| Stereochemistry | RACEMIC |
| Molecular Formula | C16H22N2O3.ClH |
| Molecular Weight | 326.818 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC[C@@H](NC(C)C)[C@@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2
InChI
InChIKey=AEQDBKHAAWUCMT-KKJWGQAZSA-N
InChI=1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m1./s1
Procaterol is a beta2-adrenoreceptor agonist. It is a bronchodilator that may be administered orally or by aerosol inhalation for the treatment of dyspnea caused by bronchial asthma, chronic bronchitis, and pulmonary emphysema. The drug is not approved in the USA, but is available in Japan, Indonesia, and other countries worldwide.
CNS Activity
Originator
Approval Year
AUC
Doses
AEs
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
Drug as victim
PubMed
Patents
Sample Use Guides
Meptin tablets: the usual adult dose is 50 µg (one tablet) once before bed or twice daily (in the morning and before bed) by the oral route. Meptin air: in general, for adults, inhale 2 puffs (20 mcg of active ingredient) at a time, and for children, inhale 1 puff (10 mcg of active ingredient) at a time. The dosage may be adjusted according to your disease, age, or symptoms. Strictly follow the instructed dosing schedule. The maximum dosage is restricted to 4 times daily (8 puffs for adults and 4 puffs for children).
Route of Administration:
Other
To study the beta2-blocking activity of procaterol, a guinea pig tracheal test was performed. The trachea was excised from male guinea pigs. A spiral section of the trachea was prepared and suspended in a 30-ml tissue bath. The condition of the tracheal muscle was monitored by isometric recordings using force transducers. Phentolamine was added to the bath fluid 15 min before induction of contraction with the test compound to block alpha-adrenergic receptors. ED50 for procaterol was 11 nM.
ACTIVE MOIETY
SUBSTANCE RECORD
