PIRDONIUM BROMIDE

Details

Stereochemistry	MIXED
Molecular Formula	C22H30NO.Br
Molecular Weight	404.384
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CC1=CC=C(C=C1)C(OCC2CCCC[N+]2(C)C)C3=CC=CC=C3

InChI

InChIKey=DJJOASJXEODSJF-UHFFFAOYSA-M

InChI=1S/C22H30NO.BrH/c1-18-12-14-20(15-13-18)22(19-9-5-4-6-10-19)24-17-21-11-7-8-16-23(21,2)3;/h4-6,9-10,12-15,21-22H,7-8,11,16-17H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9832164 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 993, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/20236220

Pirdonium is an antihistamine agent. It is the hydrophilic Histamine H1 receptor antagonist.

Approval Year

PubMed

Title	Date	PubMed
Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells.	2018-01	29063596
Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.	2010-05	20236220
Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells.	2005-10	16086035
Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells.	1998-12	9832164
Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation.	1995-11	8590995

Name

Type

Language

pirdonium bromide [INN]

Preferred Name

English

PIRDONIUM BROMIDE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578