Bacitracin

Description

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7	Binding Agent 1,064

Conditions

Condition	Modality	Highest Phase	Product
Infection 7	Curative	Approved 8,429	BACITRACIN
Skin diseases 10	Curative	Approved 8,429	CORTISPORIN
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5	Curative	Approved 8,429	NEOSPORIN

PubMed

Show entries

Title	Date	PubMed
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133
Continuous administration of growth hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding.	1998 Dec	10985758
Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death.	1999 Aug	10428039
Intestinal damage induced by zinc deficiency is associated with enhanced CuZn superoxide dismutase activity in rats: effect of dexamethasone or thyroxine treatment.	1999 May	10381190