Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H33N3O8.HNO3 |
| Molecular Weight | 590.5791 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[N+]([O-])=O.[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN5CCCC5)=C(O)[C@H]2N(C)C
InChI
InChIKey=BQYJYUVCGMONDI-HDJCBORZSA-N
InChI=1S/C27H33N3O8.HNO3/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30;2-1(3)4/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36);(H,2,3,4)/t14-,15-,20-,26+,27-;/m0./s1
Rolitetracycline nitrate is an antibiotic formed by N-aminomethylation of the carboxamide group of tetracycline. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. It is formulated for intravenous or intramuscular injections and is used in cases requiring high concentrations or when oral administration is impractical. In combinations with chloramphenicol and colistin, it is used as the eye drops for the treatment of external eye infections such as catarrhal conjunctivitis, purulent, trachoma, blepharitis, blepharoconjunctivitis, bacterial keratitis, septic corneal ulcers.
Approval Year
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496ESB4HTE
Created by
admin on Sat Dec 16 00:38:57 GMT 2023 , Edited by admin on Sat Dec 16 00:38:57 GMT 2023
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7681-32-5
Created by
admin on Sat Dec 16 00:38:57 GMT 2023 , Edited by admin on Sat Dec 16 00:38:57 GMT 2023
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231-664-1
Created by
admin on Sat Dec 16 00:38:57 GMT 2023 , Edited by admin on Sat Dec 16 00:38:57 GMT 2023
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54698169
Created by
admin on Sat Dec 16 00:38:57 GMT 2023 , Edited by admin on Sat Dec 16 00:38:57 GMT 2023
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PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
