TRYPTANTHRINE

O=C1C2=NC3=C(C=CC=C3)C(=O)N2C4=C1C=CC=C4

InChIKey=VQQVWGVXDIPORV-UHFFFAOYSA-N

InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 48 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/12391548	Inhibitor 8297
Enoyl-[acyl-carrier-protein] reductase [NADH] 1 Target ID: P9WGR1 Gene ID: 886523.0 Gene Symbol: inhA Target Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Sources: https://www.ncbi.nlm.nih.gov/pubmed/30834838	Inhibitor 8297

PubMed

Title	Date	PubMed
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis.	2002 Oct	12391548
Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding.	2019	30834838

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:51:53 GMT 2023` Edited by `admin` on `Sat Dec 16 12:51:53 GMT 2023`
Record UNII	4Y6E3F2U66
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

TRYPTANTHRINE

Common Name

English

TRYPTANTHRIN

Common Name

English

INDOLO(2,1-B)QUINAZOLINE-6,12-DIONE

Common Name

English

NSC-349447

Code

English

TRIPTANTRIN

Common Name

English

COUROUPITINE A

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID90157431