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Details

Stereochemistry ACHIRAL
Molecular Formula C2H5Cl
Molecular Weight 64.514
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Ethyl chloride

SMILES

CCCl

InChI

InChIKey=HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3

HIDE SMILES / InChI

Molecular Formula C2H5Cl
Molecular Weight 64.514
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ethyl chloride is a colourless flammable gas at ordinary temperature and pressure. It has a characteristic ether-like odour and a burning taste. Ethyl chloride is used as a chemical intermediate, in solvents, aerosols, and anaesthesia. Currently, chloroethane is largely used as a blowing agent in foamed plastics. In the past, chloroethane was used in the production of tetraethyl lead, an anti-knock additive to leaded gasoline. Chloroethane has also been used in the production of ethyl cellulose and for miscellaneous applications including use as a solvent, for phosphorus, sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs, refrigerant, and topical anaesthetic and use in the manufacture of dyes, chemicals, and pharmaceuticals. Other uses of chloroethane are as a pulp vitality tester in dentistry, as a medication to alleviate pain associated with insect burns and stings, as an adjunct in the treatment of tinea lesions and creeping eruptions, and as a counterirritant for relief of myofacial and visceral pain syndromes. Chloroethane is also used as a solvent, as a refrigerant, and in the production of ethyl cellulose, dyes, medicinal drugs, and other commercial chemicals. It is also used to numb skin prior to medical procedures such as ear piercing and skin biopsy, and in sports injuries.

Approval Year

Doses

Doses

DosePopulationAdverse events​
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
Health Status: unknown
Age Group: 28 years
Sex: F
Sources:
Disc. AE: Ataxia, Dysarthria...
AEs leading to
discontinuation/dose reduction:
Ataxia (1 patient)
Dysarthria (1 patient)
Hallucinations (1 patient)
Hepatomegaly (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Ataxia 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
Health Status: unknown
Age Group: 28 years
Sex: F
Sources:
Dysarthria 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
Health Status: unknown
Age Group: 28 years
Sex: F
Sources:
Hallucinations 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
Health Status: unknown
Age Group: 28 years
Sex: F
Sources:
Hepatomegaly 1 patient
Disc. AE
300 mL 1 times / day multiple, respiratory
Dose: 300 mL, 1 times / day
Route: respiratory
Route: multiple
Dose: 300 mL, 1 times / day
Sources:
unknown, 28 years
Health Status: unknown
Age Group: 28 years
Sex: F
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Structural basis and specificity of human otubain 1-mediated deubiquitination.
2009-03-01
Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems.
2009-01-01
Determining the transition-state structure for different SN2 reactions using experimental nucleophile carbon and secondary alpha-deuterium kinetic isotope effects and theory.
2008-10-16
Sir Ivan Magill KCVO, DSc, MB, BCh, BAO, FRCS, FFARCS (Hon), FFARCSI (Hon), DA, (1888-1986).
2008-09
Measurement of residual solvents in a drug substance by a purge-and-trap method.
2008-08-05
Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women.
2008-07
An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
2008-04-30
Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support.
2008-04-15
Potential for identifying abiotic chloroalkane degradation mechanisms using carbon isotopic fractionation.
2008-01-01
Analgesic pretreatment for antibiotic skin test: vapocoolant spray vs ice cube.
2008-01
Simultaneous bio-reduction of trichloroethene, trichloroethane, and chloroform using a hydrogen-based membrane biofilm reactor.
2008
Reductive dechlorination of 1, 2-dichloroethane using anaerobic sequencing batch reactor (ASBR).
2008
Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines.
2007-12-21
Determining the partial photoionization cross-sections of ethyl radicals.
2007-12-13
Concentrations of isoflurane exceeding those used clinically slightly increase the affinity of methane, but not toluene, for water.
2007-12
Signaling molecules in sulfur mustard-induced cutaneous injury.
2007-11-27
Treatment of myofascial trigger points in common shoulder disorders by physical therapy: a randomized controlled trial [ISRCTN75722066].
2007-11-05
Occurrence and potential human-health relevance of volatile organic compounds in drinking water from domestic wells in the United States.
2007-11
Concurrent bioremediation of perchlorate and 1,1,1-trichloroethane in an emulsified oil barrier.
2007-10-30
Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution.
2007-10-11
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.
2007-10
Lignocaine is a better analgesic than either ethyl chloride or nitrous oxide for peripheral intravenous cannulation.
2007-10
C.E.--ethyl chloride--chloroform sequence. 1907.
2007-09
Management of pain in childhood.
2007-08
Selective adsorption of volatile organic compounds in micropore aluminum methylphosphonate-alpha: a combined molecular simulation-experimental approach.
2007-06-19
Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.
2007-06
The Manhattan legacy.
2007-06
Ethyl chloride as a cryoanalgesic in pediatrics for venipuncture.
2007-06
[14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice.
2007-04
Thermography and thermoregulation of the face.
2007-03-15
Enzymatic removal of carboxyl protecting groups. III. Fast removal of allyl and chloroethyl esters by Bacillus subtilis esterase (BS2).
2007-02-02
DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.
2007-02
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome.
2007-02
[How I became the first anesthesiologist in Saint Pierre Hospital in Brussels in 1947].
2007
Topical ethyl chloride fine spray. Does it have any antimicrobial activity?
2006-12
A novel proteasome inhibitor NPI-0052 as an anticancer therapy.
2006-10-23
Bacterial diversity of an acidic Louisiana groundwater contaminated by dense nonaqueous-phase liquid containing chloroethanes and other solvents.
2006-10
Biodegradation of vinyl chloride and cis-dichloroethene by a Ralstonia sp. strain TRW-1.
2006-10
Supercooled micro flows and application for asymmetric synthesis.
2006-09
Ethyl vinyl chloride vapocoolant spray fails to decrease pain associated with intravenous cannulation in children.
2006-09
The effect of solvent on the structure of the transition state for the S(N)2 reaction between cyanide ion and ethyl chloride in DMSO and THF probed with six different kinetic isotope effects.
2006-06-23
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.
2006-04-19
Comparison of ethyl chloride spray with topical anaesthetic in children experiencing venepuncture.
2006-04
Comparison of two topical treatments for dentine sensitivity.
2006-03
Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism.
2006
Radiolysis of aqueous solutions of 1,1- and 1,2-dichloroethane.
2005-11-17
Rate coefficient measurements of hydrated electrons and hydroxyl radicals with chlorinated ethanes in aqueous solutions.
2005-09-01
Cytogenetic effects of 1,1-dichloroethane in mice bone marrow cells.
2005-04
Modeling protic to dipolar aprotic solvent rate acceleration and leaving group effects in S(N)2 reactions: A theoretical study of the reaction of acetate ion with ethyl halides in aqueous and dimethyl sulfoxide solutions.
2005-01-27
[Changes in the content of nucleic acids and total protein in exocrine pancreatocytes and the composition of their population in experimental acute pancreatitis in rats].
1990

Sample Use Guides

To apply Gebauer’s Ethyl Chloride from the amber bottle, hold the bottle inverted while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer’s Ethyl Chloride from the aerosol can, hold can upright over the treatment area and depress the valve completely allowing Gebauer’s Ethyl Chloride to spray from the can.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:17:35 GMT 2025
Edited
by admin
on Mon Mar 31 18:17:35 GMT 2025
Record UNII
46U771ERWK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GEBAUER'S ETHYL CHLORIDE
Preferred Name English
Ethyl chloride
HSDB   MART.   MI   USP   VANDF   WHO-DD  
Systematic Name English
ETHYL CHLORIDE [USP IMPURITY]
Common Name English
ETHANE, CHLORO-
Systematic Name English
Chloroethane
Systematic Name English
ETHYL CHLORIDE [MART.]
Common Name English
ETHYL CHLORIDE [VANDF]
Common Name English
CHLOROETHANE [IARC]
Common Name English
ETHYL CHLORIDE [MI]
Common Name English
ETHYL CHLORIDE [HSDB]
Common Name English
Ethyl chloride [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC N01BX01
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
NCI_THESAURUS C241
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
WHO-VATC QN01BX01
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
IARC Chloroethane
Code System Code Type Description
ECHA (EC/EINECS)
200-830-5
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
PUBCHEM
6337
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
CAS
75-00-3
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
FDA UNII
46U771ERWK
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
ChEMBL
CHEMBL46058
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
SMS_ID
100000078970
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
WIKIPEDIA
CHLOROETHANE
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
RXCUI
4141
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY RxNorm
DRUG CENTRAL
3196
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
DRUG BANK
DB13259
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
CHEBI
47554
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
MERCK INDEX
m5107
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY Merck Index
HSDB
533
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
MESH
D005018
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
EVMPD
SUB13740MIG
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
NCI_THESAURUS
C75067
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
EPA CompTox
DTXSID1020302
Created by admin on Mon Mar 31 18:17:35 GMT 2025 , Edited by admin on Mon Mar 31 18:17:35 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> IMPURITY