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Details

Stereochemistry ACHIRAL
Molecular Formula C2H5Cl
Molecular Weight 64.514
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYL CHLORIDE

SMILES

CCCl

InChI

InChIKey=HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3

HIDE SMILES / InChI

Molecular Formula C2H5Cl
Molecular Weight 64.514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste. Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries.

Approval Year

Doses

Doses

DosePopulationAdverse events​
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Ataxia, Dysarthria...
AEs leading to
discontinuation/dose reduction:
Ataxia (1 patient)
Dysarthria (1 patient)
Hallucinations (1 patient)
Hepatomegaly (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Ataxia 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Dysarthria 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Hallucinations 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Hepatomegaly 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Changes in the content of nucleic acids and total protein in exocrine pancreatocytes and the composition of their population in experimental acute pancreatitis in rats].
1990
Incidence and therapy of midazolam induced hiccups in paediatric anaesthesia.
1999
Liver damages during experimental acute pancreatitis.
2001 Jul
Quantitative structure-pharmacokinetic relationship modelling.
2001 Jul 2
Efficacy of ethyl chloride as a local anesthetic for venipuncture and intravenous cannula insertion in a pediatric emergency department.
2001 Oct
Enzyme-assisted preparation of D-tert.-leucine.
2001 Sep
Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes.
2003 Aug 8
Local anaesthesia--before cocaine.
2003 Feb
Scary white stuff.
2003 Jan
Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited.
2003 Jul
Mutagenicity and cross-linking activity of chloroalkylnitrosamines, possible new antitumor lead compounds.
2003 Jul
Fire and frost!
2003 May
Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.
2004 Oct
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain.
2004 Sep
Cytogenetic effects of 1,1-dichloroethane in mice bone marrow cells.
2005 Apr
New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica.
2005 Aug 5
Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism.
2006
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.
2006 Apr 19
Comparison of two topical treatments for dentine sensitivity.
2006 Mar
A novel proteasome inhibitor NPI-0052 as an anticancer therapy.
2006 Oct 23
[How I became the first anesthesiologist in Saint Pierre Hospital in Brussels in 1947].
2007
Concentrations of isoflurane exceeding those used clinically slightly increase the affinity of methane, but not toluene, for water.
2007 Dec
Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines.
2007 Dec 21
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome.
2007 Feb
The Manhattan legacy.
2007 Jun
Selective adsorption of volatile organic compounds in micropore aluminum methylphosphonate-alpha: a combined molecular simulation-experimental approach.
2007 Jun 19
Thermography and thermoregulation of the face.
2007 Mar 15
Occurrence and potential human-health relevance of volatile organic compounds in drinking water from domestic wells in the United States.
2007 Nov
Analgesic pretreatment for antibiotic skin test: vapocoolant spray vs ice cube.
2008 Jan
Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems.
2009 Jan 1

Sample Use Guides

To apply Gebauer’s Ethyl Chloride from the amber bottle, hold the bottle inverted while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer’s Ethyl Chloride from the aerosol can, hold can upright over the treatment area and depress the valve completely allowing Gebauer’s Ethyl Chloride to spray from the can.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:03:15 UTC 2023
Edited
by admin
on Fri Dec 15 16:03:15 UTC 2023
Record UNII
46U771ERWK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHYL CHLORIDE
HSDB   MART.   MI   USP   VANDF   WHO-DD  
Systematic Name English
GEBAUER'S ETHYL CHLORIDE
Brand Name English
ETHYL CHLORIDE [USP IMPURITY]
Common Name English
ETHANE, CHLORO-
Systematic Name English
Chloroethane
Systematic Name English
ETHYL CHLORIDE [MART.]
Common Name English
ETHYL CHLORIDE [VANDF]
Common Name English
CHLOROETHANE [IARC]
Common Name English
ETHYL CHLORIDE [MI]
Common Name English
ETHYL CHLORIDE [HSDB]
Common Name English
Ethyl chloride [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC N01BX01
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
NCI_THESAURUS C241
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
WHO-VATC QN01BX01
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
IARC Chloroethane
Code System Code Type Description
ECHA (EC/EINECS)
200-830-5
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
PUBCHEM
6337
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
CAS
75-00-3
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
FDA UNII
46U771ERWK
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
ChEMBL
CHEMBL46058
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
SMS_ID
100000078970
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
WIKIPEDIA
CHLOROETHANE
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
RXCUI
4141
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY RxNorm
DRUG CENTRAL
3196
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
DRUG BANK
DB13259
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
CHEBI
47554
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
MERCK INDEX
m5107
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY Merck Index
HSDB
533
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
MESH
D005018
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
EVMPD
SUB13740MIG
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
NCI_THESAURUS
C75067
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID1020302
Created by admin on Fri Dec 15 16:03:15 UTC 2023 , Edited by admin on Fri Dec 15 16:03:15 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY