Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H5Cl |
Molecular Weight | 64.514 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCl
InChI
InChIKey=HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
Molecular Formula | C2H5Cl |
Molecular Weight | 64.514 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste.
Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries.
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Disc. AE: Ataxia, Dysarthria... AEs leading to discontinuation/dose reduction: Ataxia (1 patient) Sources: Dysarthria (1 patient) Hallucinations (1 patient) Hepatomegaly (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Ataxia | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Dysarthria | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Hallucinations | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
Hepatomegaly | 1 patient Disc. AE |
300 mL 1 times / day multiple, respiratory Dose: 300 mL, 1 times / day Route: respiratory Route: multiple Dose: 300 mL, 1 times / day Sources: |
unknown, 28 years n = 1 Health Status: unknown Age Group: 28 years Sex: F Population Size: 1 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
[Changes in the content of nucleic acids and total protein in exocrine pancreatocytes and the composition of their population in experimental acute pancreatitis in rats]. | 1990 |
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Incidence and therapy of midazolam induced hiccups in paediatric anaesthesia. | 1999 |
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Liver damages during experimental acute pancreatitis. | 2001 Jul |
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Quantitative structure-pharmacokinetic relationship modelling. | 2001 Jul 2 |
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Efficacy of ethyl chloride as a local anesthetic for venipuncture and intravenous cannula insertion in a pediatric emergency department. | 2001 Oct |
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Enzyme-assisted preparation of D-tert.-leucine. | 2001 Sep |
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Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes. | 2003 Aug 8 |
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Local anaesthesia--before cocaine. | 2003 Feb |
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Scary white stuff. | 2003 Jan |
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Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited. | 2003 Jul |
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Mutagenicity and cross-linking activity of chloroalkylnitrosamines, possible new antitumor lead compounds. | 2003 Jul |
|
Fire and frost! | 2003 May |
|
Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron. | 2004 Oct |
|
Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain. | 2004 Sep |
|
Cytogenetic effects of 1,1-dichloroethane in mice bone marrow cells. | 2005 Apr |
|
New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica. | 2005 Aug 5 |
|
Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism. | 2006 |
|
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. | 2006 Apr 19 |
|
Comparison of two topical treatments for dentine sensitivity. | 2006 Mar |
|
A novel proteasome inhibitor NPI-0052 as an anticancer therapy. | 2006 Oct 23 |
|
[How I became the first anesthesiologist in Saint Pierre Hospital in Brussels in 1947]. | 2007 |
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Concentrations of isoflurane exceeding those used clinically slightly increase the affinity of methane, but not toluene, for water. | 2007 Dec |
|
Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines. | 2007 Dec 21 |
|
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. | 2007 Feb |
|
The Manhattan legacy. | 2007 Jun |
|
Selective adsorption of volatile organic compounds in micropore aluminum methylphosphonate-alpha: a combined molecular simulation-experimental approach. | 2007 Jun 19 |
|
Thermography and thermoregulation of the face. | 2007 Mar 15 |
|
Occurrence and potential human-health relevance of volatile organic compounds in drinking water from domestic wells in the United States. | 2007 Nov |
|
Analgesic pretreatment for antibiotic skin test: vapocoolant spray vs ice cube. | 2008 Jan |
|
Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems. | 2009 Jan 1 |
Sample Use Guides
To apply Gebauer’s Ethyl Chloride from the amber bottle, hold the bottle inverted
while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer’s Ethyl Chloride from the
aerosol can, hold can upright over the treatment area and depress the valve
completely allowing Gebauer’s Ethyl Chloride to spray from the can.
Route of Administration:
Topical
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:03:15 UTC 2023
by
admin
on
Fri Dec 15 16:03:15 UTC 2023
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Record UNII |
46U771ERWK
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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WHO-ATC |
N01BX01
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NCI_THESAURUS |
C241
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WHO-VATC |
QN01BX01
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IARC | Chloroethane |
Code System | Code | Type | Description | ||
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200-830-5
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6337
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75-00-3
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46U771ERWK
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CHEMBL46058
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100000078970
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CHLOROETHANE
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4141
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3196
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DB13259
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47554
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m5107
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533
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D005018
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SUB13740MIG
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C75067
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DTXSID1020302
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
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