Details
Stereochemistry | ACHIRAL |
Molecular Formula | F6Si.2H |
Molecular Weight | 144.0918 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].F[Si--](F)(F)(F)(F)F
InChI
InChIKey=OHORFAFFMDIQRR-UHFFFAOYSA-P
InChI=1S/F6Si/c1-7(2,3,4,5)6/q-2/p+2
Ammonium hexafluorosilicate is a white crystalline solid. Corrodes aluminum. Used as a disinfectant, in etching glass, metal casting, and electroplating. Ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity, since ammonium hexafluorosilicate induced calcium phosphate precipitation from the saliva; therefore, it has a continuous effect on dentin tubules occlusion under a simulated oral environment. Ammonium hexafluorosilicate has been applied to arrest caries without discoloration. The major use of sodium hexafluorosilicate and fluorosilicic acid is as fluoridation agents for drinking water. Sodium hexafluorosilicate has also been used for caries control as part of asilicophosphate cement, an acidic gel in combination with monocalcium phosphate monohydrate,and a two-solution fluoride mouth rinse. Both chemicals are also used as a chemical intermediate (raw material) for aluminum trifluoride, cryolite (Na3AlF6), silicon tetrafluoride,and other fluorosilicates and have found applications in commercial laundry. Other applications for sodium hexafluorosilicate include its use in enamels/enamel frits for china and porcelain, in opalescent glass, metallurgy (aluminum and beryllium), glue, ore flotation, leather and wood preservatives, and in insecticides and rodenticides. It has been used in the manufacture of pure silicon, as a gelling agent in the production of molded latex foam, and as afluorinating agent in organic synthesis to convert organodichlorophosphorus compounds to the corresponding organodifluorophosphorus compound. In veterinary practice, external applicationof sodium hexafluorosilicate combats lice and mosquitoes on cattle, sheep, swine, and poultry, and oral administration combats roundworms and possibly whipworms in swine and prevents dental caries in rats. Apparently, all pesticidal products had their registrations cancelled or they were discontinued by the early 1990s
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: In mice, an oral LD50 of 70 mg/kg (0.37 mmol/kg) for sodium hexafluorosilicate was reported. In rats, oral LD50 values of 125 and 430 mg/kg (0.665 and 2.29 mmol/kg, respectively) were calculated.
A probable oral lethal dose of 50-5000 mg/kg, classified as very toxic, has been reported for doses between 1 teaspoon and 1 ounce for a 150-pound (70-kg) person; a probable oral lethal dose of 5-50 mg/kg, classified as extremely toxic, has been reported for doses between 7 drops and 1 teaspoon for the same individual.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24055547
The purpose of the study was to investigate the cytotoxicity of Ammonium hexafluorosilicate (SiF) on human gingival fibroblasts (hGFs) under different dosages (0.001%, 0.01%, 0.1%, and 1%) and treatment durations (1, 5, 10, and 30 min). MTT assay showed that there was significantly lower number of viable cells when the hGFs were treated with 0.01% (10min), 0.1% (10 and 30 min) and 1% (5, 10, and 30min) SiF than the control group (p<0.05). MMP decreased and GSH depletion increased dramatically along with higher concentrations (0.1% and 1% SiF) and prolonged times (10 and 30 min). DNA synthesis [S (%)] of cells treated with 0.1% and 1% SiF (5, 10, and 30min) was significantly lower than the control group (p<0.05). So exposure to up to 0.01% SiF for less than 5min causes low or no cytotoxicity in vitro.
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EPA PESTICIDE CODE |
75305
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16894
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21863527
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241-034-8
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2018
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DTXSID2029741
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16961-83-4
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300000013921
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1431152
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m5484
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53V4OQG6U1
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HEXAFLUOROSILICIC ACID
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C035291
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SUBSTANCE RECORD