U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C24H27NO2
Molecular Weight 361.4767
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OCTOCRYLENE

SMILES

CCCCC(CC)COC(=O)C(C#N)=C(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=FMJSMJQBSVNSBF-UHFFFAOYSA-N
InChI=1S/C24H27NO2/c1-3-5-12-19(4-2)18-27-24(26)22(17-25)23(20-13-8-6-9-14-20)21-15-10-7-11-16-21/h6-11,13-16,19H,3-5,12,18H2,1-2H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including, http://onlinelibrary.wiley.com/doi/10.1111/cod.12205/epdf

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene is also often combined with avobenzone, another common sunscreen ingredient often appearing on ingredient labels. Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skin care products, but the concentrations of this ingredient are usually limited to no more than 10 or 12 percent. However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend to a variety of other products, like hair spray, tannin oil, BB cream, conditioner, and CC cream, among others. Octocrylene may cause contact and photocontact allergy.

Originator

Gers-Barlag, H.|Miller, A.
1
Curator's Comment: http://143230426296262911.weebly.com/introduction-to-molecule.html

Approval Year

2004
216
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8583
ANTHELIOS 20

Approved Use

Help prevent sunburns.

Launch Date

2006
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
7.8 ng/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g 4 times / day steady-state, topical
dose: 2.7 g
route of administration: Topical
experiment type: STEADY-STATE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
3.7 ng/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g single, topical
dose: 2.7 g
route of administration: Topical
experiment type: SINGLE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
43.3 h
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/31058986
2.7 g 4 times / day steady-state, topical
dose: 2.7 g
route of administration: Topical
experiment type: STEADY-STATE
co-administered:
OCTOCRYLENE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
3.7 g 1.3 times / day multiple, topical
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Dermatitis, Eczema...
Other AEs:
Dermatitis (2.5%)
Eczema (1.3%)
Sources:
https://www.fda.gov/media/71361/download
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Acne, Dermatitis...
Other AEs:
Acne (4.8%)
Dermatitis (2.8%)
Dry skin (1.2%)
Eczema (1.2%)
Erythema (1.2%)
Pruritus (2%)
Rosacea (0.4%)
Seborrhea (0.8%)
Skin discomfort (1.2%)
Sunburn (0.8%)
Conjunctivitis (0.8%)
Taste perversion (0.4%)
Sources:
https://www.fda.gov/media/71361/download
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Other AEs: Dermatitis, Eczema...
Other AEs:
Dermatitis (2.8%)
Eczema (0.4%)
Erythema (0.8%)
Skin discomfort (0.8%)
Sunburn (1.6%)
Conjunctivitis (0.4%)
Sources:
https://www.fda.gov/media/71361/download
AEs

AEs

AESignificanceDosePopulation
Eczema 1.3%
3.7 g 1.3 times / day multiple, topical
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.5%
3.7 g 1.3 times / day multiple, topical
Recommended
Dose: 3.7 g, 1.3 times / day
Route: topical
Route: multiple
Dose: 3.7 g, 1.3 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 3.69 years (range: 0.64-48.15 years)
Health Status: healthy
Age Group: 3.69 years (range: 0.64-48.15 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Rosacea 0.4%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Taste perversion 0.4%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Conjunctivitis 0.8%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Seborrhea 0.8%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Sunburn 0.8%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Dry skin 1.2%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Eczema 1.2%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Erythema 1.2%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Skin discomfort 1.2%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Pruritus 2%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.8%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Acne 4.8%
1.6 g 1.1 times / day multiple, topical
Recommended
Dose: 1.6 g, 1.1 times / day
Route: topical
Route: multiple
Dose: 1.6 g, 1.1 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 35.44 years (range: 12.04-83.43 years)
Health Status: healthy
Age Group: 35.44 years (range: 12.04-83.43 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Conjunctivitis 0.4%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Eczema 0.4%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Erythema 0.8%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Skin discomfort 0.8%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Sunburn 1.6%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Dermatitis 2.8%
3.1 g 1.2 times / day multiple, topical
Recommended
Dose: 3.1 g, 1.2 times / day
Route: topical
Route: multiple
Dose: 3.1 g, 1.2 times / day
Sources:
https://www.fda.gov/media/71361/download
healthy, 6.69 years (range: 0.5-67.95 years)
Health Status: healthy
Age Group: 6.69 years (range: 0.5-67.95 years)
Sex: M+F
Sources:
https://www.fda.gov/media/71361/download
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
P-gp
301
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
P-gp
1932
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY460449
https://www.001chemical.com/chem/6197-30-4
3B Scientific (Wuhan) Corp
3B3-012187
http://www.3bsc.com/index/pro_info.php?id=34690
AA Blocks
AA00IAVE
http://www.aablocks.com/goods/Goods/detail?id=AA00IAVE
Aaron Chemicals
AR00IBN6
http://www.aaronchem.com/6197-30-4
abcr GmbH
AB140373
http://www.abcr.com/shop/en/AB140373
AbMole Bioscience
M5830
http://www.abmole.com/products/octocrylene.html
Acadechem
ACDS-026798
http://www.acadechemical.com/product/101497
Achemica
ACMC-209myd
http://www.achemica.com/prodinfo/?id=129801
Achemtek
0104-005960
http://www.achemtek.com/6197-30-4
AEchem Scientific Corp., USA
AE031997
http://www.aechemsc.com/info_products/AE031997.php
AK Scientific, Inc. (AKSCI)
J10375
http://www.aksci.com/item_detail.php?cat=J10375
Alfa Chemistry
6197-30-4
https://www.alfa-chemistry.com/octocrilene-cas-6197-30-4-item-283669.htm
Alfa Chemistry
ACM6197304-1
https://materials.alfachemic.com/product/2-ethylhexyl-2-cyano-3-3-diphenylacrylate-cas-6197-30-4-337327.html
Alfa Chemistry
ACM6197304-2
https://materials.alfachemic.com/product/2-ethylhexyl-2-cyano-3-3-cas-6197-30-4-337328.html
Alfa Chemistry
AP6197304-A
https://reagents.alfa-chemistry.com/product/octocrylene-cas-6197-30-4-14166.html
Alfa Chemistry
AP6197304-B
https://reagents.alfa-chemistry.com/product/octocrylene-cas-6197-30-4-14167.html
Ambeed
A201796
https://www.ambeed.com/products/6197-30-4.html
Ambinter
Amb17749058
http://www.ambinter.com/reference/17749058
Angene
AGN-PC-05W3YG
http://www.angenechemical.com/productshow/AGN-PC-05W3YG.html
Anward
ANW-34019
http://www.anward.com/pro_result/6993
Ark Pharm
AK-78708
http://www.arkpharminc.com/products/6197-30-4.html
Avantor Inc
700007-978
https://us.vwr.com/store/product/21573273/2-ethylhexyl-2-cyano-3-3-diphenylacrylate
Avantor Inc
700007-980
https://us.vwr.com/store/product/21573273/2-ethylhexyl-2-cyano-3-3-diphenylacrylate
BioChemPartner
BCP15293
http://www.biochempartner.com/6197-30-4-BCP15293
BioSynth
Q-201499
https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201499.html
BLD Pharm
BD1674
http://www.bldpharm.com/products/6197-30-4.html
Boerchem
BC225072
http://www.boerchem.com/?product_37872.html
Capot Chemical
13147
http://www.capotchem.com/en/13147.htm
Capot Chemical
PubChem13147
http://www.capotchem.com/en/13147.htm
Chem Scene
CS-4296
http://www.chemscene.com/6197-30-4.html
ChemMol
30113285
http://www.chemmol.com/chemmol/30113285.html
ChemMol
44007278
http://www.chemmol.com/chemmol/44007278.html
ChemMol
49403764
http://www.chemmol.com/chemmol/49403764.html
ChemMol
99165642
http://www.chemmol.com/chemmol/99165642.html
Chemspace
CSSB00000041970
https://chem-space.com/CSSB00000041970
Clearsynth
CS-O-11009
https://www.clearsynth.com/en/CSO11009.html
CSNpharm
CSN22918
https://www.csnpharm.com/products/octocrylene.html
eNovation Chemicals
D275724
https://www.enovationchem.com/ProductDetails.asp?ProductID=D275724
Finetech
FT-0612234
http://www.finetechnology-ind.com/prod/detail/pub/6197-30-4.html
Hairui
HR124827
http://www.hairuichem.com/en/product/6197-30-4.html
iChemical
EBD3215
http://www.ichemical.com/chemicals/cas-6197-30-4
Lab Network
LN00195470
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195470
LGC Standards
DRE-C15894510
https://www.lgcstandards.com/US/en/p/DRE-C15894510
LGC Standards
LGCFOR1552.00
https://www.lgcstandards.com/US/en/p/LGCFOR1552.00
LGC Standards
MM1552.00
https://www.lgcstandards.com/US/en/p/MM1552.00
mcule
MCULE-9077867311
https://mcule.com/MCULE-9077867311/
MedChem Express
HY-A0087
https://www.medchemexpress.com/Octocrylene.html
Molcore
MC460449
https://www.molcore.com/product/6197-30-4
MuseChem
I004338
https://www.musechem.com/product/I004338.html
Oakwood
217136
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=98135&ExtHyperLink=1
Parchem
13018
http://www.parchem.com/chemical-supplier-distributor/Octocrylene-003018.aspx
Parchem
26772
http://www.parchem.com/chemical-supplier-distributor/Octocrylene-016772.aspx
Renno Tech
RL04347
http://www.rennotech.com/product_show.asp?id=4596
Sigma-Aldrich
02343_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/02343?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1477411_USP
https://www.sigmaaldrich.com/catalog/product/usp/1477411?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
415820_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/415820?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
PHR1083_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/phr1083?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S011141
http://www.sinfoobiotech.com/product/1014539
Smolecule
S573333
https://www.smolecule.com/products/s573333
TCI (Tokyo Chemical Industry)
C0968
http://www.tcichemicals.com/eshop/en/us/commodity/C0968/index.html
THE BioTek
bt-460979
https://www.thebiotek.com/product/others/bt-460979
VladaChem
VL269317-100G
https://www.vladachem.com/product.php?products=6197-30-4
Yuhao Chemical
XJ3062
http://www.chemyuhao.com/6197-30-4.html
PubMed

PubMed

TitleDatePubMed
Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics.
2010-11
Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.
2010-10-22
Stir-bar-sorptive extraction and ultra-high-performance liquid chromatography-tandem mass spectrometry for simultaneous analysis of UV filters and antimicrobial agents in water samples.
2010-08
Octocrylene, an emerging photoallergen.
2010-07
Physicochemical study on microencapsulation of hydroxypropyl-beta-cyclodextrin in dermal preparations.
2010-06
Emergent and unusual allergens in cosmetics.
2010-05-22
Determination of organic UV filters in water by stir bar sorptive extraction and direct analysis in real-time mass spectrometry.
2010-05
Filter-filter interactions. Photostabilization, triplet quenching and reactivity with singlet oxygen.
2010-04
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.
2010-03
Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.
2010-02
Two cases of photocontact allergy to the new sun filter octocrylene.
2009-12-15
Photostabilization effect of quercetin on the UV filter combination, butyl methoxydibenzoylmethane-octyl methoxycinnamate.
2009-12-02
Ultra-high-performance liquid chromatography-tandem mass spectrometry for determining the presence of eleven personal care products in surface and wastewaters.
2009-10-16
Irradiation of skin and contrasting effects on absorption of hydrophilic and lipophilic compounds.
2009-08-07
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.
2009-07-31
Determination of personal care products in sewage sludge by pressurized liquid extraction and ultra high performance liquid chromatography-tandem mass spectrometry.
2009-07-24
Addressing technical challenges associated with the FDA's proposed rules for the UVA in vitro testing procedure.
2009-06-15
Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
2009-06-12
A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions.
2009-02
Incorporation in lipid microparticles of the UVA filter, butyl methoxydibenzoylmethane combined with the UVB filter, octocrylene: effect on photostability.
2009
In vitro assessments of UVA protection by popular sunscreens available in the United States.
2008-12
Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters.
2008-07
Sunscreens cause coral bleaching by promoting viral infections.
2008-04
Multiclass determination of sunscreen chemicals in water samples by liquid chromatography-tandem mass spectrometry.
2008-02-15
Development of a method for the determination of UV filters in water samples using stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.
2008-02-01
Allergic and photoallergic contact dermatitis from ketoprofen: evaluation of cross-reactivities by a combination of photopatch testing and computerized conformational analysis.
2008
Development of a human in vivo method to study the effect of ultraviolet radiation and sunscreens in melanocytic nevi.
2008
Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E.
2007-10-01
Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant.
2007-08
Study of the efficacy of 18 sun filters authorized in European Union tested in vitro.
2007-06
Determination of UV filters and antimicrobial agents in environmental water samples.
2007-02
A validated method for the determination of traces of UV filters in fish using LC-MS/MS.
2006-11
Sunscreen enhancement of UV-induced reactive oxygen species in the skin.
2006-10-15
Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment.
2006-08
Octocrylene: really non-allergenic?
2006-05
Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants.
2006-03-01
Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.
2006-02
Evaluation of the photostability of different UV filter combinations in a sunscreen.
2006-01-13
Contact allergy to octocrylene in sunscreen with recurrence from passive transfer of a cosmetic.
2005-10
[Estrogenic activity of ultraviolet absorbers and the related compounds].
2005-08
Assay of common sunscreen agents in suncare products by high-performance liquid chromatography on a cyanopropyl-bonded silica column.
2005-06-15
Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes.
2005-02-15
Sunscreens - which and what for?
2004-12-13
Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.
2004-09-28
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
2004-09-17
Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes.
2004-05
Development and validation of a non-aqueous reversed-phase high-performance liquid chromatographic method for the determination of four chemical UV filters in suncare formulations.
2004-03-26
Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.
2004-03-15
Effects of active sunscreen ingredient combinations on the topical penetration of the herbicide 2,4-dichlorophenoxyacetic acid.
2003-02
Contact allergy to octocrylene.
2003-01
Patents

Patents

JP2000229829A
1
JP2008531514A
9
JP2010132647A
1
JP2011506326A
5
JP4740845B2
3
JP4852410B2
16
JPH05194171A
1
JPH07330561A
1

Sample Use Guides

In Vivo Use Guide
Apply 15 minutes before sun exposure.
Route of Administration: Topical
In Vitro Use Guide
The study was performed in vitro using a Franz type diffusion cell. Only one of the products contained octocrylene and the concentration was 70 g/L (~7%). The sunscreen product was applied to human skin (surface area = 1.13 -1.23 cm2). Following 8-hr topical applications of the products it was reported that no octocrylene was detected in the receptor fluid suggesting that penetration through the skin was minimal to non-existent.
Name Type Language
OCTOCRYLENE
INCI   MI   ORANGE BOOK   USAN   USP   USP-RS  
INCI   USAN  
Official Name English
OCTOCRILENE
INN   MART.   WHO-DD  
INN  
Preferred Name English
ANTHELIOS SX COMPONENT OCTOCRYLENE
Common Name English
OCTOCRYLENE [USP MONOGRAPH]
Common Name English
OCTOCRYLENE [USAN]
Common Name English
Octocrilene [WHO-DD]
Common Name English
2-CYANO-3,3-DIPHENYL-2-PROPENOIC ACID, 2-ETHYLHEXYL ESTER
Common Name English
2-Ethylhexyl 2-cyano-3,3-diphenylacrylate
Systematic Name English
CAPITAL SOLEIL COMPONENT OCTOCRYLENE
Common Name English
NSC-760433
Code English
2-PROPENOIC ACID, 2-CYANO-3,3-DIPHENYL-, 2-ETHYLHEXYL ESTER
Common Name English
octocrilene [INN]
Common Name English
OCTOCRYLENE [MI]
Common Name English
OCTOCRYLENE [ORANGE BOOK]
Common Name English
OCTOCRYLENE [USP-RS]
Common Name English
OCTOCRYLENE [USP IMPURITY]
Common Name English
OCTOCRILENE [MART.]
Common Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 217
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
CFR 21 CFR 352.10
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
NCI_THESAURUS C851
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
CFR 21 CFR 352.20
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
Code System Code Type Description
ECHA (EC/EINECS)
228-250-8
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
RS_ITEM_NUM
1477411
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
DRUG CENTRAL
3395
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
MERCK INDEX
m8115
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY Merck Index
INN
4719
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
MESH
C088673
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
PUBCHEM
22571
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
NCI_THESAURUS
C84027
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
CAS
6197-30-4
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
WIKIPEDIA
OCTOCRYLENE
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
EVMPD
SUB09413MIG
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
NSC
760433
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
EPA CompTox
DTXSID9025299
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
SMS_ID
100000083846
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
DAILYMED
5A68WGF6WM
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
ChEMBL
CHEMBL1201147
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
RXCUI
77674
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY RxNorm
FDA UNII
5A68WGF6WM
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
DRUG BANK
DB09535
Created by admin on Mon Mar 31 17:57:45 GMT 2025 , Edited by admin on Mon Mar 31 17:57:45 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of OCTOCRYLENE
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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