Details
Stereochemistry | RACEMIC |
Molecular Formula | C20H9Br2HgO5 |
Molecular Weight | 689.68 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
OC1=C(Br)C=C2C(OC3=C([Hg+])C(O)=C(Br)C=C3C24OC(=O)C5=C4C=CC=C5)=C1
InChI
InChIKey=MWYPSCPMURJPPE-UHFFFAOYSA-N
InChI=1S/C20H9Br2O5.Hg/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20;/h1-7,23-24H;/q;+1
DescriptionSources: http://ispub.com/IJS/21/2/5354Curator's Comment: description was created based on several sources, including
https://medlineplus.gov/ency/article/002897.htm
https://en.wikipedia.org/wiki/Merbromin
http://www.ncbi.nlm.nih.gov/pubmed/11766105
Sources: http://ispub.com/IJS/21/2/5354
Curator's Comment: description was created based on several sources, including
https://medlineplus.gov/ency/article/002897.htm
https://en.wikipedia.org/wiki/Merbromin
http://www.ncbi.nlm.nih.gov/pubmed/11766105
Merbromin (marketed as Mercurochrome, Merbromine) is a topical antiseptic used for minor cuts and scrapes. It is readily available in most countries but, because of its mercury content, it is no longer sold in Switzerland, France, Germany, and the United States. Merbromin's best-known use is as a topical antiseptic to treat minor wounds, burns, and scratches. It is also used in the antisepsis of the umbilical cord and the antisepsis of wound of difficult scar formation, like neuropathic ulcers, and diabetic foot sores. The U.S. Food and Drug Administration in 1998 classified merbromin as "not Generally Recognized as Safe" together with a multitude of other active compounds, based on the absence of interest on the part of pharmaceutical companies in funding new studies or updated supporting information, due to the high costs of said studies in comparison to sales, rather than due to being toxic. In the United States, its use has been superseded by other agents (e.g., povidone iodine, benzalkonium chloride, chloroxylenol). It is still an important antiseptic, particularly in developing nations, due to its “unbelievably low cost.”
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Unknown Approved UseUnknown |
|||
Sources: http://ispub.com/IJS/21/2/5354 |
Primary | Unknown Approved UseUnknown |
Doses
Dose | Population | Adverse events |
---|---|---|
2 % single, topical |
unhealthy, 4-38 n = 8 Health Status: unhealthy Condition: skin wounds Age Group: 4-38 Sex: M+F Population Size: 8 Sources: |
Other AEs: Allergy... |
2 % multiple, topical |
unhealthy, 59 n = 1 Health Status: unhealthy Condition: surgical wounds Age Group: 59 Sex: F Population Size: 1 Sources: |
Other AEs: Aplastic anemia... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Allergy | 8% | 2 % single, topical |
unhealthy, 4-38 n = 8 Health Status: unhealthy Condition: skin wounds Age Group: 4-38 Sex: M+F Population Size: 8 Sources: |
Aplastic anemia | 1% | 2 % multiple, topical |
unhealthy, 59 n = 1 Health Status: unhealthy Condition: surgical wounds Age Group: 59 Sex: F Population Size: 1 Sources: |
Sample Use Guides
In Vivo Use Guide
Sources: http://ispub.com/IJS/21/2/5354
Mercurochrome is 2% aqueous merbromin solution
Route of Administration:
Topical
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ACTIVE MOIETY