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Description

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.
1992 Dec
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.
1992 Jul 15
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
2003 Aug 15
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
2003 Dec 5
Differential effects of zinc on functionally distinct human growth hormone mutations.
2003 Jul
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.
2003 Nov 14
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.
2003 Oct
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.
2003 Sep
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
2003 Sep 23
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
2004 Apr
Patents

Sample Use Guides

In Vivo Use Guide
400 units, topically
Route of Administration: Topical
In Vitro Use Guide
The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.
Name Type Language
BACITRACIN
EP   HSDB   INN   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
TOPITRACIN
Common Name English
LANABIOTIC COMPONENT BACITRACIN
Common Name English
BACITRACIN [WHO-IP]
Common Name English
PENITRACIN
Common Name English
MYCITRACIN COMPONENT BACITRACIN
Common Name English
FORTRACIN
Common Name English
BACITRACIN [VANDF]
Common Name English
BACIIM
Brand Name English
BACITRACIN [USP]
Common Name English
PARENTRACIN
Common Name English
BACIGUENT
Brand Name English
BACITRACIN [EP]
Common Name English
BACI-RX
Brand Name English
BACITRACIN [ORANGE BOOK]
Common Name English
BACILLIQUIN
Common Name English
BACITRACIN [WHO-DD]
Common Name English
BACITRACIN [HSDB]
Common Name English
BACITRACINUM [WHO-IP LATIN]
Common Name English
BACITRACIN COMPONENT OF MYCITRACIN
Common Name English
ZUTRACIN
Common Name English
BACITRACIN [USP-RS]
Common Name English
BACITRACIN COMPONENT OF LANABIOTIC
Common Name English
TROPITRACIN
Common Name English
BACITRACIN [JAN]
Common Name English
BACITRACIN [INN]
Common Name English
BACITRACIN(NON-INJECTABLE) [WHO-IP]
Common Name English
BACITRACIN [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QR02AB04
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-ATC J01XX10
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 333.120
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 524.155
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-ATC R02AB04
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 556.70
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
EPA PESTICIDE CODE 6302
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 333.110
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 524.154
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
CFR 21 CFR 520.154
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-ATC D06AX05
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-VATC QJ01XX10
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-VATC QD06AX05
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
WHO-VATC QA07AA93
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
Code System Code Type Description
WIKIPEDIA
BACITRACIN
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
ECHA (EC/EINECS)
215-786-2
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
EVMPD
SUB00652MIG
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
RXCUI
1291
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY RxNorm
WHO INTERNATIONAL PHARMACOPEIA
BACITRACIN
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY Description: A white or pale brownish yellow powder; odourless or with a faint characteristic odour. Solubility: Freely soluble in water, methanol R and ethanol (~750 g/l) TS; practically insoluble in acetone R and ether R. Category: Antiinfective drug. Storage: Bacitracin should be kept in a tightly closed container, protected from light and stored at a temperature between 2? and8?C. If it is intended for parenteral administration, the container should be sterile and sealed so as to exclude micro-organisms. Labelling: The designation sterile Bacitracin indicates that the substance complies with the additional requirements for sterileBacitracin and may be used for parenteral administration or for other sterile applications. Additional information: Bacitracin is hygroscopic. Its solutions deteriorate rapidly at room temperature. Even in the absence oflight, it is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures.
DRUG BANK
DB00626
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
NCI_THESAURUS
C295
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
INN
1167
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
MERCK INDEX
M2197
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY Merck Index
NDF-RT
N0000008479
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY Decreased Cell Wall Synthesis & Repair [PE]
MESH
D001414
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
CAS
1405-87-4
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
ChEMBL
CHEMBL1200558
Created by admin on Tue Mar 06 13:25:24 UTC 2018 , Edited by admin on Tue Mar 06 13:25:24 UTC 2018
PRIMARY
Definition References