Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H22O7 |
| Molecular Weight | 374.3845 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(O)C=CC(C[C@@H]2COC(=O)[C@@]2(O)CC3=CC(OC)=C(O)C=C3)=C1
InChI
InChIKey=ZITBJWXLODLDRH-JLTOFOAXSA-N
InChI=1S/C20H22O7/c1-25-17-8-12(3-5-15(17)21)7-14-11-27-19(23)20(14,24)10-13-4-6-16(22)18(9-13)26-2/h3-6,8-9,14,21-22,24H,7,10-11H2,1-2H3/t14-,20-/m1/s1
| Molecular Formula | C20H22O7 |
| Molecular Weight | 374.3845 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Wikstromol is the enantiomer of nortrachelogenin, isolated from Trachelospermum asiaticum var. intermedium and Pinus palustris. Wikstromol exhibited acetylcholinesterase (AChE) inhibitory. It has been found to be active against P-388 lymphocytic leukemia growth implanted in mice. The reason for this is at present unclear, although it is possible that wikstromol is either metabolized to an active antileukemic agent by the host or else serves as a biological response modifier.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Enantioselective synthesis of (-)-wikstromol using a new approach via malic acid. | 2001-04-06 |
|
| Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. | 2000-08 |
|
| Stereoselectivity questions in the synthesis of wikstromol. | 1990-11-01 |
|
| Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica. | 1981-09-01 |
|
| (+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. | 1979-03-01 |
|
| (+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. | 1979-03-01 |
|
| (+)-Nortrachelogenin, A New Pharmacologically Active Lignan From Wikstroemia indica. | 1979-03 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:13:38 GMT 2025
by
admin
on
Mon Mar 31 22:13:38 GMT 2025
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| Record UNII |
5HG1T9G09U
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| Record Status |
Validated (UNII)
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| Record Version |
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5HG1T9G09U
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61521-74-2
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479756
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DTXSID70977093
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admin on Mon Mar 31 22:13:38 GMT 2025 , Edited by admin on Mon Mar 31 22:13:38 GMT 2025
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