Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H5Cl |
Molecular Weight | 64.514 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCl
InChI
InChIKey=HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste.
Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries.
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Disc. AE: Ataxia, Dysarthria... AEs leading to discontinuation/dose reduction: Ataxia (1 patient) Sources: Dysarthria (1 patient) Hallucinations (1 patient) Hepatomegaly (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Ataxia | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Dysarthria | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Hallucinations | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Hepatomegaly | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
PubMed
Title | Date | PubMed |
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[Changes in the content of nucleic acids and total protein in exocrine pancreatocytes and the composition of their population in experimental acute pancreatitis in rats]. | 1990 |
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Sequential anaerobic-aerobic treatment of an aquifer contaminated by halogenated organics: field results. | 2002 Aug |
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Biodegradation of monohalogenated alkanes by soil NH(3)-oxidizing bacteria. | 2002 Aug |
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Volatile substance and other drug abuse inhalation in Spain. | 2003 |
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Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes. | 2003 Aug 8 |
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Local anaesthesia--before cocaine. | 2003 Feb |
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The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. | 2003 Jan 24 |
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Experimental and theoretical multiple kinetic isotope effects for an SN2 reaction. An attempt to determine transition-state structure and the ability of theoretical methods to predict experimental kinetic isotope effects. | 2003 Jun 16 |
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Studies on quinazolines. 11. Intramolecular imidate-amide rearrangement of 2-substituted 4-(omega-chloroalkoxy)quinazoline derivatives. 1,3 -O --> N shift of chloroalkyl groups via cyclic 1,3-azaoxonium intermediates. | 2003 Mar 21 |
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Synthesis and in vivo biodisposition of [14C]-quaternary ammonium-melphalan conjugate, a potential cartilage-targeted alkylating drug. | 2003 Mar-Apr |
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Fire and frost! | 2003 May |
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Reduction of halogenated ethanes by green rust. | 2004 Jan |
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Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron. | 2004 Oct |
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Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain. | 2004 Sep |
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Cytogenetic effects of 1,1-dichloroethane in mice bone marrow cells. | 2005 Apr |
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Assessment of natural or enhanced in situ bioremediation at a chlorinated solvent-contaminated aquifer in Italy: a microcosm study. | 2005 Feb |
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A target rash. | 2005 Feb 26-Mar 4 |
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Sodium channel Nav1.8 immunoreactivity in painful human dental pulp. | 2005 Jul 7 |
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Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. | 2005 Jun 2 |
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Radiolysis of aqueous solutions of 1,1- and 1,2-dichloroethane. | 2005 Nov 17 |
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Rate coefficient measurements of hydrated electrons and hydroxyl radicals with chlorinated ethanes in aqueous solutions. | 2005 Sep 1 |
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Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism. | 2006 |
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[Increased risk of malignancies in heterozygotes in families of patients with Nijmegen breakage syndrome]. | 2006 |
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Topical ethyl chloride fine spray. Does it have any antimicrobial activity? | 2006 Dec |
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De novo formation of chloroethyne in soil. | 2006 Jan 1 |
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[14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice. | 2007 Apr |
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Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines. | 2007 Dec 21 |
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DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene. | 2007 Feb |
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Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. | 2007 Feb |
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Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. | 2007 Jun |
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The Manhattan legacy. | 2007 Jun |
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Selective adsorption of volatile organic compounds in micropore aluminum methylphosphonate-alpha: a combined molecular simulation-experimental approach. | 2007 Jun 19 |
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Thermography and thermoregulation of the face. | 2007 Mar 15 |
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Signaling molecules in sulfur mustard-induced cutaneous injury. | 2007 Nov 27 |
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Treatment of myofascial trigger points in common shoulder disorders by physical therapy: a randomized controlled trial [ISRCTN75722066]. | 2007 Nov 5 |
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Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. | 2007 Oct |
|
Lignocaine is a better analgesic than either ethyl chloride or nitrous oxide for peripheral intravenous cannulation. | 2007 Oct |
|
Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution. | 2007 Oct 11 |
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Simultaneous bio-reduction of trichloroethene, trichloroethane, and chloroform using a hydrogen-based membrane biofilm reactor. | 2008 |
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Reductive dechlorination of 1, 2-dichloroethane using anaerobic sequencing batch reactor (ASBR). | 2008 |
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An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay. | 2008 Apr 30 |
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Measurement of residual solvents in a drug substance by a purge-and-trap method. | 2008 Aug 5 |
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Analgesic pretreatment for antibiotic skin test: vapocoolant spray vs ice cube. | 2008 Jan |
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Potential for identifying abiotic chloroalkane degradation mechanisms using carbon isotopic fractionation. | 2008 Jan 1 |
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Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women. | 2008 Jul |
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Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support. | 2008 May-Jun |
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Determining the transition-state structure for different SN2 reactions using experimental nucleophile carbon and secondary alpha-deuterium kinetic isotope effects and theory. | 2008 Oct 16 |
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Sir Ivan Magill KCVO, DSc, MB, BCh, BAO, FRCS, FFARCS (Hon), FFARCSI (Hon), DA, (1888-1986). | 2008 Sep |
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Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems. | 2009 Jan 1 |
|
Structural basis and specificity of human otubain 1-mediated deubiquitination. | 2009 Mar 1 |
Sample Use Guides
To apply Gebauer’s Ethyl Chloride from the amber bottle, hold the bottle inverted
while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer’s Ethyl Chloride from the
aerosol can, hold can upright over the treatment area and depress the valve
completely allowing Gebauer’s Ethyl Chloride to spray from the can.
Route of Administration:
Topical
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Classification Tree | Code System | Code | ||
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WHO-ATC |
N01BX01
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NCI_THESAURUS |
C241
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WHO-VATC |
QN01BX01
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IARC | Chloroethane |
Code System | Code | Type | Description | ||
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200-830-5
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6337
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75-00-3
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46U771ERWK
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CHEMBL46058
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CHLOROETHANE
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4141
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3196
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DB13259
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47554
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M5107
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533
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D005018
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SUB13740MIG
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C75067
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DTXSID1020302
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ACTIVE MOIETY