI=1S/C20H23NO6/c22-13(19-11-24-15-5-1-3-7-17(15)26-19)9-21-10-14(23)20-12-25-16-6-2-4-8-18(16)27-20/h1-8,13-14,19-23H,9-12H2/t13-,14+,19+,20-

HIDE SMILES / InChI
Molecular Formula C20H23NO6
Molecular Weight 373.3997
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Bendacalol (also known as CGS 10078B) is an alpha- and beta-adrenergic receptor inhibitor with calcium entry blocking effect was studied for the treatment of hypertension. Animal experiments have sown some positive results. However, information about further studies is not available.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Protection of CGS 10078B against ouabain-induced arrhythmia in the cat.
1987
The effect of prolonged administration of CGS 10078B on systemic and regional haemodynamics in normotensive and spontaneously hypertensive rats.
1986-06
Hemodynamic effects of a new alpha- and beta-adrenergic receptor inhibitor with calcium entry blocking effects (CGS 10078B) in WKY and SHR rats.
1985-08
Patents

Patents

4313955
2
Substance Class Chemical
Created
by admin
on Wed Apr 02 06:52:42 GMT 2025
Edited
by admin
on Wed Apr 02 06:52:42 GMT 2025
Record UNII
BQ0I558X42
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
bendacalol [INN]
Preferred Name English
BENDACALOL
INN  
INN  
Official Name English
Classification Tree Code System Code
NCI_THESAURUS C72900
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
Code System Code Type Description
PUBCHEM
10434826
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
INN
6097
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110643
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
NCI_THESAURUS
C79912
Created by admin on Wed Apr 02 06:52:42 GMT 2025 , Edited by admin on Wed Apr 02 06:52:42 GMT 2025
PRIMARY
SMS_ID
100000086594
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
CAS
81703-42-6
Created by admin on Wed Apr 02 06:52:42 GMT 2025 , Edited by admin on Wed Apr 02 06:52:42 GMT 2025
PRIMARY
FDA UNII
BQ0I558X42
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
EPA CompTox
DTXSID20231253
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
EVMPD
SUB05706MIG
Created by admin on Wed Apr 02 06:52:43 GMT 2025 , Edited by admin on Wed Apr 02 06:52:43 GMT 2025
PRIMARY
Related Record Type Details
Structure of BENDACALOL
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966