DROBULINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO.ClH
Molecular Weight	319.869
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCC(O)CC(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=YKYKDSHUKOVMBU-UHFFFAOYSA-N

InChI=1S/C19H25NO.ClH/c1-15(2)20-14-18(21)13-19(16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,15,18-21H,13-14H2,1-2H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/692260 | Hathway. D.E. (2007) Foreign Compound Metabolism in Mammals, page 237, retrieved from: https://books.google.ru/books?id=6m8oDwAAQBAJ | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 471, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Drobuline is a potent cardiac depressant (anti-arrhythmic) agent, which has been found to be effective against ventricular arrhythmias in dogs. This compound is a racemic mixture having a single center of optical activity. The two isomers of drobuline were found to be equally potent in converting cardiac arrhythmias in dogs after intravenous administration. The major route of biotransformation of drobuline in the dog was shown to be conjugation with glucuronic acid.

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg/kg

Route of Administration: Oral

Name

Type

Language

DROBULINE HYDROCHLORIDE

Common Name

English

NSC-301202

Code

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-.GAMMA.-PHENYL-, HYDROCHLORIDE, (±)-

Systematic Name

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-.GAMMA.-PHENYL-, HYDROCHLORIDE

Systematic Name

English

(±)-1-(ISOPROPYLAMINO)-4,4-DIPHENYL-2-BUTANOL HYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793