Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C20H27NO2.ClH |
Molecular Weight | 349.895 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC1=CC2=C(C[C@H]3N(CC4CC4)CC[C@@]25CCCC[C@@]35O)C=C1
InChI
InChIKey=QWGXEENWLDBHTR-QGPGBOAMSA-N
InChI=1S/C20H27NO2.ClH/c22-16-6-5-15-11-18-20(23)8-2-1-7-19(20,17(15)12-16)9-10-21(18)13-14-3-4-14;/h5-6,12,14,18,22-23H,1-4,7-11,13H2;1H/t18-,19+,20-;/m1./s1
Oxilorphan (also known as levo-BC-2605) was developed as a long-acting, narcotic antagonist that has agonist properties. Oxilorphan is a partial agonist at the kappa-opioid receptor and antagonist of the mu-opioid receptor. During clinical trials, oxilorphan had led to dysphoria, which combined with its hallucinogenic effects, serves to limit its clinical usefulness. As a result, many patients who experienced these side effects refused to take additional doses in clinical trials.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4472
1, 2, 4, 6, and 8 mg in 30 normal subjects to determine the relation of single oral doses and toxicity
Route of Administration:
Oral
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42281-48-1
Created by
admin on Fri Dec 15 15:35:52 GMT 2023 , Edited by admin on Fri Dec 15 15:35:52 GMT 2023
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52305-98-3
Created by
admin on Fri Dec 15 15:35:52 GMT 2023 , Edited by admin on Fri Dec 15 15:35:52 GMT 2023
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ALTERNATIVE | |||
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21159630
Created by
admin on Fri Dec 15 15:35:52 GMT 2023 , Edited by admin on Fri Dec 15 15:35:52 GMT 2023
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4IJ68MD32N
Created by
admin on Fri Dec 15 15:35:52 GMT 2023 , Edited by admin on Fri Dec 15 15:35:52 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD