U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H8N2O2
Molecular Weight 248.2362
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRYPTANTHRINE

SMILES

O=C1C2=NC3=C(C=CC=C3)C(=O)N2C4=C1C=CC=C4

InChI

InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N
InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

HIDE SMILES / InChI

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Prostaglandin G/H synthase 2
48
Target ID: P35354
Gene ID: 5743.0
Gene Symbol: PTGS2
Target Organism: Homo sapiens (Human)
Inhibitor
8297
Enoyl-[acyl-carrier-protein] reductase [NADH]
1
Target ID: P9WGR1
Gene ID: 886523.0
Gene Symbol: inhA
Target Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Inhibitor
8297
PubMed

PubMed

TitleDatePubMed
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.
2002 Oct
Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding.
2019
Name Type Language
TRYPTANTHRINE
Common Name English
TRYPTANTHRIN
Common Name English
INDOLO(2,1-B)QUINAZOLINE-6,12-DIONE
Common Name English
NSC-349447
Code English
TRIPTANTRIN
Common Name English
COUROUPITINE A
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID90157431
Created by admin on Sat Dec 16 12:51:53 GMT 2023 , Edited by admin on Sat Dec 16 12:51:53 GMT 2023
PRIMARY
PUBCHEM
73549
Created by admin on Sat Dec 16 12:51:53 GMT 2023 , Edited by admin on Sat Dec 16 12:51:53 GMT 2023
PRIMARY
NSC
349447
Created by admin on Sat Dec 16 12:51:53 GMT 2023 , Edited by admin on Sat Dec 16 12:51:53 GMT 2023
PRIMARY
FDA UNII
4Y6E3F2U66
Created by admin on Sat Dec 16 12:51:53 GMT 2023 , Edited by admin on Sat Dec 16 12:51:53 GMT 2023
PRIMARY
CAS
13220-57-0
Created by admin on Sat Dec 16 12:51:53 GMT 2023 , Edited by admin on Sat Dec 16 12:51:53 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of TRYPTANTHRINE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966