BACITRACIN

US Approved OTC

First marketed in 1921

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 989

Conditions

Condition	Modality	Highest Phase	Product
Infection 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 7968	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date -6.7616637E11
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 7968	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date -4.0417919E11
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 7968	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date -4.7260799E10

PubMed

Title	Date	PubMed
Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.	1975 Jun 16	1175606
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133
Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin.	2001	11842894
cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes.	2001 Dec	11739864
[Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos].	2001 Nov	12561611
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses.	2001 Nov	11739637
Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats.	2001 Nov 1	11705462
Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency.	2001 Nov 20	11717422
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.	2002 Aug	12107073
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.	2002 Aug	12107072
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.	2002 Dec	12405537
Purification and characterization of cytosolic glycerol-3-phosphate dehydrogenase from skeletal muscle of jerboa (Jaculus orientalis).	2002 Feb	11952153
Allosteric modulation of beta2-adrenergic receptor by Zn(2+).	2002 Jan	11752207
Role of a copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin.	2002 Jan 15	11803044
S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.	2002 Jul 2	12081484
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.	2002 Jul 5	11983694
Partitioning of accumulated trace metals in the talitrid amphipod crustacean Orchestia gammarellus: a cautionary tale on the use of metallothionein-like proteins as biomarkers.	2002 Jun	11932003
Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina.	2002 Jun 30	12106692
White-sided dolphin metallothioneins: purification, characterisation and potential role.	2002 Mar	11912049
Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.	2002 May 10	11880373
Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively.	2002 May 14	11994011
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.	2002 May 24	11904301
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.	2002 Nov	12429649
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.	2002 Nov	12421840
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.	2003 Apr	12714242
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.	2003 Apr	12679171
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.	2003 Apr	12672911
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.	2003 Aug	12888634
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.	2003 Aug 1	12888280
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.	2003 Aug 29	12801924
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.	2003 Dec 5	14506276
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.	2003 Feb 15	12566098
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.	2003 Feb 4	12549918
Activation of the rainbow trout metallothionein-A promoter by silver and zinc.	2003 Jan	12524046
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.	2003 Jan	12514266
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.	2003 Jan	12514265
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.	2003 Jan 1	12517797
Differential effects of zinc on functionally distinct human growth hormone mutations.	2003 Jul	12915731
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.	2003 Jul 11	12716893
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003 Jun	12798935
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.	2003 Mar	12572668
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003 May 2	12595529
Zinc modulates mRNA levels of cytokines.	2003 Nov	12812920
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.	2003 Nov 14	12947092
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.	2003 Oct	14519784
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.	2003 Oct 3	12885774
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.	2003 Sep	12963354
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.	2003 Sep 23	12974631
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.	2004 Apr	12972402

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Name

Type

Language

BACITRACIN

Official Name

English

TOPITRACIN

Common Name

English

NSC-755905

Code

English

LANABIOTIC COMPONENT BACITRACIN

Common Name

English

BACITRACIN [WHO-IP]

Common Name

English

PENITRACIN

Common Name

English

BACITRACIN [EP MONOGRAPH]

Common Name

English

MYCITRACIN COMPONENT BACITRACIN

Common Name

English

FORTRACIN

Common Name

English

BACITRACIN [VANDF]

Common Name

English

BACIIM

Brand Name

English

BACITRACIN [USP]

Common Name

English

PARENTRACIN

Common Name

English

BACITRACIN [USP MONOGRAPH]

Common Name

English

BACIGUENT

Brand Name

English

BACI-RX

Brand Name

English

BACITRACIN [ORANGE BOOK]

Common Name

English

BACILLIQUIN

Common Name

English

BACITRACIN [WHO-DD]

Common Name

English

BACITRACIN [HSDB]

Common Name

English

BACITRACINUM [WHO-IP LATIN]

Common Name

English

BACITRACIN COMPONENT OF MYCITRACIN

Common Name

English

ZUTRACIN

Common Name

English

BACITRACIN COMPONENT OF LANABIOTIC

Common Name

English

TROPITRACIN

Common Name

English

BACITRACIN [INN]

Common Name

English

BACITRACIN(NON-INJECTABLE) [WHO-IP]

Common Name

English

BACITRACIN [MI]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

1284