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Details

Stereochemistry ACHIRAL
Molecular Formula F6Si.2H
Molecular Weight 144.0918
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUOSILICIC ACID

SMILES

[H+].[H+].F[Si--](F)(F)(F)(F)F

InChI

InChIKey=OHORFAFFMDIQRR-UHFFFAOYSA-P
InChI=1S/F6Si/c1-7(2,3,4,5)6/q-2/p+2

HIDE SMILES / InChI

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula F6Si
Molecular Weight 142.0759
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium hexafluorosilicate is a white crystalline solid. Corrodes aluminum. Used as a disinfectant, in etching glass, metal casting, and electroplating. Ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity, since ammonium hexafluorosilicate induced calcium phosphate precipitation from the saliva; therefore, it has a continuous effect on dentin tubules occlusion under a simulated oral environment. Ammonium hexafluorosilicate has been applied to arrest caries without discoloration. The major use of sodium hexafluorosilicate and fluorosilicic acid is as fluoridation agents for drinking water. Sodium hexafluorosilicate has also been used for caries control as part of asilicophosphate cement, an acidic gel in combination with monocalcium phosphate monohydrate,and a two-solution fluoride mouth rinse. Both chemicals are also used as a chemical intermediate (raw material) for aluminum trifluoride, cryolite (Na3AlF6), silicon tetrafluoride,and other fluorosilicates and have found applications in commercial laundry. Other applications for sodium hexafluorosilicate include its use in enamels/enamel frits for china and porcelain, in opalescent glass, metallurgy (aluminum and beryllium), glue, ore flotation, leather and wood preservatives, and in insecticides and rodenticides. It has been used in the manufacture of pure silicon, as a gelling agent in the production of molded latex foam, and as afluorinating agent in organic synthesis to convert organodichlorophosphorus compounds to the corresponding organodifluorophosphorus compound. In veterinary practice, external applicationof sodium hexafluorosilicate combats lice and mosquitoes on cattle, sheep, swine, and poultry, and oral administration combats roundworms and possibly whipworms in swine and prevents dental caries in rats. Apparently, all pesticidal products had their registrations cancelled or they were discontinued by the early 1990s

Approval Year

PubMed

PubMed

TitleDatePubMed
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion.
2008 Feb
Cytotoxicity of ammonium hexafluorosilicate on human gingival fibroblasts.
2013 Dec
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: In mice, an oral LD50 of 70 mg/kg (0.37 mmol/kg) for sodium hexafluorosilicate was reported. In rats, oral LD50 values of 125 and 430 mg/kg (0.665 and 2.29 mmol/kg, respectively) were calculated.
A probable oral lethal dose of 50-5000 mg/kg, classified as very toxic, has been reported for doses between 1 teaspoon and 1 ounce for a 150-pound (70-kg) person; a probable oral lethal dose of 5-50 mg/kg, classified as extremely toxic, has been reported for doses between 7 drops and 1 teaspoon for the same individual.
Route of Administration: Oral
The purpose of the study was to investigate the cytotoxicity of Ammonium hexafluorosilicate (SiF) on human gingival fibroblasts (hGFs) under different dosages (0.001%, 0.01%, 0.1%, and 1%) and treatment durations (1, 5, 10, and 30 min). MTT assay showed that there was significantly lower number of viable cells when the hGFs were treated with 0.01% (10min), 0.1% (10 and 30 min) and 1% (5, 10, and 30min) SiF than the control group (p<0.05). MMP decreased and GSH depletion increased dramatically along with higher concentrations (0.1% and 1% SiF) and prolonged times (10 and 30 min). DNA synthesis [S (%)] of cells treated with 0.1% and 1% SiF (5, 10, and 30min) was significantly lower than the control group (p<0.05). So exposure to up to 0.01% SiF for less than 5min causes low or no cytotoxicity in vitro.
Substance Class Chemical
Created
by admin
on Sat Dec 16 03:22:21 GMT 2023
Edited
by admin
on Sat Dec 16 03:22:21 GMT 2023
Record UNII
53V4OQG6U1
Record Status Validated (UNII)
Record Version
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Name Type Language
FLUOSILICIC ACID
MI  
Common Name English
FLUOROSILIC ACID
Common Name English
DIHYDROGEN HEXAFLUOROSILICATE(2-)
Common Name English
FLUOROSILICATE
Common Name English
DIHYDROGEN HEXAFLUOROSILICATE
Common Name English
SILICON HEXAFLUORIDE DIHYDRIDE
Systematic Name English
HEXAFLUOROSILICATE(2-)HYDROGEN (1:2)
Common Name English
HEXAFLUOROSILICATE
Common Name English
HEXAFLUOROSILICIC ACID
Common Name English
FLUOROSILICIC ACID (H2SIF6)
Common Name English
FLUOSILICIC ACID [MI]
Common Name English
FLUOROSILICIC ACID
Systematic Name English
HYDROFLUOSILICIC ACID
Common Name English
NSC-16894
Code English
HYDROGEN HEXAFLUOROSILICATE (H2SIF6)
Common Name English
HYDROFLUOROSILICIC ACID
Common Name English
FLUOSILICIC ACID (HYDROFLUOSILICIC ACID)
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 75305
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
Code System Code Type Description
CHEBI
37189
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
PRIMARY
NSC
16894
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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PUBCHEM
21863527
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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ECHA (EC/EINECS)
241-034-8
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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HSDB
2018
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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EPA CompTox
DTXSID2029741
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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CAS
16961-83-4
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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SMS_ID
300000013921
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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RXCUI
1431152
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
PRIMARY
MERCK INDEX
m5484
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
PRIMARY Merck Index
FDA UNII
53V4OQG6U1
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
PRIMARY
WIKIPEDIA
HEXAFLUOROSILICIC ACID
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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MESH
C035291
Created by admin on Sat Dec 16 03:22:21 GMT 2023 , Edited by admin on Sat Dec 16 03:22:21 GMT 2023
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