PIRDONIUM BROMIDE

Details

Stereochemistry	MIXED
Molecular Formula	C22H30NO.Br
Molecular Weight	404.384
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CC1=CC=C(C=C1)C(OCC2CCCC[N+]2(C)C)C3=CC=CC=C3

InChI

InChIKey=DJJOASJXEODSJF-UHFFFAOYSA-M

InChI=1S/C22H30NO.BrH/c1-18-12-14-20(15-13-18)22(19-9-5-4-6-10-19)24-17-21-11-7-8-16-23(21,2)3;/h4-6,9-10,12-15,21-22H,7-8,11,16-17H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C22H30NO
Molecular Weight	324.4797
Charge	1
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9832164 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 993, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/20236220

Pirdonium is an antihistamine agent. It is the hydrophilic Histamine H1 receptor antagonist.

Approval Year

PubMed

Title	Date	PubMed
Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation.	1995 Nov	8590995
Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells.	1998 Dec	9832164
Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells.	2005 Oct	16086035
Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells.	2010 May	20236220
Ca(2+) -dependent down-regulation of human histamine H(1) receptors in Chinese hamster ovary cells.	2018 Jan	29063596

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:35:42 GMT 2023` Edited by `admin` on `Sat Dec 16 16:35:42 GMT 2023`
Record UNII	5123Q291S5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIRDONIUM BROMIDE

Official Name

English

pirdonium bromide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578