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Details

Stereochemistry ACHIRAL
Molecular Formula C20H25NO3
Molecular Weight 327.4182
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENACTYZINE

SMILES

CCN(CC)CCOC(=O)C(c1ccccc1)(c2ccccc2)O

InChI

InChIKey=IVQOFBKHQCTVQV-UHFFFAOYSA-N
InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3

HIDE SMILES / InChI
Benactyzine, an anticholinergic drug, had been used as an antidepressant in the treatment of depression and associated anxiety. It is no longer used in medicine due to its ineffectiveness but is widely used in scientific research. Benactyzine is a muscarinic antagonist which also inhibits the nicotinic acetylcholine receptor.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Nicotinic acetylcholine receptor
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Deprol

Approved Use

treatment of depression
Primary
Anxiolit plus

Approved Use

Anxiety states of tension and excitement change of symptoms discomfort of the gastrointestinal tract, the cardiovascular system and the urinary tract due to psychological causes (psychovegetative complaints)
Doses

Doses

DosePopulationAdverse events​
1300 mg single, oral
Overdose
Dose: 1300 mg
Route: oral
Route: single
Dose: 1300 mg
Sources: Page: p.86
unknown
n = 1
Health Status: unknown
Population Size: 1
Sources: Page: p.86
Disc. AE: Psychosis...
AEs leading to
discontinuation/dose reduction:
Psychosis
Sources: Page: p.86
200 mg single, oral
Overdose
Dose: 200 mg
Route: oral
Route: single
Dose: 200 mg
Sources: Page: p.86
healthy
n = 1
Health Status: healthy
Population Size: 1
Sources: Page: p.86
Disc. AE: Delirium...
AEs leading to
discontinuation/dose reduction:
Delirium (severe)
Sources: Page: p.86
AEs

AEs

AESignificanceDosePopulation
Psychosis Disc. AE
1300 mg single, oral
Overdose
Dose: 1300 mg
Route: oral
Route: single
Dose: 1300 mg
Sources: Page: p.86
unknown
n = 1
Health Status: unknown
Population Size: 1
Sources: Page: p.86
Delirium severe
Disc. AE
200 mg single, oral
Overdose
Dose: 200 mg
Route: oral
Route: single
Dose: 200 mg
Sources: Page: p.86
healthy
n = 1
Health Status: healthy
Population Size: 1
Sources: Page: p.86
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes
PubMed

PubMed

TitleDatePubMed
Meprobamate-benactyzine (Deprol) and placebo in two depressed outpatient populations.
1969 Mar-Apr
[Effect of several neuroleptic, adreno-, sympatho- and cholinolytic substances on the development of experimental cerebral edema induced by nicotine].
1977 May-Jun
Effects of advanced candidate anticonvulsants under two rodent models of 'counting'.
2001 Dec
[Effect of diazepam on antidote therapy of lethal toxic effects of soman in rats].
2001 Sep
Anticholinergic and antiglutamatergic agents protect against soman-induced brain damage and cognitive dysfunction.
2003 Sep
Protective effect of reversible cholinesterase inhibitors (tacrine, pyridostigmine) and eqbuche against VX poisoning and brain acetylcholinesterase inhibition in rats.
2008
The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents.
2008 Jun
Role of the cholinergic mechanisms of the ventrolateral preoptic area of the hypothalamus in regulating the state of sleep and waking in pigeons.
2008 Mar
Sexual function in adult male rats after prenatal modulation of the cholinergic system.
2009 Jun
Paraoxon attenuates vascular smooth muscle contraction through inhibiting Ca2+ influx in the rabbit thoracic aorta.
2010

Sample Use Guides

The patient is receiving benactyzine at a dose starting with 1 mg three times a day rising within five days to 2 mg four times a day, and remaining at that level until the end of the test period
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
BENACTYZINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
BENACTYZINE [WHO-DD]
Common Name English
BENACTYZINE [HSDB]
Common Name English
2-DIETHYLAMINOETHYL BENZILATE
Systematic Name English
BENACTYZINE [VANDF]
Common Name English
BENACTYZINE [MI]
Common Name English
BENACTYZINE [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
Code System Code Type Description
MESH
D001535
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
DRUG CENTRAL
298
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
INN
496
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
HSDB
3292
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
CAS
302-40-9
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
ChEMBL
CHEMBL70352
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
EPA CompTox
302-40-9
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
MERCK INDEX
M2301
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY Merck Index
EVMPD
SUB05696MIG
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
NCI_THESAURUS
C81454
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
RXCUI
1361
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
BENACTYZINE
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
DRUG BANK
DB09023
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
PUBCHEM
9330
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
ECHA (EC/EINECS)
206-123-8
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY
FDA UNII
595EG71R3F
Created by admin on Sat Jun 26 10:48:52 UTC 2021 , Edited by admin on Sat Jun 26 10:48:52 UTC 2021
PRIMARY