OZOLINONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H16N2O3S
Molecular Weight	256.321
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)C(S\C1=C/C(O)=O)N2CCCCC2

InChI

InChIKey=NQFBZYYUAFJYNS-FPLPWBNLSA-N

InChI=1S/C11H16N2O3S/c1-12-8(7-9(14)15)17-11(10(12)16)13-5-3-2-4-6-13/h7,11H,2-6H2,1H3,(H,14,15)/b8-7-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/714186 | https://www.ncbi.nlm.nih.gov/pubmed/7675125

Ozolinone, an active metabolite of diuretic etozoline was studied also as a loop diuretic. Experiments on dogs have shown that ozolinone, induced stereoselective and prostaglandin-dependent renin secretion, which was involved in the regulation of intra-renal hemodynamics. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function. I. Clearance studies in dogs.	1978 Oct	714186
Quantitative evaluation of ototoxic side effects of furosemide, piretanide, bumetanide, azosemide and ozolinone in the cat--a new approach to the problem of ototoxicity.	1985 Nov	4088324

Name

Type

Language

OZOLINONE

Official Name

English

(2Z)-2-(3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)ACETIC ACID

Common Name

English

ACETIC ACID, 2-(3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, (2Z)-

Systematic Name

English

ozolinone [INN]

Common Name

English

ACETIC ACID, (3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, (Z)-

Common Name

English

(±)-OZOLINONE

Common Name

English

OZOLINONE [USAN]

Common Name

English

GOEDECKE-382

Code

English

GOEDECKE 382

Code

English

(Z)-3-METHYL-4-OXO-5-PIPERIDINO-.DELTA.(SUP 2,.ALPHA.)-THIAZOLIDINEACETIC ACID.

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C49184