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Details

Stereochemistry ACHIRAL
Molecular Formula C2H5Cl
Molecular Weight 64.5141
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYL CHLORIDE

SMILES

CCCl

InChI

InChIKey=HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3

HIDE SMILES / InChI

Molecular Formula C2H5Cl
Molecular Weight 64.5141
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste. Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries.

Approval Year

Doses

Doses

DosePopulationAdverse events​
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Ataxia, Dysarthria...
AEs leading to
discontinuation/dose reduction:
Ataxia (1 patient)
Dysarthria (1 patient)
Hallucinations (1 patient)
Hepatomegaly (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Ataxia 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Dysarthria 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Hallucinations 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Hepatomegaly 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
n = 1
Health Status: unknown
Age Group: 28 years
Sex: F
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Incidence and therapy of midazolam induced hiccups in paediatric anaesthesia.
1999
[Combined effects caused by chronic exposure to vinyl chloride and dichloroethane].
2001
Treatment of cervical dentin hypersensitivity with resin adhesives: 4-week evaluation.
2001 Dec
Liver damages during experimental acute pancreatitis.
2001 Jul
Quantitative structure-pharmacokinetic relationship modelling.
2001 Jul 2
Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation.
2001 Nov
Efficacy of ethyl chloride as a local anesthetic for venipuncture and intravenous cannula insertion in a pediatric emergency department.
2001 Oct
Enzyme-assisted preparation of D-tert.-leucine.
2001 Sep
Evaluating degradation rates of chlorinated organics in groundwater using analytical models.
2001 Sep
Sequential anaerobic-aerobic treatment of an aquifer contaminated by halogenated organics: field results.
2002 Aug
Biodegradation of monohalogenated alkanes by soil NH(3)-oxidizing bacteria.
2002 Aug
Pharmacological characterisation of the spared nerve injury model of neuropathic pain.
2002 Jul
Novel irreversible butyrylcholinesterase inhibitors: 2-chloro-1-(substituted-phenyl)ethylphosphonic acids.
2002 May
Experimental and theoretical multiple kinetic isotope effects for an SN2 reaction. An attempt to determine transition-state structure and the ability of theoretical methods to predict experimental kinetic isotope effects.
2003 Jun 16
[Effect of acetylsalicylic and mefenamic acids on cytoarchitectonic of skin in rats with acute local cryogenic trauma].
2003 Sep-Oct
A comparison of cold, pinprick and touch for assessing the level of spinal block at caesarean section.
2004 Jul
Alkylation damage in DNA and RNA--repair mechanisms and medical significance.
2004 Nov 2
Effect of topical vapocoolant spray on skin test wheal, flare, and pain responses.
2005 Aug
Assessment of natural or enhanced in situ bioremediation at a chlorinated solvent-contaminated aquifer in Italy: a microcosm study.
2005 Feb
A target rash.
2005 Feb 26-Mar 4
Acute inhalant-induced neurotoxicity with delayed recovery.
2005 Jan
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor.
2005 Jun 2
Utilizing a D-amino acid as a drug carrier for antineoplastic nitrogen mustard groups.
2005 May-Jun
Rate coefficient measurements of hydrated electrons and hydroxyl radicals with chlorinated ethanes in aqueous solutions.
2005 Sep 1
[Increased risk of malignancies in heterozygotes in families of patients with Nijmegen breakage syndrome].
2006
Biodegradation of vinyl chloride and cis-dichloroethene by a Ralstonia sp. strain TRW-1.
2006 Oct
Determining the partial photoionization cross-sections of ethyl radicals.
2007 Dec 13
Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines.
2007 Dec 21
Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.
2007 Jun
Ethyl chloride as a cryoanalgesic in pediatrics for venipuncture.
2007 Jun
Thermography and thermoregulation of the face.
2007 Mar 15
Occurrence and potential human-health relevance of volatile organic compounds in drinking water from domestic wells in the United States.
2007 Nov
Treatment of myofascial trigger points in common shoulder disorders by physical therapy: a randomized controlled trial [ISRCTN75722066].
2007 Nov 5
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.
2007 Oct
Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution.
2007 Oct 11
C.E.--ethyl chloride--chloroform sequence. 1907.
2007 Sep
Simultaneous bio-reduction of trichloroethene, trichloroethane, and chloroform using a hydrogen-based membrane biofilm reactor.
2008
An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
2008 Apr 30
Measurement of residual solvents in a drug substance by a purge-and-trap method.
2008 Aug 5
Analgesic pretreatment for antibiotic skin test: vapocoolant spray vs ice cube.
2008 Jan
Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women.
2008 Jul
Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support.
2008 May-Jun
Determining the transition-state structure for different SN2 reactions using experimental nucleophile carbon and secondary alpha-deuterium kinetic isotope effects and theory.
2008 Oct 16
Sir Ivan Magill KCVO, DSc, MB, BCh, BAO, FRCS, FFARCS (Hon), FFARCSI (Hon), DA, (1888-1986).
2008 Sep
Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems.
2009 Jan 1
Structural basis and specificity of human otubain 1-mediated deubiquitination.
2009 Mar 1

Sample Use Guides

To apply Gebauer’s Ethyl Chloride from the amber bottle, hold the bottle inverted while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer’s Ethyl Chloride from the aerosol can, hold can upright over the treatment area and depress the valve completely allowing Gebauer’s Ethyl Chloride to spray from the can.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Sat Jun 26 11:40:04 UTC 2021
Edited
by admin
on Sat Jun 26 11:40:04 UTC 2021
Record UNII
46U771ERWK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHYL CHLORIDE
HSDB   MART.   MI   USP   VANDF   WHO-DD  
Systematic Name English
ETHYL CHLORIDE [WHO-DD]
Common Name English
GEBAUER'S ETHYL CHLORIDE
Brand Name English
ETHANE, CHLORO-
Systematic Name English
CHLOROETHANE
Systematic Name English
ETHYL CHLORIDE [MART.]
Common Name English
ETHYL CHLORIDE [USP]
Common Name English
ETHYL CHLORIDE [VANDF]
Common Name English
CHLOROETHANE [IARC]
Common Name English
ETHYL CHLORIDE [MI]
Common Name English
ETHYL CHLORIDE [HSDB]
Common Name English
Classification Tree Code System Code
WHO-ATC N01BX01
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
NCI_THESAURUS C241
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
WHO-VATC QN01BX01
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
IARC Chloroethane
Code System Code Type Description
ECHA (EC/EINECS)
200-830-5
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
PUBCHEM
6337
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
CAS
75-00-3
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
FDA UNII
46U771ERWK
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
ChEMBL
CHEMBL46058
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
WIKIPEDIA
CHLOROETHANE
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
RXCUI
4141
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
3196
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
DRUG BANK
DB13259
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
MERCK INDEX
M5107
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY Merck Index
HSDB
533
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
MESH
D005018
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
EVMPD
SUB13740MIG
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
NCI_THESAURUS
C75067
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
EPA CompTox
75-00-3
Created by admin on Sat Jun 26 11:40:04 UTC 2021 , Edited by admin on Sat Jun 26 11:40:04 UTC 2021
PRIMARY
Related Record Type Details
ACTIVE MOIETY