LINDANE

US Previously Marketed

First approved in 1951

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6Cl6
Molecular Weight	290.83
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H]1Cl

InChI

InChIKey=JLYXXMFPNIAWKQ-GNIYUCBRSA-N

InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1701516
Curator's Comment: description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf | http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309shampoolbl.pdf

Lindane is an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical. As a shampoo, lindane is used for treamtment lice infestation. Lindane lotion is used for treatment of scabies. Due to toxicities, associated with lindane, it is used only in patients who cannot tolerate or have failed first-line treatment with safer medication. Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova, where it interferes with GABA neurotransmitter function by interacting with the GABAA channel complex at the picrotoxin binding site.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor 3 Target ID: CHEMBL2364024 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1701516	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Lice infestation 6 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309shampoolbl.pdf	Curative		Approved 8583	KWELL Approved Use Lindane Shampoo is indicated for the treatment of head lice (infestations of Pediculus humanus capitis), crab lice (infestations of Pthirus pubis), and their ova only in patients who cannot tolerate other approved therapies, or have failed treatment with other approved therapies. Lindane Shampoo should be used in the context of an overall lice management program that includes: Visual inspection to ensure that the patient is currently infested with live lice (empty egg casings or its can remain on hair shaft long after true infestation). Manual removal of nits using a comb designed for this purpose and/or individual removal with tweezers followed by close examination of the hair and scalp. Evaluation and treatment of sexual contacts simultaneously. Sexual contacts should be prescribed Lindane Shampoo only if they either have failed to respond to adequate doses of other approved therapies or are intolerant of other approved therapies. All recently worn clothing, underwear, pajamas, used sheets, pillowcases, and towels should be washed in very hot water or dry-cleaned. Caregivers applying this product to patients should wear gloves less permeable to Lindane such as nitrile, latex with neoprene or sheer vinyl, and thoroughly clean hands after application. Natural latex gloves should be avoided because they are more permeable to Lindane. Lindane Shampoo does not prevent infestation or reinfestation and should not be used to ward off a possible infestation. Launch Date 1975
Scabies 9 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	Curative		Approved 8583	KWELL LOTION Approved Use Lindane Lotion, USP 1%, is an ectoparasiticide and ovicide. Lindane Lotion, USP 1%, is an ectoparasiticide and ovicide effective against Sarcoptes scabiei (scabies). Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Lindane Lotion is indicated for the treatment of scabies (infestations of Sarcoptes scabei) only in patients who: 1. cannot tolerate other approved therapies, or 2. have failed treatment with other approved therapies. Launch Date 1974

C_max

Value	Dose	Co-administered	Analyte	Population
28 ng/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309shampoolbl.pdf	1 % single, topical dose: 1 % route of administration: Topical experiment type: SINGLE co-administered:		LINDANE blood	Homo sapiens population: UNKNOWN age: CHILD sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
18 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309shampoolbl.pdf	1 % single, topical dose: 1 % route of administration: Topical experiment type: SINGLE co-administered:		LINDANE blood	Homo sapiens population: UNKNOWN age: CHILD sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
1 % multiple, topical Recommended Dose: 1 % Route: topical Route: multiple Dose: 1 % Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	Other AEs: Seizures... Other AEs: Seizures Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf
1 % single, topical Recommended Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	Other AEs: Seizures... Other AEs: Seizures (rare) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf

AEs

AE	Significance	Dose	Population
Seizures		1 % multiple, topical Recommended Dose: 1 % Route: topical Route: multiple Dose: 1 % Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf
Seizures	rare	1 % single, topical Recommended Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087	inducer 440

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
		CYP2B6 669 CYP2R1 1 CYP1B1 71 CYP2A6 86 CYP1A1 151 CYP2C8 198 CYP3A5 92 CYP3A7 15 CYP2S1 1

Drug as perpetrator

Target	Modality	Activity
CYP1A1 272	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP1B1 93	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2A6 911	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2C8 1117	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2C9 2497	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2R1 1	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2S1 1	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP3A5 201	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	likely
CYP2B6 1160	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	yes
CYP3A4 2633	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	yes
CYP3A7 22	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20035023/	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B1-00182	http://www.3bsc.com/index/pro_info.php?id=20394
3B Scientific (Wuhan) Corp	3B2-3297	http://www.3bsc.com/index/pro_info.php?id=76449
3B Scientific (Wuhan) Corp	3B3-062768	http://www.3bsc.com/index/pro_info.php?id=101938
3B Scientific (Wuhan) Corp	3B3-062769	http://www.3bsc.com/index/pro_info.php?id=101939
3B Scientific (Wuhan) Corp	3B3-062770	http://www.3bsc.com/index/pro_info.php?id=101940
AA Blocks	AA00CPXH	https://www.aablocks.com/goods/Goods/detail?id=AA00CPXH
AA Blocks	AA00EVQI	https://www.aablocks.com/goods/Goods/detail?id=AA00EVQI
AbMole Bioscience	M5744	http://www.abmole.com/products/lindane.html
AHH Chemical co.,ltd	MT-26381	http://www.ahhchemical.com/product/MT-26381.html
AK Scientific, Inc. (AKSCI)	7644AF	http://www.aksci.com/item_detail.php?cat=7644AF
AK Scientific, Inc. (AKSCI)	V0158	http://www.aksci.com/item_detail.php?cat=V0158
Alfa Chemistry	1537222	https://www.alfa-chemistry.com/epsilon-hch-cas-6108-10-7-item-292949.htm
Alfa Chemistry	319-85-7	https://www.alfa-chemistry.com/cas_319-85-7.htm
Alfa Chemistry	319-86-8	https://www.alfa-chemistry.com/lindane-cas-319-86-8-item-129317.htm
Alfa Chemistry	AP319868-A	https://reagents.alfa-chemistry.com/product/bhc-cas-319-86-8-9912.html
Alfa Chemistry	AP319868-B	https://reagents.alfa-chemistry.com/product/hch-cas-319-86-8-9913.html
Ambinter	Amb22800474	http://www.ambinter.com/reference/22800474
Ambinter	Amb22800475	http://www.ambinter.com/reference/22800475
Ambinter	Amb22800476	http://www.ambinter.com/reference/22800476
Ambinter	Amb24713699	http://www.ambinter.com/reference/24713699
Ambinter	Amb25195964	http://www.ambinter.com/reference/25195964
Aurora Fine Chemicals LLC	A17.891.026	http://online.aurorafinechemicals.com/info?ID=A17.891.026
Aurora Fine Chemicals LLC	A17.891.094	http://online.aurorafinechemicals.com/info?ID=A17.891.094
Aurora Fine Chemicals LLC	A17.894.822	http://online.aurorafinechemicals.com/info?ID=A17.894.822
Aurora Fine Chemicals LLC	A17.902.524	http://online.aurorafinechemicals.com/info?ID=A17.902.524
BioSynth	J-018587	https://www.biosynth.com/en/products/all-products/products/J-018587.html
BioSynth	J-018588	https://www.biosynth.com/en/products/all-products/products/J-018588.html
BioSynth	J-018589	https://www.biosynth.com/en/products/all-products/products/J-018589.html
BOC Sciences	104215-85-2	https://isotope.bocsci.com/product/gamma-hch-13c6-cas-104215-85-2-197523.html
BOC Sciences	119911-69-2	https://www.bocsci.com/hch-cas-119911-69-2-item-205607.html
BOC Sciences	1537222	https://www.bocsci.com/epsilon-hch-cas-6108-10-7-item-29924.html
BOC Sciences	86194-41-4	https://www.bocsci.com/hch-d6-cas-86194-41-4-item-36449.html
Chem Scene	CS-4294	http://www.chemscene.com/58-89-9.html
ChemMol	30101546	http://www.chemmol.com/chemmol/30101546.html
ChemMol	49416412	http://www.chemmol.com/chemmol/49416412.html
ChemMol	99115238	http://www.chemmol.com/chemmol/99115238.html
Chemspace	CSSB00015866333	https://chem-space.com/CSSB00015866333
Clearsynth	CS-EJ-00009	https://www.clearsynth.com/en/CSEJ00009.html
Clearsynth	CS-T-55552	https://www.clearsynth.com/en/CST55552.html
Clearsynth	CS-T-57242	https://www.clearsynth.com/en/CST57242.html
DC Chemicals	DC31727	http://www.dcchemicals.com//product_show-Lindane.html
Finetech	FT-0603490	http://www.finetechnology-ind.com/prod/detail/pub/608-73-1.html
Finetech	FT-0606175	http://www.finetechnology-ind.com/prod/detail/pub/58-89-9.html
Finetech	FT-0647466	http://www.finetechnology-ind.com/prod/detail/pub/319-84-6.html
Glentham Life Sciences	GL2031	http://www.glentham.com/products/product/GL2031/
iChemical	EBD3325828	http://www.ichemical.com/products/319-84-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
iChemical	EBD3325829	http://www.ichemical.com/products/319-86-8.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
iChemical	EBD3326092	http://www.ichemical.com/products/58-89-9.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
iChemical	EBD70494	http://www.ichemical.com/products/319-85-7.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN01292430	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01292430
LGC Standards	DRE-A14071000TO-1000	https://www.lgcstandards.com/US/en/p/DRE-A14071000TO-1000
LGC Standards	DRE-A14072000TO-1000	https://www.lgcstandards.com/US/en/p/DRE-A14072000TO-1000
LGC Standards	DRE-A14073000TO-1000	https://www.lgcstandards.com/US/en/p/DRE-A14073000TO-1000
LGC Standards	DRE-A14074000TO-1000	https://www.lgcstandards.com/US/en/p/DRE-A14074000TO-1000
LGC Standards	DRE-C14070000	https://www.lgcstandards.com/US/en/p/DRE-C14070000
MedChem Express	HY-A0085	http://www.medchemexpress.com/Lindane.html
MuseChem	I004205	https://www.musechem.com/product/I004205.html
MuseChem	M004028	https://www.musechem.com/product/M004028.html
MuseChem	M132132	https://www.musechem.com/product/M132132.html
MuseChem	R041835	https://www.musechem.com/product/R041835.html
MuseChem	R041837	https://www.musechem.com/product/R041837.html
Sigma-Aldrich	1367504_USP	https://www.sigmaaldrich.com/catalog/product/usp/1367504?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	233390_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/233390?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	300683_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/300683?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	33376_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/33376?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	33377_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/33377?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S533205	http://www.smolecule.com/products/s533205
THE BioTek	bt-273049	https://www.thebiotek.com/product/inhibitors/bt-273049
Yuhao Chemical	LL0028	http://www.chemyuhao.com/58-89-9.html
Yuhao Chemical	RT17726	http://www.chemyuhao.com/319-84-6.html
Yuhao Chemical	RT17727	http://www.chemyuhao.com/319-85-7.html
Yuhao Chemical	RT17728	http://www.chemyuhao.com/319-86-8.html

PubMed

Title	Date	PubMed
Spatial differences in persistent organochlorine pollutant concentrations between the Bering and Chukchi Seas (1993).	2001-10-17	11601531
Organochlorine compounds and aliphatic hydrocarbons in Pacific walrus blubber.	2001-10-17	11601530
Multiresidue determination of organochlorine pesticides and polychlorinated biphenyls in milk by gas chromatography with electron-capture detection after extraction by matrix solid-phase dispersion.	2001-10-17	11601477
Sperm quality and reproductive traits in male offspring of female rabbits exposed to lindane (gamma-HCH) during pregnancy and lactation.	2001-10-11	11592719
MCPA permeation through protective gloves.	2001-10	11599545
Disposition and depuration of lindane (gamma-HCH) and polychlorinated biphenyl-110 (2,3,3'4'6-pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures.	2001-10	11596773
Gridded usage inventories of technical hexachlorocyclohexane and lindane for China with 1/6 degrees latitude by 1/4 degrees longitude resolution.	2001-10	11503061
Persistent organic pollutants in agricultural soils of central Germany.	2001-09-28	11589399
Retrovirus-mediated transfer and expression of beta-hexosaminidase alpha-chain cDNA in human fibroblasts from G(M2)-gangliosidosis B1 variant.	2001-09-20	11560770
Comparison of an individual congener standard and a technical mixture for the quantification of toxaphene in environmental matrices by HRGC/ECNI-HRMS.	2001-09-01	11563655
Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats.	2001-09	11561191
Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells.	2001-09	11532877
Stimulation of DNA synthesis and c-fos mRNA expression in primary rat hepatocytes by estrogens.	2001-09	11532870
Early childhood determinants of organochlorine concentrations in school-aged children.	2001-09	11518819
Determination of organochlorine pesticides and chlorobenzenes in strawberries by using accelerated solvent extraction combined with sorptive enrichment and gas chromatography/mass spectrometry.	2001-08-15	11501923
In vitro study of the photocytotoxicity of some hypericin analogs on different cell lines.	2001-08	11547550
Deposition of semi-volatile organochlorine compounds in the free troposphere of the eastern North Atlantic Ocean.	2001-08	11525280
Seasonal dependence of the chiral composition of alpha-HCH in coastal deposition at the North Sea.	2001-08	11482646
Anthropogenic and natural organohalogen compounds in blubber of dolphins and dugongs (Dugong dugon) from northeastern Australia.	2001-08	11462147
Organochlorine pollutants in remote mountain lake waters.	2001-07-31	11476507
[Genotoxic effect of the insecticides pentachlorophenol and lindane on human nasal mucosal epithelium].	2001-07-27	11512281
GABA receptor subunit composition relative to insecticide potency and selectivity.	2001-07-06	11489356
Levels of certain metals, organochlorine pesticides and dioxins in cord blood, maternal blood, human milk and some commonly used nutrients in the surroundings of the Aral Sea (Karakalpakstan, Republic of Uzbekistan).	2001-07	11519985
Isolation and characterization of Desulfitobacterium sp. strain Y51 capable of efficient dehalogenation of tetrachloroethene and polychloroethanes.	2001-07	11515528
Persistent organochlorine pesticides detected in blood and tissue samples of vultures from different localities in South Africa.	2001-07	11461840
Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers.	2001-07	11453673
Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum.	2001-07	11445244
Monitoring of organochlorine pesticide residues in the Indian marine environment.	2001-07	11444313
Organochlorine pesticides, polychlorinated biphenyls, and butyltin compounds in blubber and livers of stranded California sea lions, elephant seals, and harbor seals from coastal California, USA.	2001-07	11385594
Atmospheric movements of lindane (gamma-hexachlorocyclohexane) from canola fields planted with treated seed.	2001-06-13	11401266
[Home transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-hexachlorocyclohexane?].	2001-06	11467223
Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats.	2001-06	11404799
Effects of nutrient loading and planktivory on the accumulation of organochlorine pesticides in aquatic food chains.	2001-06	11392141
Dioxin exposure and public health in Chapaevsk, Russia.	2001-05-25	11372889
Organochlorine pesticide residues in archived UK soil.	2001-05-15	11393978
Hexachlorocyclohexane (HCH) isomers and chiral signatures of alpha-HCH in the Arctic marine food web of the Northwater Polynya.	2001-05-15	11393969
A facile and effective synthesis of alpha-(1-->6)-linked mannose di-, tri-, tetra-, hexa-, octa-, and dodecasaccharides, and beta-(1-->6)-linked glucose di-, tri-, tetra-, hexa-, and octasaccharides using sugar trichloroacetimidates as the donors and unprotected or partially protected glycosides as the acceptors.	2001-05-08	11403082
Continuous surveillance of organochlorine compounds in human breast milk from 1972 to 1998 in Osaka, Japan.	2001-05	11525502
Dietary diversification/modification strategies to enhance micronutrient content and bioavailability of diets in developing countries.	2001-05	11509105
PCBs and organochlorine pesticide residues in eggs of Audouin's gull (Larus audouinii) in the north-eastern Mediterranean.	2001-05	11436818
Organochlorine pesticides and PCBs in a southern Atlantic coastal lagoon watershed, Argentina.	2001-04	11443366
[Organochlorine residues in eggs of night heron breeding in Yuantouzhu, Wuxi and their functions as bioindicator].	2001-03	11432055
Contamination by persistent organochlorines and butyltin compounds in the west coast of Sri Lanka.	2001-03	11381872
Accumulation status of persistent organochlorines in albatrosses from the North Pacific and the Southern Ocean.	2001	11584637
PCB biodegradation in aged contaminated soil: interactions between exogenous Phanerochaete chrysosporium and indigenous microorganisms.	2001	11545344
Distribution of organochlorine pesticides in sediments from Kyeonggi Bay and nearby areas, Korea.	2001	11504343
[Organochlorine insecticides of women's milk in Olsztyn in 1976, 1986, 1996].	2001	11452744
Contaminant residues in seabird eggs from the Canadian Arctic. Part I. Temporal trends 1975-1998.	2001	11444005
Polychlorinated biphenyl congeners and organochlorine insecticides in the water column and sediments of Daya Bay, China.	2001	11428145
Biomagnification of organochlorines along a Barents Sea food chain.	2001	11383336

Patents

Sample Use Guides

In Vivo Use Guide

Administration of shampoo for treatment of lice infestation: Most patients will require only 1 ounce of Lindane Shampoo. Based on the length and density of hair, some patients may require 2 ounces of Lindane Shampoo. Apply shampoo directly to dry hair without adding water. Work thoroughly into the hair and allow to remain in place for 4 minutes only. Special attention should be given to the fine hairs along the neck. After 4 minutes, add small quantities of water to hair until a good lather forms. Immediately rinse all lather away. Avoid unnecessary contact of lather with other body surfaces. Administration of lotion for treatment of scabies: Apply a thin layer of Lindane Lotion over all skin from the neck down. One ounce is sufficient for an average adult. Do not prescribe more than 2 ounces for larger adults. Apply only once. Wash off in 8 to 12 hours.

Route of Administration: Topical

In Vitro Use Guide

[35S]TBPS (t-butylbicyclophosphorothionate) binding was determined in a final volume of 1 ml consisting of 0.3-0.5 ml of tissue suspension (0.3--0.7 mg of protein), 0.1 ml of [35S]TBPS to give a final assay concentration of 2 nM, 0.1 ml of 2 M NaCI, and drug solutions or buffer to 1 ml. Incubations at 25°C were initiated by addition of tissue and lasted 90 min (nonwashed (NW) membranes) or 240 min (washed (W) and extensively washed (EW) membrane preparations). NW membranes were assayed in absence (NW) or presence (NW + B) of 10 uM bicuculline. Bicuculline, a GABA competitive antagonist, is used to block the inhibition of [35S]TBPS binding induced by endogenous GABA. Incubations were terminated by rapid filtration through glass-fiber filter strips, which were rinsed with three 4-ml portions of ice-cold Tris-citrate buffer using a Brandel M24 filtering manifold. Filter-bound radioactivity was quantitated by conventional liquid scintillation techniques. Lindane (0.01-100uM) and bicuculline were added in 10 uL dimethylsulfoxide. IC50 values for lindane inhibition of [35S]TBPS binding obtained for the seven brain areas ranged from 150 to 1675 nM, being smaller as the membrane preparation was more washed.

Name

Type

Language

Gamma-HCH [ISO]

Preferred Name

English

LINDANE

Official Name

English

Lindane [WHO-DD]

Common Name

English

LINDANE [USAN]

Common Name

English

BENZENE HEXACHLORIDE GAMMA

Common Name

English

LINDANE [MI]

Common Name

English

LINDANUM [WHO-IP LATIN]

Common Name

English

NSC-755895

Code

English

KWELL

Brand Name

English

GAMMAHEXACHLORCYCLOHEXANE [WHO-IP]

Common Name

English

LINDANE [WHO-IP]

Common Name

English

LINDANE [USP MONOGRAPH]

Common Name

English

?-1,2,3,4,5,6-Hexachlorocyclohexane

Common Name

English

SCABENE

Brand Name

English

LINDANE [ORANGE BOOK]

Common Name

English

1.ALPHA.,2.ALPHA.,3.BETA.,4.ALPHA.,5.ALPHA.,6.BETA.-HEXACHLOROCYCLOHEXANE

Common Name

English

?-HCH

Common Name

English

LINDANE [HSDB]

Common Name

English

LINDANE [IARC]

Common Name

English

CYCLOHEXANE, 1,2,3,4,5,6-HEXACHLORO-, (1.ALPHA.,2.ALPHA.,3.BETA.,4.ALPHA.,5.ALPHA.,6.BETA.)-

Common Name

English

(1.ALPHA.,2.ALPHA.,3.BETA.,4.ALPHA.,5.ALPHA.,6.BETA.)-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE

Common Name

English

GAMENE

Brand Name

English

lindane [INN]

Common Name

English

GAMMA BENZENE HEXACHLORIDE [WHO-IP]

Common Name

English

LINDANE [USP-RS]

Common Name

English

(1R,2R,3S,4R,5R,6S)-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE

Common Name

English

LINDANE [USP IMPURITY]

Common Name

English

LINDANE [MART.]

Common Name

English

BENZENE HEXACHLORIDE, GAMMA

Common Name

English

Classification Tree Code System Code

WHO-VATC

QP53AB52