U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
BACITRACIN

Approved Use

Uses first aid to help prevent infection in: •minor cuts •scrapes •burns

Launch Date

-6.7616637E11
Curative
CORTISPORIN

Approved Use

For the treatment of corticosteroid-responsice dermatoses with secondary infection.

Launch Date

-4.0417919E11
Curative
NEOSPORIN

Approved Use

NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.

Launch Date

-4.7260799E10
PubMed

PubMed

TitleDatePubMed
Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.
1948 Feb
The relative antisyphilitic activity of penicillins F,G,K, and X and of bacitracin, based on the amounts required to abort early syphilic infections in rabbits.
1948 Mar
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.
1948 Mar
The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report.
1948 Oct
A Note on the Susceptibility of Hemophilus influenzae Type B to Bacitracin.
1948 Oct
The Use of Bacitracin in Experimental Clostridium Welchii Infection in Guinea Pigs.
1949 Oct
IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN.
1949 Sep
In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics; penicillin, streptomycin, bacitracin, polymyxin, aerosporin, aureomycin, and chloromycetin.
1950 Feb
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.
1950 Feb
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.
1992 Dec
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.
1992 Jul 15
[Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos].
2001 Nov
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.
2002 Aug
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.
2002 Aug
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
2002 Dec 13
S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
2002 Jul 2
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
2002 Nov
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3.
2002 Sep 11
Induction of metallothionein by zinc protects from daunorubicin toxicity in rats.
2002 Sep 30
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.
2003 Apr
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.
2003 Apr
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.
2003 Apr
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.
2003 Aug
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.
2003 Aug 1
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
2003 Aug 15
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.
2003 Aug 19
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.
2003 Aug 29
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
2003 Dec 5
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.
2003 Feb 15
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.
2003 Jan
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.
2003 Jan 1
A novel class of ligand-gated ion channel is activated by Zn2+.
2003 Jan 10
Differential effects of zinc on functionally distinct human growth hormone mutations.
2003 Jul
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.
2003 Jul 11
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.
2003 Jun
Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein.
2003 Jun
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
2003 Mar
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.
2003 May 2
Zinc modulates mRNA levels of cytokines.
2003 Nov
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.
2003 Nov 14
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.
2003 Oct
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
2003 Oct 1
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.
2003 Oct 3
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
2003 Oct 3
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.
2003 Sep
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
2003 Sep 23
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
2004 Apr
Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants.
2004 Mar
Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.
2016 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration: Topical
The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.
Name Type Language
BACITRACIN
EP   HSDB   INN   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
TOPITRACIN
Common Name English
NSC-755905
Code English
LANABIOTIC COMPONENT BACITRACIN
Common Name English
BACITRACIN [WHO-IP]
Common Name English
PENITRACIN
Common Name English
BACITRACIN [EP MONOGRAPH]
Common Name English
MYCITRACIN COMPONENT BACITRACIN
Common Name English
FORTRACIN
Common Name English
BACITRACIN [VANDF]
Common Name English
BACIIM
Brand Name English
BACITRACIN [USP]
Common Name English
PARENTRACIN
Common Name English
BACITRACIN [USP MONOGRAPH]
Common Name English
BACIGUENT
Brand Name English
BACI-RX
Brand Name English
BACITRACIN [ORANGE BOOK]
Common Name English
BACILLIQUIN
Common Name English
BACITRACIN [WHO-DD]
Common Name English
BACITRACIN [HSDB]
Common Name English
BACITRACINUM [WHO-IP LATIN]
Common Name English
BACITRACIN COMPONENT OF MYCITRACIN
Common Name English
ZUTRACIN
Common Name English
BACITRACIN COMPONENT OF LANABIOTIC
Common Name English
TROPITRACIN
Common Name English
BACITRACIN [INN]
Common Name English
BACITRACIN(NON-INJECTABLE) [WHO-IP]
Common Name English
BACITRACIN [MI]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 1284
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-VATC QR02AB04
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-ATC J01XX10
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 333.120
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 524.155
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-ATC R02AB04
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 556.70
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
EPA PESTICIDE CODE 6302
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 333.110
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 524.154
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
CFR 21 CFR 520.154
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-ATC D06AX05
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-VATC QJ01XX10
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-VATC QD06AX05
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
WHO-VATC QA07AA93
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
Code System Code Type Description
WIKIPEDIA
BACITRACIN
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
ECHA (EC/EINECS)
215-786-2
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
EVMPD
SUB00652MIG
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
RXCUI
1291
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY RxNorm
WHO INTERNATIONAL PHARMACOPEIA
BACITRACIN
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY Description: A white or pale brownish yellow powder; odourless or with a faint characteristic odour. Solubility: Freely soluble in water, methanol R and ethanol (~750 g/l) TS; practically insoluble in acetone R and ether R. Category: Antiinfective drug. Storage: Bacitracin should be kept in a tightly closed container, protected from light and stored at a temperature between 2? and8?C. If it is intended for parenteral administration, the container should be sterile and sealed so as to exclude micro-organisms. Labelling: The designation sterile Bacitracin indicates that the substance complies with the additional requirements for sterileBacitracin and may be used for parenteral administration or for other sterile applications. Additional information: Bacitracin is hygroscopic. Its solutions deteriorate rapidly at room temperature. Even in the absence oflight, it is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures.
DRUG BANK
DB00626
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
FDA UNII
58H6RWO52I
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
NCI_THESAURUS
C295
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
INN
1167
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
MERCK INDEX
M2197
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY Merck Index
NDF-RT
N0000008479
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY Decreased Cell Wall Synthesis & Repair [PE]
LACTMED
Bacitracin
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
MESH
D001414
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
CAS
1405-87-4
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
ChEMBL
CHEMBL1200558
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
DRUG CENTRAL
281
Created by admin on Fri Jun 25 21:02:55 UTC 2021 , Edited by admin on Fri Jun 25 21:02:55 UTC 2021
PRIMARY
Definition References