Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H28N2O2 |
| Molecular Weight | 340.4592 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=CC2=C(C=CN=C2C=C1)[C@@H](O)[C@@H]3C[C@@H]4CC[N@]3C[C@@H]4CC
InChI
InChIKey=SUWZHLCNFQWNPE-LATRNWQMSA-N
InChI=1S/C21H28N2O2/c1-3-14-13-23-10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-4-2)12-18(17)19/h5-7,9,12,14-15,20-21,24H,3-4,8,10-11,13H2,1-2H3/t14-,15-,20-,21+/m0/s1
Ethylhydrocupreine Hydrochloride (optochin) is a reagent used in the alteration in bacterial morphology, it is now used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as viridans streptococci, which are resistant. However, a single standardized procedure does not exist. Optochin is included neither in the current EUCAST breakpoint tables nor in the CLSI performance standards for antimicrobial susceptibility testing.
Originator
Approval Year
Sample Use Guides
in mice: The ethylhydrocuprein (optochin base) was administered in the form of a 2 per cent solution in olive oil, given under the skin of the back. This treatment was given, in the first instance, immediately after the infection; if a second dose was given it was given after an interval of 24 hours
Route of Administration:
Other
In Vitro Use Guide
Curator's Comment: The action of ethylhydrocuprein hydrochloride on the pneumococci in vitro is so strongly specific that it may possibly be used as a test for a true pneumococcus. The inhibitory or killing effects of ethylhydrocuprein hydrochloride in vitro on bacteria other than pneumococci are slight or absent. The effects are greater on streptococci than on any other organisms examined, but are still much less than on the pneumococci. This action distinguishes between the streptococcus group, including Streptococcus mucosus sometimes found in normal mouths, on the one hand, and the true pneumococcus (including Pneumococcus mucosus), on the other. Quinine hydrochloride inhibits the growth of, and kills the pneumococcus in vitro; much stronger concentrations, however, are necessary than in the case of ethylhydrocuprein.
Unknown
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86455
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OPTOCHIN
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DTXSID50893924
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300000025491
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4W030VS2OG
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87880
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3740
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208-333-5
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522-60-1
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m175
Created by
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PRIMARY | Merck Index |
SALT/SOLVATE (PARENT)
SUBSTANCE RECORD
