Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H4O8S2.2Na |
| Molecular Weight | 314.201 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].OC1=C(O)C(=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O
InChI
InChIKey=ISWQCIVKKSOKNN-UHFFFAOYSA-L
InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H4O8S2 |
| Molecular Weight | 268.221 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells. | 1999 May 15 |
|
| PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. | 2006 Apr 28 |
|
| Participation of superoxide in neutrophil activation and cytokine production. | 2006 Aug |
|
| Manganese modulates pro-inflammatory gene expression in activated glia. | 2006 Jul |
|
| NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression. | 2006 Sep-Oct |
|
| Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. | 2007 Dec 1 |
|
| Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway. | 2007 May 1 |
|
| NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. | 2007 Sep 1 |
|
| Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. | 2009 Apr 15 |
|
| N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. | 2009 Aug 15 |
|
| p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. | 2009 Mar 13 |
|
| Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. | 2009 Nov 10 |
|
| Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. | 2010 Apr 1 |
|
| Cellular iron depletion weakens induction of heme oxygenase-1 by cadmium. | 2011 Jan |
|
| Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis. | 2011 Jun 1 |
|
| NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes. | 2012 Jun |
|
| Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways. | 2012 Jun |
|
| Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress. | 2012 Nov |
|
| ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. | 2012 Nov 15 |
|
| A synergistic vascular effect of airborne particulate matter and nickel in a mouse model. | 2013 Sep |
|
| Effect of resveratrol and tiron on the inactivation of glyceraldehyde-3- phosphate dehydrogenase induced by superoxide anion radical. | 2014 |
|
| Arsenic trioxide induces unfolded protein response in vascular endothelial cells. | 2014 Feb |
|
| Ketoconazole induces apoptosis in rat cardiomyocytes through reactive oxygen species-mediated parkin overexpression. | 2015 Oct |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:57:06 GMT 2023
by
admin
on
Fri Dec 15 17:57:06 GMT 2023
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| Record UNII |
4X87R5T106
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| Record Status |
Validated (UNII)
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| Record Version |
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4X87R5T106
Created by
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DTXSID7043950
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205-741-5
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Tiron (chemical)
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m10891
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admin on Fri Dec 15 17:57:06 GMT 2023 , Edited by admin on Fri Dec 15 17:57:06 GMT 2023
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PRIMARY | Merck Index | ||
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149-45-1
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9001
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12861
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admin on Fri Dec 15 17:57:06 GMT 2023 , Edited by admin on Fri Dec 15 17:57:06 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |