Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Na.O4Se |
Molecular Weight | 188.94 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-][Se]([O-])(=O)=O
InChI
InChIKey=MHQOTKLEMKRJIR-UHFFFAOYSA-L
InChI=1S/2Na.H2O4Se/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/19827742Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24323428 | https://www.ncbi.nlm.nih.gov/pubmed/26468123 | https://www.ncbi.nlm.nih.gov/pubmed/25485856
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19827742
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24323428 | https://www.ncbi.nlm.nih.gov/pubmed/26468123 | https://www.ncbi.nlm.nih.gov/pubmed/25485856
SELENATE ION is a compound containing an oxoanion with selenium in its highest oxidation state of VI. Selenates are analogous to sulfates and have similar chemistry, but unlike sulfate, selenate is a good oxidizer. Selenate is the form required by organisms that need selenium as a micronutrient. These organisms have the ability to acquire, metabolize and excrete selenium. The level at which selenium becomes toxic varies from species to species and is related to other environmental factors like pH and alkalinity that influence the concentration of selenite over selenate. Selenate and other forms of selenium are highest in areas where ancient seas have evaporated. These areas are enriched in selenium and over millennia, biologic adaptation has occurred.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: WP402 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18547722 |
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Target ID: CHEMBL4703 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20643941 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00271245
200-400 µg selenium as selenate
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25485856
N2aSW cell viability was detected by the CCK-8 assay. Briefly, N2aSW cells (5X10^3 per well) exposed to sodium selenate at a set of concentrations (0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 mmol/L in FBS-free medium) were grown in 96-well-plates for 24 h. 10% CCK-8 reagent was added to each well and the cells were incubated at 37°C for another 2 h. Cells without sodium selenate treatment were used as the control. The absorbance at 450 nm was measured with a reference wavelength of 650 nm by SpecTRA MAX 190 microplate reader (Molecular Devices, Sunnyvale, CA, USA). All experiments were performed in triplicates.
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C275
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WHO-VATC |
QA12CE01
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EPA PESTICIDE CODE |
72002
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WHO-ATC |
A12CE01
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36717
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C1229
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5DQP25600A
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4781
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C021747
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DTXSID5032076
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100000085993
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SODIUM SELENATE
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m10070
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DBSALT002579
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13410-01-0
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5DQP25600A
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25960
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77775
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236-501-8
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6370
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SUB22098
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378348
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CHEMBL2097002
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD