ALTOQUALINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H36N2O8
Molecular Weight	516.5833
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=C2[C@H](OC(=O)C2=C(N)C(OCC)=C1OCC)[C@@H]3N(C)CCC4=CC(OC)=C(OC)C(OC)=C34

InChI

InChIKey=FPSZSEINEGCRIJ-IRLDBZIGSA-N

InChI=1S/C27H36N2O8/c1-8-34-24-18-17(19(28)25(35-9-2)26(24)36-10-3)27(30)37-22(18)20-16-14(11-12-29(20)4)13-15(31-5)21(32-6)23(16)33-7/h13,20,22H,8-12,28H2,1-7H3/t20-,22+/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7195643 | https://www.ncbi.nlm.nih.gov/pubmed/1971461

Altoqualine (458L) is a derivative of benzylisoquinoline, it inhibited kidney histidine decarboxylase and decreased the passive anaphylactic bronchospasm in guinea pigs. Altoqualine is an antihistamine and antiallergic agent.

Approval Year

PubMed

Title	Date	PubMed
[Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men].	1990-01-01	1971461
Pharmacological approach of a new isoquinoline derivative (458 L).	1981-04	7195643

Patents

Sample Use Guides

In Vivo Use Guide

Guinea pigs: the 458L compound was given once in gelatin capsules, by oral route, 5 h before sacrifice in groups of 6 animals. The dose used was from 10 to 120 mg/kg.

Route of Administration: Oral

Name

Type

Language

altoqualine [INN]

Preferred Name

English

ALTOQUALINE

Official Name

English

(3S)-7-AMINO-4,5,6-TRIETHOXY-3-((1R)-1,2,3,4-TETRAHYDRO-6,7,8-TRIMETHOXY-2-METHYL-1-ISOQUINOLYL)PHTHALIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578