ROLITETRACYCLINE NITRATE ANHYDROUS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H33N3O8.HNO3
Molecular Weight	590.5791
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ROLITETRACYCLINE NITRATE ANHYDROUS

Structure Search

SMILES

O[N+]([O-])=O.CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]2(O)C(=O)C(C(=O)NCN5CCCC5)=C1O

InChI

InChIKey=BQYJYUVCGMONDI-HDJCBORZSA-N

InChI=1S/C27H33N3O8.HNO3/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30;2-1(3)4/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36);(H,2,3,4)/t14-,15-,20-,26+,27-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	HNO3
Molecular Weight	63.0128
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C27H33N3O8
Molecular Weight	527.5662
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0015414 | https://www.ncbi.nlm.nih.gov/pubmed/1127588 | https://www.my-personaltrainer.it/Foglietti-illustrativi/Colbiocin.html

Rolitetracycline nitrate is an antibiotic formed by N-aminomethylation of the carboxamide group of tetracycline. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. It is formulated for intravenous or intramuscular injections and is used in cases requiring high concentrations or when oral administration is impractical. In combinations with chloramphenicol and colistin, it is used as the eye drops for the treatment of external eye infections such as catarrhal conjunctivitis, purulent, trachoma, blepharitis, blepharoconjunctivitis, bacterial keratitis, septic corneal ulcers.

Approval Year

PubMed

Title	Date	PubMed
Simultaneous high-speed liquid chromatographic determination of tetracycline and rolitetracycline in rolitetracycline formulations.	1975-02	1127588

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:38:33 GMT 2025` Edited by `admin` on `Mon Mar 31 20:38:33 GMT 2025`
Record UNII	496ESB4HTE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-N-(1-PYRROLIDINYLMETHYL)-, (4S-(4.ALPHA.,4A.ALPHA.,5A.ALPHA.,6.BETA.,12A.ALPHA.))-, MONONITRATE (SALT)

Preferred Name

English

ROLITETRACYCLINE NITRATE ANHYDROUS

Common Name

English

Rolitetracycline nitrate [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

496ESB4HTE