ALTOQUALINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H36N2O8
Molecular Weight	516.5833
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(OC(=O)C2=C1C(OCC)=C(OCC)C(OCC)=C2N)[C@]3([H])N(C)CCC4=C3C(OC)=C(OC)C(OC)=C4

InChI

InChIKey=FPSZSEINEGCRIJ-IRLDBZIGSA-N

InChI=1S/C27H36N2O8/c1-8-34-24-18-17(19(28)25(35-9-2)26(24)36-10-3)27(30)37-22(18)20-16-14(11-12-29(20)4)13-15(31-5)21(32-6)23(16)33-7/h13,20,22H,8-12,28H2,1-7H3/t20-,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C27H36N2O8
Molecular Weight	516.5833
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7195643 | https://www.ncbi.nlm.nih.gov/pubmed/1971461

Altoqualine (458L) is a derivative of benzylisoquinoline, it inhibited kidney histidine decarboxylase and decreased the passive anaphylactic bronchospasm in guinea pigs. Altoqualine is an antihistamine and antiallergic agent.

Approval Year

PubMed

Title	Date	PubMed
Pharmacological approach of a new isoquinoline derivative (458 L).	1981 Apr	7195643
[Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men].	1990 Jan-Feb	1971461

Patents

Sample Use Guides

In Vivo Use Guide

Guinea pigs: the 458L compound was given once in gelatin capsules, by oral route, 5 h before sacrifice in groups of 6 animals. The dose used was from 10 to 120 mg/kg.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:06 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:06 GMT 2023`
Record UNII	56G228IW9Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALTOQUALINE

Official Name

English

(3S)-7-AMINO-4,5,6-TRIETHOXY-3-((1R)-1,2,3,4-TETRAHYDRO-6,7,8-TRIMETHOXY-2-METHYL-1-ISOQUINOLYL)PHTHALIDE

Systematic Name

English

altoqualine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578