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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H16O3
Molecular Weight 244.2857
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NAPROXEN METHYL ESTER

SMILES

COC(=O)[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1

InChI

InChIKey=ZFYFBPCRUQZGJE-JTQLQIEISA-N
InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1

HIDE SMILES / InChI
Naproxen methyl ester, a mixture of two isomers R and S, is the precursor of therapeutically important nonsteroidal anti-inflammatory drug naproxen. Naproxen methyl ester can be enantioselectively hydrolyzed by lipases or (S)-enantioselective esterase could catalyze the selective hydrolysis of the (S)-Naproxen methyl ester, giving optically pure (S)-naproxen. In addition, S-naproxen methyl ester is used as a tool for identification and determination of new stereo selective carboxylesterase activities.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: esterase Sso-Est1 from S. solfataricus P1
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
NAPROXEN METHYL ESTER
Common Name English
2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, METHYL ESTER, (.ALPHA.S)-
Systematic Name English
NAPROXEN IMPURITY E [EP IMPURITY]
Common Name English
(+)-NAPROXEN METHYL ESTER
Common Name English
NAPROXEN SODIUM IMPURITY E [EP IMPURITY]
Common Name English
(S)-NAPROXEN METHYL ESTER
Common Name English
METHYL (2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE
Systematic Name English
Code System Code Type Description
FDA UNII
571OJX4PDN
Created by admin on Sat Dec 16 08:34:57 GMT 2023 , Edited by admin on Sat Dec 16 08:34:57 GMT 2023
PRIMARY
PUBCHEM
9899603
Created by admin on Sat Dec 16 08:34:57 GMT 2023 , Edited by admin on Sat Dec 16 08:34:57 GMT 2023
PRIMARY
EPA CompTox
DTXSID50180780
Created by admin on Sat Dec 16 08:34:57 GMT 2023 , Edited by admin on Sat Dec 16 08:34:57 GMT 2023
PRIMARY
CAS
26159-35-3
Created by admin on Sat Dec 16 08:34:57 GMT 2023 , Edited by admin on Sat Dec 16 08:34:57 GMT 2023
PRIMARY