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Details

Stereochemistry RACEMIC
Molecular Formula C16H22N2O3.ClH
Molecular Weight 326.818
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROCATEROL HYDROCHLORIDE

SMILES

Cl.CC[C@@H](NC(C)C)[C@@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2

InChI

InChIKey=AEQDBKHAAWUCMT-KKJWGQAZSA-N
InChI=1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m1./s1

HIDE SMILES / InChI

Description

Procaterol is a beta2-adrenoreceptor agonist. It is a bronchodilator that may be administered orally or by aerosol inhalation for the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema. The drug is not approved in the USA, but is available in Japan, Indonesia, and other countries worldwide.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
MEPTIN
Primary
MEPTIN
Primary
MEPTIN

PubMed

Sample Use Guides

In Vivo Use Guide
Meptin tablets: the usual adult dose is 50 µg (one tablet) once before bed or twice daily (in the morning and before bed) by the oral route. Meptin air: in general, for adults, inhale 2 puffs (20 mcg of active ingredient) at a time, and for children, inhale 1 puff (10 mcg of active ingredient) at a time. The dosage may be adjusted according to your disease, age, or symptoms. Strictly follow the instructed dosing schedule. The maximum dosage is restricted to 4 times daily (8 puffs for adults and 4 puffs for children).
Route of Administration: Other
In Vitro Use Guide
To study the beta2-blocking activity of procaterol, a guinea pig tracheal test was performed. The trachea was excised from male guinea pigs. A spiral section of the trachea was prepared and suspended in a 30-ml tissue bath. The condition of the tracheal muscle was monitored by isometric recordings using force transducers. Phentolamine was added to the bath fluid 15 min before induction of contraction with the test compound to block alpha-adrenergic receptors. ED50 for procaterol was 11 nM.