PAFENOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H31N3O3
Molecular Weight	337.457
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)COC1=CC=C(CCNC(=O)NC(C)C)C=C1

InChI

InChIKey=PKWZWSXSCKVUJB-UHFFFAOYSA-N

InChI=1S/C18H31N3O3/c1-13(2)20-11-16(22)12-24-17-7-5-15(6-8-17)9-10-19-18(23)21-14(3)4/h5-8,13-14,16,20,22H,9-12H2,1-4H3,(H2,19,21,23)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6129091 | https://adisinsight.springer.com/drugs/800002399

Pafenolol is a beta 1 selective adrenoceptor blocker that was studied in phase I clinical trial in Sweden for the treatment of arrhythmia. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction.

Route of Administration: Intravenous

Name

Type

Language

PAFENOLOL

Official Name

English

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-

Systematic Name

English

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-, (±)-

Common Name

English

Pafenolol [WHO-DD]

Common Name

English

(±)-1-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)-3-ISOPROPYLUREA

Common Name

English

pafenolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576