| Stereochemistry | ABSOLUTE |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.3062 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(O[C@H]2CCNC2)C3=C(CCC3)C=C1
InChI
InChIKey=QDJAYXYEXHVXJV-NSHDSACASA-N
InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1
ORG 37684 is a selective full agonist of 5-hydroxytryptamine receptor 5-HT2 family with a high selectivity for 5-HT2C in comparison with 5-HT2B and 5-HT2A receptors. It was studied for treatment of depression, but that investigations were discontinued. On animal studies ORG 37684 possessed hypophagic effect, which was exclusively mediated by activation of 5-HT2C receptors. Thus, this compound can be further investigated in using for weight loss.
Originator
Approval Year
PubMed
Sample Use Guides
To examine the effect of receptor density on agonist efficacy, three agonists of differential efficacies were examined for GTPγ35S binding; a full agonist, Org37684, a partial agonist, quipazine, and a weak partial agonist LSD. Enhancement of GTPγ35S binding by Org37684 (10 μM) ranged from 93 to 101% as normalized to that of 5-HT (10 μM), quipazine from 52 to 67%, and LSD from 23 to 29% in these cell lines, with no appreciable dependence on receptor density.
SUBSTANCE RECORD
