Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H22O7 |
| Molecular Weight | 374.3845 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(O)C=CC(C[C@@H]2COC(=O)[C@@]2(O)CC3=CC(OC)=C(O)C=C3)=C1
InChI
InChIKey=ZITBJWXLODLDRH-JLTOFOAXSA-N
InChI=1S/C20H22O7/c1-25-17-8-12(3-5-15(17)21)7-14-11-27-19(23)20(14,24)10-13-4-6-16(22)18(9-13)26-2/h3-6,8-9,14,21-22,24H,7,10-11H2,1-2H3/t14-,20-/m1/s1
| Molecular Formula | C20H22O7 |
| Molecular Weight | 374.3845 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Wikstromol is the enantiomer of nortrachelogenin, isolated from Trachelospermum asiaticum var. intermedium and Pinus palustris. Wikstromol exhibited acetylcholinesterase (AChE) inhibitory. It has been found to be active against P-388 lymphocytic leukemia growth implanted in mice. The reason for this is at present unclear, although it is possible that wikstromol is either metabolized to an active antileukemic agent by the host or else serves as a biological response modifier.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| (+)-Nortrachelogenin, A New Pharmacologically Active Lignan From Wikstroemia indica. | 1979 Mar |
|
| (+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. | 1979 Mar-Apr |
|
| (+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. | 1979 Mar-Apr |
|
| Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica. | 1981 Sep-Oct |
|
| Stereoselectivity questions in the synthesis of wikstromol. | 1990 Nov-Dec |
|
| Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. | 2000 Aug |
|
| Enantioselective synthesis of (-)-wikstromol using a new approach via malic acid. | 2001 Apr 6 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:38:28 GMT 2023
by
admin
on
Sat Dec 16 08:38:28 GMT 2023
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| Record UNII |
5HG1T9G09U
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| Record Status |
Validated (UNII)
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| Record Version |
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61521-74-2
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479756
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DTXSID70977093
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