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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H22O7
Molecular Weight 374.3845
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of WIKSTROMOL

SMILES

COC1=C(O)C=CC(C[C@@H]2COC(=O)[C@@]2(O)CC3=CC(OC)=C(O)C=C3)=C1

InChI

InChIKey=ZITBJWXLODLDRH-JLTOFOAXSA-N
InChI=1S/C20H22O7/c1-25-17-8-12(3-5-15(17)21)7-14-11-27-19(23)20(14,24)10-13-4-6-16(22)18(9-13)26-2/h3-6,8-9,14,21-22,24H,7,10-11H2,1-2H3/t14-,20-/m1/s1

HIDE SMILES / InChI

Description

Wikstromol is the enantiomer of nortrachelogenin, isolated from Trachelospermum asiaticum var. intermedium and Pinus palustris. Wikstromol exhibited acetylcholinesterase (AChE) inhibitory. It has been found to be active against P-388 lymphocytic leukemia growth implanted in mice. The reason for this is at present unclear, although it is possible that wikstromol is either metabolized to an active antileukemic agent by the host or else serves as a biological response modifier.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Mice: 60 or 100 mg/30 mg of thiopental
Route of Administration: Unknown
In Vitro Use Guide
Wikstromol demonstrated moderate activity against HIV-1 in vitro with IC(50)s ranger from 4.02 to 5.74 uM.