U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C29H38N8O8
Molecular Weight 626.6608
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUAMECYCLINE

SMILES

[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(C=CC=C4O)[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN5CCN(CC5)C(=N)NC(N)=N)=C(O)[C@H]2N(C)C

InChI

InChIKey=DIRJDIBCAHCCFL-AQFAATAFSA-N
InChI=1S/C29H38N8O8/c1-28(44)13-5-4-6-16(38)17(13)21(39)18-14(28)11-15-20(35(2)3)22(40)19(24(42)29(15,45)23(18)41)25(43)33-12-36-7-9-37(10-8-36)27(32)34-26(30)31/h4-6,14-15,20,38,40-41,44-45H,7-12H2,1-3H3,(H,33,43)(H5,30,31,32,34)/t14-,15-,20-,28+,29-/m0/s1

HIDE SMILES / InChI
Guamecycline, a tetracycline derivative was studied in patients with broncho-pulmonary diseases and for the treatment of acute pneumopathies. However, information about the current use of this compound is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Preliminary report: electron microscopical appearance of human bronchial epithelium after long-term treatment with guamecycline by aerosol route.
1969
Guamecycline and the bronchopulmonary system. Measurement of antibiotic levels in bronchial secretion.
1969 Oct
[Effects of aerosol administration of guamecycline in patients with broncho-pulmonary diseases].
1971 Jan-Feb
[Inhibiting effects of guamecycline and of tetracycline hydrochloride on antibody-producing cells of the spleen and lymph nodes].
1971 Jan-Mar
Guamecycline in bronchial infections due to Diplococcus pneumoniae.
1972 Jan-Feb
[Guamecycline in the treatment of acute pneumopathies. Clinical research and comparison with other tetracyclines].
1972 Nov 21
Patents

Sample Use Guides

Unknown
Route of Administration: Respiratory
Name Type Language
GUAMECYCLINE
INN   MI   WHO-DD  
INN  
Official Name English
Guamecycline [WHO-DD]
Common Name English
GUAMECYCLINE [MI]
Common Name English
guamecycline [INN]
Common Name English
N-((4-(AMIDINOAMIDINO)-1-PIPERAZINYL)METHYL)-4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1595
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
Code System Code Type Description
FDA UNII
4NQR4R6G3S
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
MESH
C001312
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
EVMPD
SUB07977MIG
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
NCI_THESAURUS
C90947
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
ECHA (EC/EINECS)
240-611-1
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
MERCK INDEX
m1182
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY Merck Index
CAS
16545-11-2
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
WIKIPEDIA
Xanthomycin A
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
SMS_ID
100000084450
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
ChEMBL
CHEMBL2103960
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
DRUG CENTRAL
3273
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
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EPA CompTox
DTXSID301043159
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY
INN
2705
Created by admin on Sat Dec 16 16:21:22 GMT 2023 , Edited by admin on Sat Dec 16 16:21:22 GMT 2023
PRIMARY