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Details

Stereochemistry ACHIRAL
Molecular Formula C13H12O3
Molecular Weight 216.2326
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EUPARIN

SMILES

CC(=C)C1=CC2=CC(C(C)=O)=C(O)C=C2O1

InChI

InChIKey=OPUFDNZTKHPZHM-UHFFFAOYSA-N
InChI=1S/C13H12O3/c1-7(2)12-5-9-4-10(8(3)14)11(15)6-13(9)16-12/h4-6,15H,1H2,2-3H3

HIDE SMILES / InChI

Description

Euparin is a benzofuran derivative isolated from Ligularia (Ligularia Cass) and from plant roots Eupatorium. Euparin showed low cytotoxicity on Vero cells while exerting a significant antiviral activity against the three types of polioviruses (PV-1, PV-2, and PV-3).

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Vero cell monolayers were seeded in 24-well plates. After 24 h (5% CO2 incubator, 37°C), cells were washed twice with phosphate buffer saline (PBS) and treated with 1.0 and 10 µg/mL of euparin in IM, corresponding to EC90and 10X EC90, respectively. After 7 h incubation at 37°C, the medium was removed; cell monolayers were washed three times with PBS and infected with 100 PFU/well of PV-1 in 0.1 mL of IM. Following 45 min of adsorption at 37°C, the virus inoculum was removed and PM was added. After 24 h, cells were fixed and stained and viral plaques were counted.