AZIMEXON

Details

Stereochemistry	UNKNOWN
Molecular Formula	C9H14N4O
Molecular Weight	194.2337
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(N1CC1C#N)N2CC2C(N)=O

InChI

InChIKey=RPZOFMHRRHHDPZ-UHFFFAOYSA-N

InChI=1S/C9H14N4O/c1-9(2,12-4-6(12)3-10)13-5-7(13)8(11)14/h6-7H,4-5H2,1-2H3,(H2,11,14)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3088215 | https://www.ncbi.nlm.nih.gov/pubmed/2874196

Azimexon, a synthetic derivative of the 2-cyanaziridines, possesses the immunorestorative properties that were shown for patients with acquired immunodeficiency syndrome. Besides, azimexon had a role in managing cancer-associated dysregulation of the immune response. It was studied in clinical trials phase I to determine the drug's tolerable dose, toxicity, and effects on immune and nonimmune host defense parameters.

Approval Year

PubMed

Title	Date	PubMed
Animal experiments on the compensation of the immunosuppressive action of cyclophosphamide by 2-[-2-cyanaziridinyl-(1)-]-2-[-2-carbamoylaziridinyl-(1)]-propane BM 12 531.	1978	346364
Modulation in vitro of immune parameters in homosexual males with the preclinical complex of symptoms related to acquired immune deficiency syndrome by azimexon.	1986 Jun	3088215

Sample Use Guides

In Vivo Use Guide

Azimexon was given intravenously daily for 5 days to 19 cancer patients in a Phase I trial

Route of Administration: Intravenous

Name

Type

Language

AZIMEXON

Official Name

English

BM12,531

Code

English

azimexon [INN]

Common Name

English

BM-12,531

Code

English

BM-12531

Code

English

BM 12531

Code

English

BM 12,531

Code

English

1-((1-(2-CYANO-1-AZIRIDINYL)-1-METHYLETHYL)-2-AZIRIDINECARBOXAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C797