TIRON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H4O8S2.2Na
Molecular Weight	314.201
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].OC1=C(O)C(=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O

InChI

InChIKey=ISWQCIVKKSOKNN-UHFFFAOYSA-L

InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells.	2001 Jan 19	11163763
Oxidative stress involves in astrocytic alterations induced by manganese.	2002 May	12009774
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.	2003 Dec 1	14678967
HSP25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase.	2004 Feb 15	14975446
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.	2004 Nov	15509775
Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress.	2005 Feb	15677497
Participation of superoxide in neutrophil activation and cytokine production.	2006 Aug	16919916
Prolonged oxidative stress inverts the cardiac force-frequency relation: role of altered calcium handling and myofilament calcium responsiveness.	2006 Jan	16288776
NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression.	2006 Sep-Oct	16987005
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.	2007 Dec 1	18032788
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts.	2007 Sep 1	17391658
Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages.	2009 Apr 15	19371603
N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells.	2009 Aug 15	19481559
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.	2009 Mar 13	19168439
Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.	2009 Nov 10	19647729
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.	2010 Jul 15	20106845
Cellular iron depletion weakens induction of heme oxygenase-1 by cadmium.	2011 Jan	20934533
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.	2012 Jul 20	22648416
NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes.	2012 Jun	22532027
Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways.	2012 Jun	22488045
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.	2012 Nov 15	22872702
Upregulation of haeme oxygenase-1 by zinc in HCT-116 cells.	2012 Sep	22564156
A synergistic vascular effect of airborne particulate matter and nickel in a mouse model.	2013 Sep	23788629
Effect of resveratrol and tiron on the inactivation of glyceraldehyde-3- phosphate dehydrogenase induced by superoxide anion radical.	2014	24059224
Arsenic trioxide induces unfolded protein response in vascular endothelial cells.	2014 Feb	23892647
Ketoconazole induces apoptosis in rat cardiomyocytes through reactive oxygen species-mediated parkin overexpression.	2015 Oct	25787151

Patents

Name

Type

Language

TIRON

Common Name

English

1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT

Common Name

English

SODIUM PYROCATECHOL-2,4-DISULFONATE

Systematic Name

English

DISODIUM-1,2-DIHYDROXYBENZENE-3,5-DISULFONATE

Systematic Name

English

NSC-12861

Code

English

4,5-DIHYDROXY-1,3-BENZENEDISULFONIC ACID DISODIUM SALT

Common Name

English

DISODIUM PYROCATECHOL-3,5-DISULFONATE

Systematic Name

English

TIRON [MI]

Common Name

English

SODIUM CATECHOL DISULFONATE

Systematic Name

English

Code System Code Type Description

FDA UNII

4X87R5T106