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Details

Stereochemistry ACHIRAL
Molecular Formula C32H34ClN7O2
Molecular Weight 584.111
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CB-300919

SMILES

CN1CCN(CC2=NC3=C(C=C(CN(CC#C)C4=CC=C(C=C4)C(=O)NCC5=CC=CN=C5)C(Cl)=C3)C(=O)N2C)CC1

InChI

InChIKey=LWTCFUSGPRGUBX-UHFFFAOYSA-N
InChI=1S/C32H34ClN7O2/c1-4-12-40(26-9-7-24(8-10-26)31(41)35-20-23-6-5-11-34-19-23)21-25-17-27-29(18-28(25)33)36-30(38(3)32(27)42)22-39-15-13-37(2)14-16-39/h1,5-11,17-19H,12-16,20-22H2,2-3H3,(H,35,41)

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/12166942| DOI: http://dx.doi.org/10.1016/S0959-8049(02)80688-8

CB 300919 is a water-soluble analogue of CB30865. Preclinical data revealed that CB 300919 was a potential therapy for ovarian cancer, what was shown for tumor xenograft mice. CB 300919 is an inhibitor of Nicotinamide phosphoribosyltransferase.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.23 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent.
2002 Aug 15
Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).
2010 Dec 23
Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound.
2010 Jun 25
Patents

Sample Use Guides

model mice: single dose: 10 mg/kg/
Route of Administration: Intraperitoneal
CB-300919 (MPI-0479626) is a potent cytotoxic compound, with an average TC50 of 0.7 nM in HCT116 (human colon carcinoma) cells.
Name Type Language
CB-300919
Common Name English
BENZAMIDE, 4-(((7-CHLORO-3,4-DIHYDRO-3-METHYL-2-((4-METHYL-1-PIPERAZINYL)METHYL)-4-OXO-6-QUINAZOLINYL)METHYL)-2-PROPYNYLAMINO)-N-(3-PYRIDINYLMETHYL)-
Systematic Name English
BENZAMIDE, 4-(((7-CHLORO-3,4-DIHYDRO-3-METHYL-2-((4-METHYL-1-PIPERAZINYL)METHYL)-4-OXO-6-QUINAZOLINYL)METHYL)-2-PROPYN-1-YLAMINO)-N-(3-PYRIDINYLMETHYL)-
Systematic Name English
Code System Code Type Description
FDA UNII
55I8ETE76Y
Created by admin on Sat Dec 16 11:08:24 GMT 2023 , Edited by admin on Sat Dec 16 11:08:24 GMT 2023
PRIMARY
PUBCHEM
9938280
Created by admin on Sat Dec 16 11:08:24 GMT 2023 , Edited by admin on Sat Dec 16 11:08:24 GMT 2023
PRIMARY
EPA CompTox
DTXSID90183174
Created by admin on Sat Dec 16 11:08:24 GMT 2023 , Edited by admin on Sat Dec 16 11:08:24 GMT 2023
PRIMARY
CAS
289715-28-2
Created by admin on Sat Dec 16 11:08:24 GMT 2023 , Edited by admin on Sat Dec 16 11:08:24 GMT 2023
PRIMARY